A5010552254- Bat Biology and Ecology Studies
- Genetics and Physical Performance
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Physiological and biochemical adaptations
- Genetic Mapping and Diversity in Plants and Animals
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Species Distribution and Climate Change
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Diet and metabolism studies
- Animal Behavior and Reproduction
- Molecular Biology Techniques and Applications
- Exercise and Physiological Responses
- Neuroendocrine regulation and behavior
- Animal Ecology and Behavior Studies
- Circadian rhythm and melatonin
- Forensic and Genetic Research
- Genomics and Rare Diseases
- Gut microbiota and health
- Evolution and Genetic Dynamics
- High Altitude and Hypoxia
- RNA Research and Splicing
Museum of Vertebrate Zoology
2017-2024
University of California, Berkeley
2017-2024
Cornell University
2024
Utah State University
2023
Integra (United States)
2020
University of Minnesota, Duluth
2015-2017
Abstract Various animals across the tree of life express some form programmed dormancy (e.g. hibernation, diapause) to maximize fitness in highly seasonal environments. The integrated phenotype undergoing is strikingly similar among diverse groups; however, research on has historically been phylogenetically siloed. A broad comparative approach could clarify new angles for answering fundamental questions about evolution. To advance this approach, we present a cross‐taxonomic framework...
Changes in cis -regulatory regions are thought to play a major role the genetic basis of adaptation. However, few studies have linked variation with adaptation natural populations. Here, using combination exome and RNA-seq data, we performed expression quantitative trait locus (eQTL) mapping allele-specific analyses study architecture regulatory wild house mice ( Mus musculus domesticus ) individuals from five populations collected along latitudinal cline eastern North America. Mice this...
AbstractDistinguishing between genetic, environmental, and genotype × environment effects is central to understanding geographic variation in phenotypic clines. Two of the best-documented clines are Bergmann's rule Allen's rule, which describe larger body sizes shortened extremities colder climates, respectively. Although numerous studies have found inter- intraspecific evidence for both ecogeographic patterns, we still a poor extent these patterns driven by genetics, environment, or both....
Changes in gene expression are thought to play a major role adaptive evolution. While it is known that highly sensitive the environment, very few studies have determined influence of genetic and environmental effects on differences natural populations. Here, we utilize allele-specific characterize cis trans regulatory divergence temperate tropical house mice two metabolic tissues under thermal conditions. First, show pervasive between populations across conditions, with roughly 5 10% genes...
Changes in gene regulation have long been appreciated as a driving force of adaptive evolution, however the relative contributions cis- and trans- acting changes to over short evolutionary timescales remain unclear. Instances recent, parallel phenotypic evolution provide an opportunity assess whether patterns are seen at level expression, contribution cis - trans early stages divergence. Here, we studied expression liver brown adipose tissue two wild-derived strains house mice that...
The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations over a century. However, mice capture only subset of genetic variation found in wild populations, ultimately limiting potential classical inbred strains to uncover phenotype-associated variants pathways. Wild populations are reservoirs diversity that could facilitate discovery new functional disease-associated alleles, but scarcity commercially available, well-characterized limits...
Natural selection acts on phenotypic variation, which is influenced by genetic and environmental factors including the microbiome. Whether microbiome-mediated host phenotypes can be selected transmitted remains untested in vertebrates. Here, we first identified locomotor activity as a trait transmissible through gut microbiome mice. We then performed experiment, where serially transferred microbiomes from low-activity mice to independently bred germ-free Over four transfer rounds,...
Brown adipose tissue (BAT) is a thermogenic organ that vital for hibernation in mammals. Throughout the season, BAT mitochondrial uncoupling protein 1 (UCP1) enables rapid rewarming from hypothermic torpor to periodic interbout arousals (IBAs), as energy dissipated heat. However, BAT's unique ability rewarm body via nonshivering thermogenesis not necessary outside suggesting potential seasonal change regulation of function. Here, we examined proteome and bioenergetics thirteen-lined ground...
The brain of mammalian hibernators is naturally protected. Hibernating ground squirrels undergo rapid and extreme changes in body temperature perfusion as they cycle between lengthy torpor bouts brief periods euthermia called interbout arousals (IBAs). Arousal from to IBA occurs rapidly, but there no evidence injury accompanying this physiological transition. Production the hormone melatonin accompanies arousal, suggesting that it plays a protective role at time. Here, we investigated...
During hibernation, thirteen-lined ground squirrels (Ictidomys tridecemlineatus) regularly cycle between bouts of torpor and interbout arousal (IBA). Most the brain is electrically quiescent during but regains activity quickly upon to IBA, resulting in extreme oscillations energy demand hibernation. We predicted increased functional capacity mitochondria hibernation compared with spring accommodate variable demands To address this hypothesis, we examined mitochondrial bioenergetics squirrel...
Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting wide range of susceptibility. This heterogeneity not captured by standard laboratory mouse lines. We used new collection 19 wild-derived inbred lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis ( Mtb ) infection. Wild derived mice have immune responses infection that result differential ability control at early timepoints. Correlation analysis multiple...
Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting wide range of susceptibility. This heterogeneity not captured by standard laboratory mouse lines. We used new collection 19 wild-derived inbred lines collected from diverse geographic sites to identify novel phenotypes during
Abstract Understanding the genetic basis of environmental adaptation in natural populations is a central goal evolutionary biology. The conditions at high elevation, particularly low oxygen available ambient air, impose significant and chronic challenge to metabolically active animals with lowland ancestry. To understand process these novel assess repeatability evolution over short timescales, we examined signature selection from complete exome sequences house mice (Mus musculus domesticus)...
ABSTRACT The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations a century. However, mice capture narrow subset of genetic variation found in wild populations. This consideration inherently restricts scope potential discovery models narrows pool potentially identified phenotype-associated variants pathways. Wild populations are reservoirs predicted functional disease-associated alleles, but sparsity commercially available,...
Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting wide range of susceptibility. This heterogeneity not captured by standard laboratory mouse lines. We used new collection 19 wild-derived inbred lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis ( Mtb ) infection. Wild derived mice have immune responses infection that result differential ability control at early timepoints. Correlation analysis multiple...
Abstract Changes in gene regulation have long been appreciated as a driving force of adaptive evolution, however the relative contributions cis- and trans- acting changes to over short evolutionary timescales remain unclear. Instances recent, parallel phenotypic evolution provide an opportunity assess whether patterns are seen at level expression, contribution cis – trans -changes early stages divergence. Here, we studied expression liver brown adipose tissue two wild-derived strains house...
Abstract Distinguishing between genetic, environmental, and genotype-by-environment effects is central to understanding geographic variation in phenotypic clines. Two of the best-documented clines are Bergmann’s rule Allen’s rule, which describe larger body sizes shortened extremities colder climates, respectively. Although numerous studies have found inter- intraspecific evidence for both ecogeographic patterns, we still a poor extent these patterns driven by genetics, environment, or both....
Changes in gene expression are proposed to play a major role adaptive evolution. While it is known that highly sensitive the environment, very few studies have determined influence of genetic and environmental effects on regulation natural populations. Here, we utilize allele-specific characterize cis trans regulatory divergence temperate tropical house mice two metabolic tissues under thermal conditions. First, show pervasive between populations across conditions, with roughly 5-10% genes...
During the hibernation season, thirteen‐lined ground squirrels ( Ictidomys tridecemlineatus ) regularly cycle between bouts of torpor and interbout arousal (IBA). This presents a unique seasonal change in energy requirements brain. Most brain is electrically quiescent during torpor, but regains activity upon to IBA, resulting extreme oscillations demand season. We predicted that mitochondria undergo function accommodate variable demands hibernation. To address this hypothesis, we examined...