A5005616480- Chemical Synthesis and Reactions
- Nutrition and Health Studies
- Enzyme Catalysis and Immobilization
- Sulfur-Based Synthesis Techniques
- Animal Diversity and Health Studies
- Milk Quality and Mastitis in Dairy Cows
- Analytical Chemistry and Chromatography
- Food Chemistry and Fat Analysis
- Chemical Synthesis and Analysis
- Orthopedic Infections and Treatments
- Advanced Synthetic Organic Chemistry
- Virus-based gene therapy research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metabolism and Genetic Disorders
- Food Industry and Aquatic Biology
- Biochemical Acid Research Studies
- Meat and Animal Product Quality
- Antimicrobial agents and applications
- Digestive system and related health
- Veterinary Pharmacology and Anesthesia
- Synthesis and biological activity
- Ionic liquids properties and applications
- Bioactive Compounds and Antitumor Agents
- Management, Economics, and Public Policy
- Asymmetric Hydrogenation and Catalysis
University College London
2023-2025
King's College London
2020-2021
Queen Mary University of London
2020
Transnational Press London
2020
University of Milan
1993
Two new monooxygenase biocatalysts, the Baeyer-Villiger BVMO145 and flavin FMO401 from Almac library, have been found to catalyse enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild green conditions. The biocatalyst provides (
Transketolases (TKs) are thiamine diphosphate (ThDP)‐dependent enzymes that catalyze the transfer of two‐carbon units in a stereoselective manner, making them valuable biocatalysts for sustainable processes. Most known TKs about 650 amino acids long; however, second type found Archaea and many Bacteria consists two proteins, each 300 acids. Exploring unique features differences split may help assessing their potential use biocatalysis uncovering new reactivities. Additionally, it could...
Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides. This work describes identification selective and robust MsrA able to catalyze reduction a variety aromatic aliphatic chiral sulfoxides at 8-64 mM concentration with high yields excellent ees (up 99%). Moreover, aim expand substrate scope biocatalysts, library mutant has been designed via rational mutagenesis utilizing...
The enantioselective synthesis of α-thiocarboxylic acids by biocatalytic dynamic kinetic resolution (DKR) nitrile precursors exploiting nitrilase enzymes is described. A panel 35 biocatalysts were screened and Nit27 Nit34 found to catalyse the DKR racemic α-thionitriles under mild conditions, affording corresponding carboxylic with high conversions good-to-excellent ee. ammonia produced in situ during transformation favours racemization enantiomers and, turn, without need any external additive base.
Sulfoxides have been synthesised from various sulfide substrates under mild conditions exploiting CALB biocatalyst in the presence of urea hydrogen peroxide and AcOEt which acts with dual role solvent reagent.
A study to set up mathematical models which allow the prediction of Enterococcus faecium growth in bologna sausage (mortadella) was carried out. Growth curves were obtained at different temperatures (5, 6, 12, 15, 25, 32, 35, 37, 42, 46, 50, 52, and 55 degrees C). The Gompertz logistic models, modified by Zwietering, found fit with representation experimental curves. variations parameters (i.e., asymptotic value reached relative population during stationary phase), mu m maximum specific rate...
Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, current drugs are ineffective latent drug-resistant HSV infections. A series amidinourea compounds, designed analogues antiviral drug moroxydine, has been synthesized evaluated potential non-nucleoside anti-HSV agents. Three compounds showed micromolar activity HSV-1 low cytotoxicity, turning to be promising candidates for future...
A new class of amphiphilic molecules, the lipoguanidines, designed as hybrids guanidine and fatty acid compounds, has been synthesized developed. The molecules present both a polar head lipophilic tail that allow them to disrupt bacterial membranes sensitize Gram-negative bacteria action narrow-spectrum antibiotics rifampicin novobiocin. lipoguanidine 5g sensitizes Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli rifampicin, thereby reducing antibiotic...