About
Contact & Profiles
A5039763292
Research Areas
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Cellular Mechanics and Interactions
- Connective tissue disorders research
- Congenital heart defects research
- Phagocytosis and Immune Regulation
- Muscle Physiology and Disorders
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
Australian Regenerative Medicine Institute
2018-2023
Monash University
2018-2023
Deficiency of muscle basement membrane (MBM) component laminin-α2 leads to muscular dystrophy congenital type 1A (MDC1A), a currently untreatable myopathy. Laminin--α2 has two main binding partners within the MBM, dystroglycan and integrin. Integrins coordinate both cell adhesion signalling; however, there is little mechanistic insight into integrin's function at MBM. In order study role in development how this relates MBM's capacity handle force, an itgβ1.b−/− zebrafish line was created....
10.1093/hmg/ddy426
article
EN
Human Molecular Genetics
2018-12-19
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