A5015624993- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Air Quality and Health Impacts
- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Microplastics and Plastic Pollution
- Noise Effects and Management
- Smoking Behavior and Cessation
- Cell death mechanisms and regulation
- Carbon Nanotubes in Composites
- Occupational exposure and asthma
- Heavy Metal Exposure and Toxicity
- Healthcare and Environmental Waste Management
- Computational Drug Discovery Methods
- Bone Tissue Engineering Materials
- Toxic Organic Pollutants Impact
- Vehicle emissions and performance
- NF-κB Signaling Pathways
- Legionella and Acanthamoeba research
- Polymer Surface Interaction Studies
- Air Quality Monitoring and Forecasting
- Advanced Nanomaterials in Catalysis
- Global Public Health Policies and Epidemiology
- Electrostatics and Colloid Interactions
- Energy and Environment Impacts
Inserm
2016-2025
Mines Saint-Étienne
2016-2025
Biologie, ingénierie et imagerie pour l'Ophtalmologie
2016-2024
Université Jean Monnet
2018-2024
Institut du Thorax
2024
Université Claude Bernard Lyon 1
2016-2022
Établissement Français du Sang
2021-2022
Georges Friedel Laboratory
2017
École Nationale d'Ingénieurs de Saint-Étienne
2010-2016
Biologie des Plantes et Innovation
2013-2015
Constitutive activation of growth factor signaling pathways paradoxically triggers a cell cycle arrest known as cellular senescence. In primary cells expressing oncogenic ras, this mechanism effectively prevents transformation. Surprisingly, attenuation ERK/MAP kinase by genetic inactivation Erk2, RNAi-mediated knockdown ERK1 or ERK2, MEK inhibitors prevented the senescence mechanism, allowing ras to transform cells. Mechanistically, ERK-mediated involved proteasome-dependent degradation...
The concern about titanium dioxide nanoparticles (TiO2-NPs) toxicity and their possible harmful effects on human health has increased. Their biological impact is related to some key physicochemical properties, that is, particle size, charge, crystallinity, shape, agglomeration state. However, the understanding of influence such features TiO2-NP remains quite limited. In this study, cytotoxicity, proinflammatory response, oxidative stress caused by five types TiO2-NPs with different...
Because it is impossible to assess in vitro or vivo the toxicity of all nanoparticles available on market a case-by-case basis, computational approaches have been proposed as useful alternatives predict silico hazard potential engineered nanoparticles. Despite promising results, major issue associated with these mathematical models lies priori choice physicochemical descriptors and biological end points. We performed thorough bibliographic survey points used for nanotoxicology purposes...