A5088370979- Gut microbiota and health
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Metabolism, Diabetes, and Cancer
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Pharmacological Effects of Natural Compounds
- Cardiovascular Disease and Adiposity
- Neurological Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin C and Antioxidants Research
- Inflammasome and immune disorders
- Intensive Care Unit Cognitive Disorders
- Vitamin D Research Studies
- Hydrogen's biological and therapeutic effects
- Vagus Nerve Stimulation Research
Federal Almazov North-West Medical Research Centre
2019-2025
Ministry of Health of the Russian Federation
2019-2025
Institute of Experimental Medicine
2019-2024
First Pavlov State Medical University of St. Petersburg
2021
Cardiovascular diseases (CVD) are the leading cause of death and disability worldwide. Low-grade chronic inflammation plays a major role in progression CVD. The review examines interleukin-1 (IL-1) family cytokines development IL-1 play an important atherosclerosis, myocardial infarction (MI), heart failure (CHF). presents data on mechanisms action effectiveness anti-IL-1 drugs prevention Also, this review, we consider possibility using changes composition intestinal microbiota as method...
In this study, we investigated the effect of three different probiotics, namely, a combination Lactobacillus acidophilus (LA–5) and Bifidobacterium animalis subsp. lactis (BB–12), Saccharomyces boulardii, Enterococcus faecium L3 on myocardial infarct size in rats with diet-induced obesity (DIO) chemically-induced colitis (CIC). Potential associations between effects probiotics ischemia-reperfusion injury gut microbiome patterns as well serum levels pro- anti-inflammatory cytokines,...
Our objective was to develop a model of systemic inflammatory response syndrome (SIRS) by chemical induction colon injury and antibiotic-associated intestinal dysbiosis in rats with primary visceral obesity (PVO) for studies myocardial resistance ischemia-reperfusion injury. The experiments were performed adult Wistar male PVO under improved conditions conventional animal clinic. chemically induced disease (CIICD) accomplished intragastric administration mixture broad-spectrum antimicrobial...
Abstract Impaired glucose tolerance (IGT) increases cardiovascular risk and can enlarge myocardial infarction (MI) incidence severity. There is lack of information about cardioprotective potential glucose-lowering drugs in IGT. We aimed to evaluate the sustainability myocardium ischemia–reperfusion injury diabetic IGT rats study action metformin liraglutide. Type 2 diabetes mellitus (DM) were modelled Wistar by high-fat diet streptozotocin + nicotinamide. 4 weeks after divided into groups:...
Background Recent evidence suggests that antibiotic-induced changes in the composition of intestinal microflora, as well systemic immunoendocrine effects result from them, can modulate myocardial tolerance to ischemia-reperfusion injury. The aim this study was investigate tetracycline (TTC) on infarct size isolated hearts obtained obese rats with chemically-induced colitis (CIC). association between TTC-induced and microbiome plasma levels cytokines short-chain fatty acids (SCFAs) also...
Overweight and obesity are among the main factors of cardiovascular risk, but prospective studies on dependence between high-fat diets weight gain yielded contradictory results. Different types fats exert varying metabolic effects, this fact leads to a difference in risk associated with increasing body weight. The effects fat quality daily diet immunological status resistance myocardium ischemic-reperfusion damage should be studied experimentally biomedical models. purpose work was assess...
We report an analysis of published data concerning the measurement systemic hemodynamic parameters in experiments on laboratory animals. The article highlights influence such issues as housing and husbandry, handling, frequency person contact, animal surgical modification pharmacological support perioperative period blood pressure heart rate, most frequently recorded both experiment clinic. Published should be taken into account when planning preparing using biomedical models, well...
The last 10–15 years have been marked by a rapid increase in the volume of knowledge about role intestinal microbiota regulation various physiological processes. In particular, interrelations between disturbances composition microflora and an risk developing cardiovascular diseases were noted. There are also emerging works that demonstrate possibility reducing severity myocardial ischemia-reperfusion injury as result effects on microbiota. This review analyzes recent literature influence...
Aim . To study the effect of lyophilized L. delbrueckii D5 , as well its inactivated culture, during intragastric administration on myocardial resistance to ischemia – reperfusion injury (IRI), markers inflammation, and intestinal epithelial permeability. Materials methods The experiments were performed male Wistar rats with a model systemic inflammatory response syndrome (SIRS). Myocardial IRI was reproduced an isolated Langendorff heart. Results A significant increase in levels tumor...
Within the concept of a heart-gut axis, new works are emerging to support efficacy probiotic strains increase myocardial resistance ischemia-reperfusion injury (IRI) in comorbidity. The question remains open whether presence live bacteria is necessary condition for realization their cardioprotective effect. aim this work was determine manifestation cardio-protective effect living and pasteurized Lactobacillus acidophilus (LA-5) Bifidobacterium animalis subsp. lactis (BB-12) rats with...
The intestinal microbiota not only mediates the influence of a number risk factors for cardiovascular diseases on body, but can also play an active role in regulation blood pressure (BP) by changing permeability epithelial barrier and production vasoactive metabolites. At same time, study molecular mechanisms underlying BP levels is at early stage. review analyzes scientific literature development arterial hypertension (HTN), describes key prohypertensive action metabolites, presents data...
The lack of donor hearts for transplantation in patients with end-stage chronic heart failure makes us look new ways to increase the pool donors. One possible base may be use asystolic donors, i. e. in-hospital cardiac arrest or after brain death. aim study was examine morphofunctional state various periods normothermic asystole an experiment on rats. Materials and methods . Experiments were performed female Wistar After cervical dislocation registration respiratory arrest, body temperature...