A5031706417- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Oral and gingival health research
- Dental Health and Care Utilization
- Salivary Gland Disorders and Functions
- HIV/AIDS oral health manifestations
- RNA modifications and cancer
- Diabetes and associated disorders
- Dental Erosion and Treatment
- Inflammasome and immune disorders
- Osteomyelitis and Bone Disorders Research
- Periodontal Regeneration and Treatments
- Antimicrobial Peptides and Activities
- NF-κB Signaling Pathways
- Dental Implant Techniques and Outcomes
- Inflammatory mediators and NSAID effects
- Genetic Associations and Epidemiology
- Vitamin D Research Studies
- Endodontics and Root Canal Treatments
- Memory and Neural Mechanisms
- Inflammatory Bowel Disease
- Paraoxonase enzyme and polymorphisms
- Respiratory viral infections research
Technische Universität Dresden
2012-2024
University Hospital Carl Gustav Carus
2009-2020
Poliklinik für Zahnerhaltung und Parodontologie
2009-2012
Kiel University
2010
Academic Center for Dentistry Amsterdam
2010
University of Amsterdam
2010
Ludwig-Maximilians-Universität München
2010
University of Lübeck
2008
Zimmer Biomet (Germany)
2008
Universität Greifswald
2004-2008
Background: Periodontitis is a local inflammatory process mediating destruction of periodontal tissues triggered by bacterial insult. However, this disease also characterized systemic host responses that may contribute, in part, to the recently reported higher risk for cardiovascular (CVD) among patients with periodontitis. Moderate elevation C‐reactive protein (CRP) has been found be predictor increased CVD. Elevated CRP levels have several groups. In study, we examined whether plasma are...
Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and periodontitis. Both diseases are associated with similar risk factors characterized by chronic inflammatory process. In candidate-gene association study, we identify an of genetic susceptibility locus shared both diseases. We confirm the known two neighboring linkage disequilibrium regions on human chromosome 9p21.3 CHD show additional strong these loci aggressive For lead SNP main region,...
Periodontitis is a widespread, complex inflammatory disease of the mouth, which results in loss gingival tissue and alveolar bone, with aggressive periodontitis (AgP) as its most severe form. To identify genetic risk factors for periodontitis, we conducted genome-wide association study German AgP patients. We found to be strongly associated intronic SNP rs1537415, located glycosyltransferase gene GLT6D1. replicated panel Dutch generalized localized In combined analysis including 1758...
Periodontitis is one of the most common inflammatory diseases, with a prevalence 11% worldwide for severe forms and an estimated heritability 50%. The disease characterized by destruction alveolar bone due to aberrant host response dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted GWAS using German Dutch case-control sample aggressive periodontitis (AgP, 896 cases, 7,104 controls), rare but...
Background: Previous studies have suggested that periodontal disease may be an important risk factor for preterm low birth weight. However, the link between health status of pregnant women and weight is contentious, as recent found no association periodontitis pregnancy outcome. Objective: The aim this study was to investigate potential in a German Caucasian population. Methods: Fifty‐nine with high infant (suffering from contractions, cases, group 1) well 42 control contractions during...
Abstract Aim Many studies investigated the role of genetic variants in periodontitis, but few were established as risk factors. We aimed to validate associations recent candidate genes aggressive periodontitis (AgP). Material and Methods analysed 23 600 German AgP patients 1441 controls on Illumina custom genotyping array Immunochip. tested a suggestive association Dutch German/Austrian case‐control sample, chronic (CP) sample using Sequenom iPlex assays. additionally common known variant...
Background— Genetic studies demonstrated the presence of risk alleles in genes ANRIL and CAMTA1/VAMP3 that are shared between coronary artery disease (CAD) periodontitis. We aimed to identify further genetic factors better understand conjoint mechanisms. Methods Results— In-depth genotyping 46 published CAD loci genome-wide significance worldwide largest case–control sample severe early-onset phenotype aggressive periodontitis (AgP) with Illumina Immunochip (600 German AgP cases, 1448...
Background and objective The involvement of the oral microbiota as a possible link between periodontitis, type 2 diabetes mellitus obesity is still not well understood. study was to investigate if glycemic control play role in modulating composition diversity microbial ecology. Material methods A cohort patients with (n = 18) recruited. Participants demonstrating improved after 3 months 6) were included second examination. full mouth examination performed estimate periodontitis severity...
During the last few years, risk assessment has become one of main topics periodontal research. Therefore, aim this study was to determine whether a predisposition metabolic disorders such as diabetes mellitus (in absence diagnosed diabetic disease) or hyperlipidemia may be indicators for periodontitis.One hundred patients ranging in age from 40 70 years were examined. The classified having impaired glucose tolerance (IGT) but no manifest (56 patients), (17 patients, HL), normal status (27...
Epidemiological studies have indicated a relationship between coronary heart disease (CHD) and periodontitis. Recently, <i>CDKN2BAS</i> was reported as shared genetic risk factor of CHD aggressive periodontitis (AgP), but the causative variant has remained unknown. To identify validate variants in different European populations, we first explored 150 kb region including adjacent genes <i>CDKN2A</i> <i>CDKN2B</i>, covering 51 tagging single nucleotide polymorphisms (tagSNPs) AgP chronic (CP)...
Severe periodontitis affects about 10% of the world population. In addition, associations between and systemic diseases exist. Therefore, diagnosis should be made quickly at an early stage. Matrix metalloproteinase-8 (MMP-8) is most prominent collagenase found in inflamed periodontal tissues. Its active form (aMMP-8) increasingly used as a diagnostic biomarker. Aim present study to evaluate accuracy novel aMMP-8 point-of-care (POC) test comparison standard laboratory diagnose disease rapidly...
The human chromosomal region 9p21.3 has been shown to be strongly associated with Coronary Heart Disease (CHD) in several Genome-wide Association Studies (GWAS). Recently, this also Aggressive Periodontitis (AgP), strengthening the hypothesis that established epidemiological association between periodontitis and CHD is caused by a shared genetic background, addition common environmental behavioural risk factors. However, size of analyzed cohorts primary analysis was small compared other...
Abstract Aim Periodontitis ( PD ) is influenced by genetic as well lifestyle and socio‐economic factors. Epidemiological studies show that men are at greater risk of severe forms , suggesting interplay between sex We aimed to systematically analyse patients with aggressive periodontitis (AgP) for gene–sex interactions. Materials Methods Three hundred twenty‐nine German AgP cases 983 controls were genotyped Affymetrix 500K Arrays analysed logistic regression analysis. The most significant...
Background and Objective Matrix metalloproteinase‐8 ( MMP ‐8) is involved in a wide range of pathologies including periodontitis cardiovascular diseases CVD ). The association between has been repeatedly recognized. aim the study was to analyze what extent circulating active ‐8 aMMP associated with periodontal disease status oral fluid levels otherwise healthy subjects. Material Methods In cross‐sectional study, measured serum 59 volunteers, comprising 19 periodontally subjects, 20 patients...
Introduction . Periodontitis is an inflammatory process in response to dental biofilm and leads periodontal tissue destruction. The aim of this study was the comparison outcomes using either enamel matrix derivative (EMD) or a nanocrystalline hydroxyapatite (NHA) regenerative therapy after 6 12 months. Methods Using parallel group, prospective randomized design, we enrolled 19 patients each group. primary outcome bone fill Attachment gain, probing pocket depth (PPD) reduction, recession were...
COX-2 plays an important role in periodontitis by mediating inflammatory reactions periodontal tissues, and the polymorphisms rs20417 rs689466 have been reported to be associated with populations of Taiwanese Chinese ethnicity. To test whether these variants were European ethnicity, we genotyped single-nucleotide (SNPs) rs6681231, latter a haplotype tagging SNP (htSNP) for (r 2 >0.95), our large-analysis population individuals aggressive (n = 532) chronic 1052), 2873 healthy control...
Abstract Periodontitis is associated with significant alveolar bone loss. Patients iron overload suffer more frequently from periodontitis, however, the underlying mechanisms remain largely elusive. Here, we investigated role of transferrin receptor 2 (Tfr2), one main regulators homeostasis, in pathogenesis periodontitis and dental phenotype under basal conditions mice. As Tfr2 suppresses osteoclastogenesis, hypothesized that deficiency may exacerbate periodontitis‐induced Mice lacking ( −/−...
Abstract Aim Identification of variants within genes SLC 23A1 and 23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) chronic periodontitis ( CP ). Material Methods Employment three independent case–control samples AgP (I. 283 cases, 979 controls; II . 417 1912 III 164 357 controls) one sample (1359 1296 controls). Results Stage 1: Among the tested single‐nucleotide polymorphisms SNP s), rare allele RA ) rs6596473 in showed nominal significant association p =...
Epidemiological and clinical studies indicated a relationship of periodontitis with rheumatoid arthritis (RA). We aimed to identify shared genetic susceptibility loci RA periodontitis.Forty-seven risk genes genome-wide significance SLE were genotyped in German case-control sample aggressive (AgP), using Immunochip genotyping arrays (Illumina, 600 cases, 1440 controls) Affymetrix 500 K Genotyping Arrays (280 cases 983 controls). Significant associations replicated 168 Dutch AgP 679 controls...
Abstract Aim: The autosomal‐recessive Papillon–Lefèvre syndrome (PLS) is characterized by severe aggressive periodontitis, combined with palmoplantar hyperkeratosis, and caused mutations in the Cathepsin C ( CTSC ) gene. This study aimed to identify different PLS phenotypes, including atypical forms isolated pre‐pubertal periodontitis (PAP). Material Methods: Thirteen families phenotypes were analysed direct sequencing of entire coding region regulatory regions . function novel was tested...
Abstract Aim: We aimed to assess the association of different genotypes with increased aggressive periodontitis susceptibility by studying functional relevant variants in pathogen‐recognition receptor Toll‐like 4 (TLR4) and promoter region pro‐inflammatory cytokine interleukin‐18 (IL‐18). Material Methods: One hundred eleven patients 80 periodontally healthy controls were genotyped for four TLR4 gene (c.896A>G c.1196C>T) IL‐18 (c.−368G>C c.−838C>A). The genotype allele...
Cathepsin C ( CTSC) mutations are known to cause Papillon-Lefèvre syndrome. The aim of this study was examine the association CTSC genotype with susceptibility non-syndromic aggressive periodontitis. gene analyzed in 110 persons generalized periodontitis comparison 78 control individuals, after identifying different variants a cohort 100 persons. Five out 19 discovered were included study, representing 5 single-nucleotide polymorphism groups tight linkage disequilibrium. relevance genotypes...