A5006815708- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Per- and polyfluoroalkyl substances research
- Climate Change and Health Impacts
- Gestational Diabetes Research and Management
- Air Quality and Health Impacts
- Trauma Management and Diagnosis
- Nutritional Studies and Diet
- Endometriosis Research and Treatment
- Sexual Differentiation and Disorders
- Pregnancy and Medication Impact
- Abdominal Trauma and Injuries
- Hormonal and reproductive studies
- Toxic Organic Pollutants Impact
- Demographic Trends and Gender Preferences
- Reproductive System and Pregnancy
- Phytoestrogen effects and research
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
Saint Vincent Hospital
2025
Reproductive Science Center
2021-2024
New Hope Fertility Center
2013-2024
Boston University
2021-2023
Earth University
2023
United States Department of Health and Human Services
2022
Brigham and Women's Hospital
2011-2019
Philadelphia University
2018
Evidence from both animal and human studies suggests that exposure to phthalates may be associated with adverse female reproductive outcomes.We evaluated the associations between urinary concentrations of phthalate metabolites outcomes assisted technologies (ART).This analysis included 256 women enrolled in Environment Reproductive Health (EARTH) prospective cohort study (2004-2012) who provided one two urine samples per cycle before oocyte retrieval. We measured 11 [mono(2-ethylhexyl)...
STUDY QUESTIONAre urinary phthalate metabolites associated with reduced antral follicle growth among women in an infertility setting?
<h3>Importance</h3> Animal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number live-born offspring. Whether same is true in humans unknown. <h3>Objective</h3> To examine association preconception intake residues fruits and vegetables (FVs) with outcomes infertility treatment assisted reproductive technologies (ART). <h3>Design, Setting, Participants</h3> This analysis included 325 women who completed a diet assessment...
The Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, lifestyle factors among both women men on fertility pregnancy outcomes. EARTH recruits 18 45 years 55 seeking evaluation treatment at Massachusetts General Hospital (MGH) Fertility Center, Boston, USA. Women are eligible join either independently or as a couple. Participants followed from study entry throughout each cycle, once...
Deep learning in vitro fertilization is currently being evaluated the development of assistive tools for determination transfer order and implantation potential using time-lapse data collected through expensive imaging hardware. Assistive algorithms that can work with static images, however, help improving access to care by enabling their use images acquired from traditional microscopes are available virtually all fertility centers. Here, we a deep convolutional neural network (CNN), trained...
Animal studies demonstrate that several phthalates are embryofetotoxic and associated with increased pregnancy loss malformations. Results from human on inconsistent.We examined prospectively in relation to urinary phthalate metabolite concentrations among women undergoing medically assisted reproduction. We used data 256 conceiving 303 pregnancies recruited between 2004 2012 the Massachusetts General Hospital Fertility Center. quantified 11 calculated molar sum of four di(2-ethylhexyl)...
To evaluate the consistency and objectivity of deep neural networks in embryo scoring making disposition decisions for biopsy cryopreservation comparison to grading by highly trained embryologists.
Parental preconception exposure to select phenols and phthalates was previously associated with increased risk of preterm birth in single chemical analyses. However, the joint effect phenol phthalate mixtures on is unknown. We included 384 female 211 male (203 couples) participants seeking infertility treatment Environment Reproductive Health (EARTH) Study who gave singleton infants between 2005 2018. Mean urinary concentrations bisphenol A (BPA), parabens, eleven biomarkers, including...
Parabens are preservatives commonly used in personal care products, pharmaceuticals, and foods. There is documented widespread human exposure to parabens, some experimental data suggest that they act as estrogenic endocrine disruptors. As far we aware, no epidemiologic studies have assessed female reproductive health effects relation paraben exposure.We examined the association of urinary concentrations with markers ovarian reserve a prospective cohort study women seeking fertility treatment...
Are serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes?Serum levels of long-chain ω3-PUFA were positively associated with probability live birth among women undergoing ART.Intake improves oocyte embryo quality in animal human studies. However, a recent cohort study found no relation between circulating pregnancy rates after ART.This analysis included random sample 100 from prospective (EARTH) at the...
An increasing number of studies have linked air pollution to decreased fertility. Whether this is due an effect on ovarian reserve unknown.Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m (PM2.5) (based residential address) for 3 months before We analyzed associations with Poisson regression.Every 2 increase in PM2.5...
Background: While overt thyroid disease is a well known risk factor for infertility, the potential consequences of mild dysfunction or autoimmunity remain unknown. Experimental studies suggest considerable role hormone in physiological mechanisms ovarian reserve, but translation such findings to human remains rare. A function female reproduction could be especially relevant when cause infertility unknown, as women with diminished reserve (DOR) unexplained infertility. The aims this study...
A critical factor that influences the success of an in-vitro fertilization (IVF) treatment cycle is quality transferred embryo. Embryo morphology assessments, conventionally performed through manual microscopic analysis suffer from disparities in practice, selection criteria, and subjectivity due to experience embryologist. Convolutional neural networks (CNNs) are powerful, promising algorithms with significant potential for accurate classifications across many object categories. Network...
Prenatal per and polyfluoroalkyl substances (PFAS) exposure is associated with adverse birth outcomes. There an absence of evidence on the relationship between maternal paternal preconception PFAS This study included 312 mothers 145 fathers a singleton live from cohort subfertile couples seeking fertility treatment at U.S. clinic. were quantified in serum samples collected before conception. Gestational age (GA) birthweight (BW) abstracted delivery records. We also assessed low (BW < 2500 g)...
Objective The changing profiles of spinal cord injuries in South Africa are addressed this study. Design A retrospective analysis 551 patients with injury. Materials and Methods cause injury was motor vehicle crashes 30%, stab wounds 26%, gunshot 35%, miscellaneous causes 9%. Measurements Main Results There a significant shift from towards bullet over the last five years. Bullet increased 30 cases 1988 to 55 1992, while decreased 39 20 1992. incidence following crash showed declining...