A5089663055- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Eosinophilic Disorders and Syndromes
- Cell Image Analysis Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Pancreatitis Pathology and Treatment
- Systemic Sclerosis and Related Diseases
- Cancer Cells and Metastasis
- Liver Diseases and Immunity
- Genetic Syndromes and Imprinting
- Lung Cancer Research Studies
- Birth, Development, and Health
- Endoplasmic Reticulum Stress and Disease
- CAR-T cell therapy research
- Connective Tissue Growth Factor Research
Amgen (United States)
2022-2025
Bristol-Myers Squibb (United States)
2020-2022
University of Southern California
2013-2020
DNA methylation is implicated in a surprising diversity of regulatory, evolutionary processes and diseases eukaryotes. The introduction whole-genome bisulfite sequencing has enabled the study at single-base resolution, revealing many new aspects highlighting usefulness methylome data understanding variety genomic phenomena. As number publicly available studies reaches into hundreds, reliable convenient tools for comparing analyzing methylomes become increasingly important. We present...
DNA methylation is of pivotal importance during development. Previous genome-wide studies identified numerous differentially methylated regions upon differentiation stem cells, many them associated with transcriptional start sites. We present the first genome-wide, single-base-resolution view into dynamics a mammalian epithelial cell: mouse small intestinal Lgr5+ cell. Very little change was observed at sites and our data suggest that differentiation-related genes are already primed for...
Nonalcoholic steatohepatitis (NASH) is a major cause of liver-related morbidity and mortality worldwide. Liver fibrosis stage, key component NASH, has been linked to the risk clinical outcomes. Currently there are no validated noninvasive diagnostics that can differentiate between stages in patients with NASH; many existing tests do not reflect underlying disease pathophysiology. Noninvasive biomarkers needed identify at high-risk NASH advanced fibrosis. This was retrospective study...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with limited treatment options. A phase 2 trial (NCT01766817) showed that twice-daily BMS-986020, lysophosphatidic acid receptor 1 (LPA ) antagonist, significantly decreased the slope of forced vital capacity (FVC) decline over 26 weeks compared placebo in patients IPF. This analysis aimed to better understand impact LPA antagonism on extracellular matrix (ECM)-neoepitope biomarkers and function through...
The placental epigenome plays a vital role in regulating mammalian growth and development. Aberrations DNA methylation are linked to several disease states, including intrauterine restriction preeclampsia. Studying the evolution development of is critical understanding origin progression such diseases. Although high-resolution studies have found substantial variation between methylomes different species, nature methylome has yet be characterized within any individual species. We conducted...
Abstract Xaluritamig, a novel STEAP1 x CD3 XmAb® 2+1 T-cell engager, is showing initial safety and efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC). Here, we report on the association of baseline tumor peripheral biomarker characteristics first-in-human dose exploration trial. We examined target expression by immunohistochemistry fresh archival biopsies, immune populations multiparameter flow cytometry, somatic mutations via circulating DNA (ctDNA) plasma....
Abstract Background Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, cultured cell lines. Existing methods for deciding whether PMDs exist sample, as well their identification, few, often tailored to questions, require high coverage samples accurate identification. Results In this study, we outline set axioms that take step towards functional definition PMDs, describe an improved method...
<h3>Background</h3> AMG 119 is a CAR-T cell therapy that targets delta-like ligand 3 (DLL3), an inhibitory Notch expressed on the surface of most SCLC cells. In preclinical studies, specifically lysed DLL3-expressing lines and inhibited tumor growth in xenograft models.<sup>1</sup> <h3>Methods</h3> Primary objectives this open-label, phase 1 study are to determine safety, tolerability, optimum dose adults with relapsed/refractory who progressed after ≥1 platinum-based chemotherapy regimen....
Increased serum bile acids (BAs) have been observed in patients with non-alcoholic steatohepatitis (NASH). Pegbelfermin (PGBF), a polyethylene glycol-modified (PEGylated) analogue of human fibroblast growth factor 21 (FGF21), significantly decreased hepatic steatosis and improved fibrosis biomarkers metabolic parameters NASH phase IIa trial. This exploratory analysis evaluated the effect PGBF on BAs explored potential underlying mechanisms.Serum 7α-hydroxy-4-cholesten-3-one (C4) were...
Abstract Objective SSc is a rheumatic autoimmune disease affecting roughly 20 000 people worldwide and characterized by excessive collagen accumulation in the skin internal organs. Despite high morbidity mortality associated with SSc, there are no approved disease-modifying agents. Our objective this study was to explore transcriptomic model-based drug discovery approaches for SSc. Methods In study, we explored molecular basis pathogenesis well-studied mouse model of scleroderma. We profiled...