A5022917530- Livestock and Poultry Management
- Animal Nutrition and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Bat Biology and Ecology Studies
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Silkworms and Sericulture Research
- Chromosomal and Genetic Variations
- Evolution and Paleontology Studies
- Animal Ecology and Behavior Studies
- Cancer-related molecular mechanisms research
- Genetics and Physical Performance
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Livestock Farming and Management
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- DNA Repair Mechanisms
- Aquaculture Nutrition and Growth
- Effects of Environmental Stressors on Livestock
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Milk Quality and Mastitis in Dairy Cows
- Animal Virus Infections Studies
- Wildlife Ecology and Conservation
University of Nottingham
2015-2024
Jackson Laboratory
2019-2024
Florida Museum of Natural History
2022
Laboratoire de Chimie
2022
Tufts University
2022
Universities UK
2016
Federal University of Agriculture
2013
Abstract Background Hybridisation and introgression play key roles in the evolutionary history of animal species. They are commonly observed within several orders wild birds. The domestic chicken Gallus gallus domesticus is most common livestock More than 65 billion chickens raised annually to produce meat 80 million metric tons egg for global human consumption by commercial sector. Unravelling origin its genetic diversity has major application sustainable breeding improvement programmes....
Editorial on the Research Topic Food safety in low-and middle-income countriesThis is first special edition food informal markets low-and-middle income countries (LMICs).Despite their important public health and socio-economic impacts, foodborne diseases have only recently gained attention of development institutes initiatives (Grace, 2023).The result growing appreciation enormous burden disease LMICs: comparable to that malaria, HIV/AIDs or tuberculosis economic cost more than 100 billion...
The red junglefowl Gallus gallus is the main progenitor of domestic chicken, commonest livestock species, outnumbering humans by an approximate ratio six to one. genetic control for production traits have been well studied in commercial but selection pressures underlying unique adaptation and local environments remain largely unknown indigenous village chicken. Likewise, genome regions under positive wild untapped. Here, using pool heterozygosity approach, we analysed chicken populations...
The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations over a century. However, mice capture only subset of genetic variation found in wild populations, ultimately limiting potential classical inbred strains to uncover phenotype-associated variants pathways. Wild populations are reservoirs diversity that could facilitate discovery new functional disease-associated alleles, but scarcity commercially available, well-characterized limits...
As the world population grows, muscle atrophy leading to wasting could become a bigger risk. Long noncoding RNAs (lncRNAs) are known play important roles in growth and atrophy. Meanwhile, it has recently come light that many putative small open reading frames (sORFs) hidden lncRNAs; however, their translational capabilities functions remain unclear. In this study, we uncovered 104 myogenic-associated lncRNAs translated, at least peptide, by integrated transcriptome proteomic analyses....
Abstract Skeletal muscle is the largest metabolic organ in body, and its flexibility essential for maintaining systemic energy homeostasis. Metabolic inflexibility muscles a dominant cause of various disorders, impeding development. In our previous study, we found lncRNA ZFP36L2-AS (for “ ZFP36L2 -antisense transcript”) specifically enriched skeletal muscle. Here, report that upregulated during myogenic differentiation, highly expressed breast leg vitro, inhibits myoblast proliferation but...
Abstract Background Mammalian centromeres are satellite-rich chromatin domains that execute conserved roles in kinetochore assembly and chromosome segregation. Centromere satellites evolve rapidly between species, but little is known about population-level diversity across these loci. Results We developed a k -mer based method to quantify centromere copy number sequence variation from whole genome sequencing data. applied this diverse inbred wild house mouse ( Mus musculus ) genomes profile...
Abstract Background Through human-aided dispersal over the last ~ 10,000 years, house mice ( Mus musculus ) have recently colonized diverse habitats across globe, promoting emergence of new traits that confer adaptive advantages in distinct environments. Despite their status as premier mammalian model system, impact this demographic and selective history on global patterning disease-relevant trait variation wild mouse populations is poorly understood. Results Here, we leveraged 154...
Sex-specific modulation of a meiotic DNA damage checkpoint limits the requirement for PRDM9 in mammalian fertility.
In this study we assess the maternal genetic diversity and origin of indigenous village chickens from Chad complementing previous phenotypic biometric measurements studies. We analysed a 387 bp fragment mitochondrial DNA (mtDNA) D-loop region 181 three populations western (Lake Chad/Hadjer Lamis), central (Guera) south-west (Pala) at different poultry markets in N'Djamena. Twenty-five polymorphic sites 20 haplotypes are identified. Phylogenetic network analyses group all chicken into single...
In Pakistan, the origin of indigenous cockfighting chicken (ICC) or gamecock population is unknown. However, it speculated that this might have been associated with domestication, an event linked to recreational, entertainment (cockfighting), religious ornamental activities. This study aims understand and genetic diversity ICC in Pakistan. A total 185 10 captive Indian red junglefowl (
EAV-HP is an ancient retrovirus pre-dating Gallus speciation, which continues to circulate in modern chicken populations, and led the emergence of avian leukosis virus subgroup J causing significant economic losses poultry industry. We mapped integration sites Ethiopian village chickens, a Silkie, Taiwan Country chicken, red junglefowl gallus several inbred experimental lines using whole-genome sequence data. An average 75.22 ± 9.52 per bird were identified, collectively group into 279...
With 178 West African Dwarf sheep aged 1 to 3 years, a study was conducted investigate the effects of coat colour genes on body measurements, heat tolerance traits and haematological parameters. Body measurements considered included length, hair ear hip width, tail height at withers, rump height, fore cannon bone chest depth, heart girth weight. Heat were skin temperature, rectal pulse rate respiratory rate. Blood samples collected for evaluation white blood cell (WBC), red (RBC),...
Abstract Hybridization and/or introgression play a key role in the evolutionary history of animal species. It is commonly observed several orders wild birds. The domestic chicken Gallus gallus domesticus commonest livestock species exploited for benefit mankind. origin its diversity remains unsettled. Here, we report genome-wide analyses signatures within village chicken. We first established phylogeny and divergence time across genus , showing sister relationships between Grey junglefowl G....
Abstract The house mouse species complex ( Mus musculus ) is comprised of three primary subspecies. A large number secondary subspecies have also been suggested on the basis divergent morphology and molecular variation at limited numbers markers. While phylogenetic relationships among M. are well-defined, between remain less clear. Here, we integrate de novo genome sequencing museum-stored specimens mice from one m. bactrianus publicly available sequences previously characterized as...
Prior studies on transcriptomes of hypothalamus and ovary revealed that AKT3 is one the candidate genes might affect egg production in White Muscovy ducks. The role uterus during reproductive processes cannot be overemphasized. However, functional this gene tissues traits ducks remains unknown. To identify relationship between ducks, relative expression profile was first examined prior to identifying variants within may underscore [age at (AFE), number eggs 300 d (N300D), 59 wk (N59W)] 549...
Identifying genomic regions under selection is crucial for comprehending the evolutionary history of domestic chicken. The Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock production purposes. These birds show high resilience to extreme temperatures (hot and cold), typical desert environment. pressures responsible unique local adaptations in these remain largely unidentified. Here, we aimed investigate genome diversity structure...
Abstract Background Through human-aided dispersal, house mice have recently colonized new and diverse habitats across the globe, promoting emergence of traits that confer adaptive advantages in distinct environments. Despite their status as premiere mammalian model system, impact this demographic selective history on global patterning disease-relevant trait variation wild mouse populations is poorly understood. Results Here, we leveraged 154 whole-genome sequences from populations,...
The evolutionary history of domestic chicken has been subjected to debate since Charles Darwin first proposed the red junglefowl Gallus gallus spp as its sole ancestor. However, molecular evidence introgression from gray G. sonneratii in form yellow skin locus (Eriksson et al., 2008) and success producing fertile offspring hybrids (Danforth,1958; Morejohn, 1968) challenged single species origin for chicken. In this project, we analyzed full genomes 50 birds, including: 4 species, indigenous...