A5085730979- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- European Politics and Security
- Gas Sensing Nanomaterials and Sensors
- Diabetes Treatment and Management
- European and Russian Geopolitical Military Strategies
- European Union Policy and Governance
- Cell Image Analysis Techniques
- Cellular Mechanics and Interactions
- Analytical Chemistry and Sensors
- Gene Regulatory Network Analysis
- Metabolism, Diabetes, and Cancer
- Pluripotent Stem Cells Research
- Pharmacology and Obesity Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- European and International Law Studies
- Cancer, Lipids, and Metabolism
- Plant and animal studies
- Peroxisome Proliferator-Activated Receptors
- Cancer Cells and Metastasis
- Diabetes Management and Research
- Mathematical Biology Tumor Growth
University of Würzburg
2018-2025
Philipps University of Marburg
2006-2024
Center for Systems Biology Dresden
2024
Goethe University Frankfurt
2014-2023
University Hospital Frankfurt
2023
University Hospital Carl Gustav Carus
2009-2022
TU Dresden
2008-2022
University of Regensburg
2022
DIPF | Leibniz Institute for Research and Information in Education
2021
Deutsche Nationalbibliothek
2021
Major brassinosteroid (BR) effects such as BR-induced growth are mediated through genomic pathways because RNA synthesis inhibitors and protein interfere with these processes. A limited number of BR-regulated genes have been identified hitherto. The majority (such BRU1, CycD3, Lin6, OPR3, TRIP-1) were by comparisons BR-treated versus control-treated plants. However, altered transcript levels after BR application may not reflect normal physiological events. complementary approach is the...
OBJECTIVE—Insulin resistance is an independent risk factor for arteriosclerosis and cardiovascular mortality. However, the mechanism by which insulin contributes to unknown. Conceivably, endothelial dysfunction could be involved. Therefore, we asked whether therapy ameliorates any dysfunction. RESEARCH DESIGN AND METHODS—We performed a double-blind cross-over trial of 12 patients with recently diagnosed type 2 diabetes. They received rosiglitazone 4 mg b.i.d. weeks nateglinide 60 same number...
We propose and demonstrate a hybrid cavity system in which metal nanoparticles are evanescently coupled to dielectric photonic crystal using nanoassembly method. While the constituents lead strongly localized fields, optical feedback is provided by surrounding structure. The combined effect of plasmonic field enhancement high quality factor (Q approximately 900) opens new routes for control light-matter interaction at nanoscale.
Objecative Acarbose inhibits α-glucosidases of the small intestine and thus delays glucose release from complex carbohydrates. Therefore, its efficacy acceptability as a first-line drug in non-insulin-dependent diabetes mellitus (NIDDM) insufficiently treated with diet alone was tested randomized double-blind placebo-controlled study. Research Design And Methods Ninety-four NIDDM subjects, aged 43–70 yr average body mass index 28 kg/m2 undergoing pretreatment period at least 3 mo alone, were...
Objective In a randomized 5-yr multi-intervention trial, we tested the efficacy of intensified health education (IHE) in improving metabolic control and reducing level coronary risk factors incidence ischemic heart disease (IHD). Research Design Methods Within intervention group, benefit clofibric acid was evaluated double-blind study. One thousand one hundred thirty-nine newly diagnosed middle-aged (30- to 55-yr-old) patients with non-insulindependent diabetes mellitus (NIDDM) entered They...
Spheroids resemble features of tissues and serve as model systems to study cell-cell cell-ECM interactions in non-adhesive three-dimensional environments. Although it is generally accepted that mature spheroids tissue properties very well, no studies relate different phases the spheroid formation processes contribute integrity. Tissue integrity involves cellular adhesion formation, reinforcement, rearrangement well proliferation. They maintain structure function and, upon dysregulation,...
Abstract Objective To determine the effect of joint protection and home exercises on hand function patients with osteoarthritis (OA). Methods Randomized, controlled, 3‐month trial a blinded assessor. Primary outcome parameter was grip strength; secondary parameters were Health Assessment Questionnaire visual analog scales (VAS) for pain global function. Forty OA randomly assigned to 2 groups: One group received instruction (JPE group), control an information session about OA. Results Grip...
Microalbuminuria, an early feature of diabetic nephropathy, indicates intrarenal endothelial damage. In type 2 diabetes, microalbuminuria is strongly related to insulin resistance. We therefore investigated whether rosiglitazone, insulin-sensitizing drug that known improve dysfunction, was able dysfunction and microalbuminuria. Nineteen patients participated in this double-blind cross-over trial. Nine with newly diagnosed disease without were randomized a treatment rosiglitazone or...
Within the Siemens current limiter program a 100 kVA functional model has been realized and tested successfully. According to modular concept of is assembled ten switching elements. YBCO-films with thickness 250 nm critical density above 2/spl times/10/sup 6/ A/cm/sup 2/ are deposited by thermal coevaporation (TU Munich) on 4" sapphire wafers. To support homogeneous superconducting film covered Au-shunt layer. Good limiting performance achieved: steady below nominal current, peak fault...
Background and objective The involvement of the oral microbiota as a possible link between periodontitis, type 2 diabetes mellitus obesity is still not well understood. study was to investigate if glycemic control play role in modulating composition diversity microbial ecology. Material methods A cohort patients with (n = 18) recruited. Participants demonstrating improved after 3 months 6) were included second examination. full mouth examination performed estimate periodontitis severity...
A key event in cellular physiology is the decision between membrane biogenesis and fat storage. Phosphatidic acid (PA) an important intermediate at branch point of these pathways continuously monitored by transcriptional repressor Opi1 to orchestrate lipid metabolism. In this study, we report on mechanism recognition identify amphipathic helix (AH) for selective binding PA over phosphatidylserine (PS). The insertion AH into core renders sensitive acyl chain composition provides a means...
Deregulated MYCN is a driver of aggressive pediatric and adult neuroendocrine tumors, but critical oncogenic processes downstream remain poorly defined. In neuroblastoma, interacts with activates the Aurora-A kinase. Here we show that CDK-activating kinase for CDK12 by phosphorylating T893 in T-loop, thereby enhancing its activity. Aurora-A-dependent activation controls phosphorylation T4 RNA polymerase recruits transcription termination complexes, preventing transcription-replication...
The aim of this work is to develop a function model resistive HTSC fault current limiter. switching elements the limiter are bath-cooled in liquid nitrogen cryostat. consist YBaCuO films which deposited on different substrates with critical densities up 3/spl middot/10/sup 6/ A/cm/sup 2/. For most effective limiting samples so far peak let-through was twice tile nominal and steady short-circuit below current. concept 100 kVA introduced.
Abstract Three-dimensional multicellular aggregates such as spheroids provide reliable in vitro substitutes for tissues. Quantitative characterization of at the cellular level is fundamental. We present first pipeline that provides three-dimensional, high-quality images intact resolution and a comprehensive image analysis completes traditional segmentation by algorithms from other fields. The combines light sheet-based fluorescence microscopy optically cleared with automated nuclei (F score:...
Stilbene synthase is a key enzyme for the production of phytoalexin resveratrol. Some clones Vitis sylvestris, wild European grapevine species which almost extinct, have been shown to accumulate more resveratrol in response different forms stress. In current study, we asked whether induction stilbene transcripts Hoe29, one V. sylvestris with elevated inducibility, might result from transcription factor MYB14. The MYB14 promoter Hoe29 and Ke83 (a second stilbene-inducible genotype) harboured...
Abstract Animals must slow or halt locomotion to integrate sensory inputs change direction. In Caenorhabditis elegans , the GABAergic and peptidergic neuron RIS mediates developmentally timed quiescence. Here, we show functions additionally as a stop neuron. optogenetic stimulation caused acute persistent inhibition of pharyngeal pumping, phenotypes requiring FLP-11 neuropeptides GABA. photoactivation allows animal maintain its body posture by sustaining muscle tone, yet inactivating motor...
Background: Vasculature is an essential part of all tissues and organs involved in a wide range different diseases. However, available software for blood vessel image analysis often limited: Some only process two-dimensional data, others lack batch processing, putting time burden on the user, while still require tightly defined culturing methods experimental conditions. This highlights need that has ability to three-dimensional data requires few simple preparation steps. Results: We present...
Influenza A viruses (IAV) contain eight negative-sense single-stranded viral RNA (vRNA) molecules, which are transcribed into mRNA and replicated via complementary (cRNA). These processes tightly regulated, but the precise molecular mechanisms governing switch from transcription to replication remain elusive. Here, we introduce multiple direct-RNA assisted padlock probing in combination with situ sequencing (mudRapp-seq) visualize of all IAV vRNA molecules at single-cell level. We...