A5102857088- Reconstructive Facial Surgery Techniques
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Facial Rejuvenation and Surgery Techniques
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Facial Nerve Paralysis Treatment and Research
- Nerve injury and regeneration
- Nasal Surgery and Airway Studies
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- Botulinum Toxin and Related Neurological Disorders
- Neural dynamics and brain function
- Cleft Lip and Palate Research
- Stress Responses and Cortisol
- Hair Growth and Disorders
- Reconstructive Surgery and Microvascular Techniques
- EEG and Brain-Computer Interfaces
- Drug Transport and Resistance Mechanisms
- Ear Surgery and Otitis Media
- Musculoskeletal pain and rehabilitation
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2024
Universidad de Salamanca
2006-2023
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2000-2018
Hospital Ruber Internacional
1998-2011
Asepeyo Hospital Sant Cugat
1989
Significance Disruption of neuronal dendrites causes cognitive impairment in Alzheimer’s disease (AD). Rock2, a kinase the Rho family proteins, is dendrite destabilizer that accumulates AD brain. However, why Rock2 aberrantly aggregates, causing integrity loss, unknown. Here, we show protein stability controlled by ubiquitin ligase APC/C Cdh1 . Accordingly, loss function adult neurons increases and activity, disruption cortex hippocampus, along with memory neurodegeneration, mice. These...
Malar mounds may be accentuated by chronic lid edema, with the development from malar edema to and finally festoons. Because standard techniques do not seem effective specifically proposed for treatment of festoons, subperiosteal vertical upper-midface lift associated lower blepharoplasty overcomes these shortcomings.Twelve patients (3 males 9 females, age = 47 ± 6 years) underwent video-assisted endoscopic (SUM-lift) in conjunction a between 2006 2007 This includes simultaneous...
Intracellular recordings in slice preparations of the basolateral amygdala were used to test which excitatory amino acid receptors mediate postsynaptic potentials due stimulation external capsule. These also examine action muscarinic agonists on evoked potentials. from amygdaloid pyramidal neurons revealed that carbachol (2-20 microM) suppressed, a dose-dependent manner, responses by capsule (EC). This effect was blocked atropine. The estimated effective concentration produce half-maximal...
Reflex locomotion therapy (RLT) was developed by Vaclav Vojta in 1954 as a diagnostic and treatment tool. This is mainly used to rehabilitate children with motor disorders risk of cerebral palsy. It also for adults neurological impairment. RLT based on specific postures regular stimulation points through which series reflex responses are triggered. The neurophysiological mechanisms this have recently been discovered. study aims objectively evaluate muscular at the abdominal level after first...
The treatment of facial asymmetries presents an aesthetic component great importance. To correct contour defects, there are many therapeutic possibilities available, such as autologous tissue grafts and inorganic implants. arrival microsurgical techniques has improved the outlook for restoration. Among tissues used groin, escapular, omentum flaps. This article introduces our experience with latissimus dorsi free flap restoration defects. Our is based on 7 patients affected hemifacial...
We previously demonstrated that the administration of GH immediately after severe motor cortex injury, in rats, followed by rehabilitation, improved functionality affected limb and reexpressed nestin contralateral cortex. Here, we analyze whether these effects depend on a time window injury reexpression actin. Injured animals were treated with (0.15 mg/kg/day) or vehicle, at days 7, 14, 35 cortical ablation. Rehabilitation was applied short long term (LTR) lesion then sacrificed. Nestin...
Abstract The medial septum/diagonal band region, which participates in learning and memory processes via its cholinergic GABAergic projection to the hippocampus, is one of structures affected by beta amyloid (βA) deposition Alzheimer's disease (AD). acute effects βA (25–35 1–40) on action potential generation glutamatergic synaptic transmission slices septal area rat brain were studied using current patch‐clamp techniques. mechanism through M1 muscarinic receptors voltage‐dependent calcium...
To improve brow ptosis and forehead rhytids, minimal invasive surgery has successfully been applied more recently. Clinical studies have revealed that inadequate fixation for anchoring a transposed released soft tissue will result in loss of suspension the lateral eyebrow. Therefore, we evaluated results eyebrow position series endoscopic-assisted lift cases by comparing broad base with an Endotine device versus conventional single-point suture loop tissue. Between 2003 2005, 47 patients (12...
Lesions in specific areas of the rat motor cortex generate deficits related to fine movement performance affecting forelimb. We have previously shown that transplants embryonic frontal ameliorate these deficits. Amelioration has been associated with a functional integration transplant due connections established between host brain and graft. In current investigation, electrophysiological properties transplanted cells both intra-transplant adjacent are analyzed. For this purpose, adult rats...
Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the affectation produced by lesion induced re-expression of nestin contralateral cortex. Here analyze proliferation ablation frontal cortex investigate role striatum thalamus recovery. The rats were subjected to dominant hemisphere or sham-operated treated GH vehicle (V), for five days. At 1 dpi (days post-injury),...
Background: Vojta Therapy is a neurorehabilitation therapy that allows to activate reflex movement patterns. The scientific literature has shown its ability generate muscle contractions. activation of brain neural networks also been proven. However, the relationship between these processes not yet demonstrated. For this reason, aim study verify produced by recording with near-infrared spectroscopy and in abdominal muscles recorded surface electromyography. Methods: A total sample 27 healthy...
Minimally invasive surgery has been used successfully recently to improve brow ptosis and forehead rhytids. Because the face tends age more vertically, rather than obliquely, it makes sense perform correction in a vertical direction. Therefore, authors introduce video-assisted endoscopic transtemporal approach allow multiplanar (subperiosteal, sub-SMAS, subcutaneous) upper midface elevation (MUM-Lift) avoiding extensive lateral temporal preauricular incisions. Between 1996 2003, 53 patients...
Using an immunohistochemical technique, we have studied the distribution of kynuneric acid (KYNA) and 3-hydroxyanthranilic (3-HAA) in a rat brain injury model (trauma). The study was carried out inducing cerebral ablation frontal motor cortex. Two mouse monoclonal specific antibodies previously developed by our group directed against KYNA 3-HAA were used. In control animals (sham-operated), expression both not observed. which performed, highest number immunoreactive cells containing or...