A5030757758- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Minimally Invasive Surgical Techniques
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal and Anal Carcinomas
- Pelvic floor disorders treatments
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Evolution and Paleontology Studies
- Erythrocyte Function and Pathophysiology
- Delphi Technique in Research
- Complement system in diseases
- Diverticular Disease and Complications
- Electrolyte and hormonal disorders
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Glycosylation and Glycoproteins Research
- Surgical Sutures and Adhesives
- Abdominal Surgery and Complications
- Anatomy and Medical Technology
- Cancer Genomics and Diagnostics
Victorian Comprehensive Cancer Centre
2021-2023
Peter MacCallum Cancer Centre
2020-2023
Epworth Hospital
2020-2023
The University of Melbourne
2021-2023
National Cancer Centre Japan
2023
Cleveland Clinic
2022
Dandenong Hospital
2019
Monash Health
2019
St George's Hospital
2003
St George's, University of London
2003
Mammalian cells in culture, transfected with human renin gene, can provide a useful tool for studying biosynthesis and secretion. We fibroblast (mouse L929 Chinese hamster ovary cells) pituitary tumor AtT-20) the gene selectable plasmid (pSV2Neo). Transfected fibroblasts synthesize prorenin only. Prorenin is secreted by constitutively secretion not influenced 8-bromo-cAMP. On other hand, AtT-20 synthesized both mature active renin. release constitutive but regulated mechanism since of former...
Abstract Aim To explore the feasibility and safety of robotic beyond total mesorectal excision (TME) surgery for primary recurrent pelvic malignancy. Methods Patients undergoing TME resections or malignancy between July 2015 2021 in a public quaternary private tertiary centre were included. Demographic clinical data recorded outcomes analysed. Results Twenty‐four patients (50% males) included, with median age 58 (45–70.8) years, BMI 26 (24.3–28.1) kg/m 2 . Indication was rectal...
Recent surgical advances have led to the increased survival of critically ill patients requiring postoperative nutritional supplementation. One technique, which has been increasingly used, is that open peritoneal cavity. In these cases, peritoneum left open, and viscera are protected with a temporary dressing until abdomen can be closed. The aim this study was evaluate efficacy tolerance enteral nutrition in who need cavity management techniques. Patients at tertiary referral center use...
Abstract Background Despite reports of increasing adoption robotics in colorectal surgery worldwide, data regarding its uptake Australasia are lacking. This study examines the trends robotic Australia during last 10 years. Methods Data from patients undergoing with da Vinci platform between 2010 and 2019 were obtained. Overall, numbers specific procedures across obtained Medicare Benefit Schedule over same period. Pearson's correlation analysis was used to determine statistical overall time....
Abstract Background Although currently limited, the requirement for colorectal trainees to attain skills in robotic surgery is likely increase due further utilization of platforms globally. The aim study describe training programme utilized and assess outcomes fellowship surgery. Methods A structured was generated across a tertiary hospital setting. Review four prospectively maintained fellow operative logbooks performed caseload skill acquisition. Operative patient‐related were compared...
Background: Surgical site infection is a common cause of post-operative morbidity. Although number studies on negative pressure dressings including PICOTM (Smith & Nephew, St. Petersburg, PL) have shown reduced rates surgical infections (SSI), more evidence required. This study sought to determine if PICO reduce or other complications in primarily closed laparotomy incisions after clean-contaminated surgery moderate-risk patients. Methods: Patients undergoing and bowel resection were...
Although several studies compare the clinical outcomes and costs of laparoscopic robotic proctectomy, most them reflect utilisation older generation platforms. The aim this study is to financial proctectomy within a public healthcare system, utilising multi-quadrant platform.Consecutive patients undergoing between January 2017 June 2020 in quaternary centre were included. Demographic characteristics, baseline clinical, tumour operative variables, perioperative, histopathological compared...
Insulin-like growth factors (IGFs) found in plasma and other body fluids circulate association with specific binding proteins. We report here the cloning nucleotide sequence of cDNAs for growth-hormone-dependent acid-stable IGF protein, hIGF-BP3. The derived protein begins a putative 27-amino acid signal peptide followed by 264 residues mature polypeptide. predicted contains three potential N-linked glycosylation sites shares two region homology low-molecular-weight...
Summary. Antithymocyte globulin (ATG) is widely used in the treatment of aplastic anaemia (AA) and a response occurs 60–80% patients. However, its exact mechanism action AA has yet to be determined. Previously, we have shown that ATG increases colony growth from purified bone marrow CD34 + cells patients vitro , decreases stem cell apoptosis expression soluble Fas receptor after therapy vivo . The aim this study was further examine association with haemopoietic progenitor cells. We describe...
Paroxysmal nocturnal haemoglobinuria (PNH) has a dual pathogenesis. PIG-A mutations generate clones of haemopoietic stem cells (HSC) lacking glycosylphosphatidylinositol (GPI)-anchored proteins and, secondly, these expand because selective advantage related to bone marrow failure. The first aspect been elucidated in detail, but the mechanisms leading clonal expansion are not well understood. We have previously shown that apoptosis and Fas expression HSC play role failure during aplastic...
JTL received educational grant funded by Intuitive Surgical and SW Honorarium for proctoring robotic cases.
Abstract Background: The aim of this study is to explore the impact approach on conversion in patients undergoing minimally invasive restorative total mesorectal excisionwithin a single unit. Methods: A retrospective cohort was conducted at public quaternary and private tertiary centre. Patients with rectal cancer excision between January 2006 June 2020 were included. Subjects grouped according presence conversion. Baseline variables short-term outcomes compared. Regression analyses...
Abstract Aim: This study aims to compare the financial and clinical outcomes of robotic laparoscopic proctectomy within a public healthcare system. Methods: Consecutive patients undergoing between January 2017 June 2020 in quaternary centre were included. Demographic characteristics, baseline clinical, tumour operative variables, perioperative, histopathological costs compared groups. Simple linear regression generalised model analyses with gamma distribution log-link function used determine...