A5034741970- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Gene expression and cancer classification
- Multimedia Communication and Technology
- Lung Cancer Treatments and Mutations
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Aortic Disease and Treatment Approaches
- DNA Repair Mechanisms
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Pancreatic and Hepatic Oncology Research
- HIV Research and Treatment
- Immunotoxicology and immune responses
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Software Engineering Techniques and Practices
- Graphite, nuclear technology, radiation studies
- Transport and Economic Policies
- Autoimmune and Inflammatory Disorders
- Advanced Breast Cancer Therapies
- Coronary Artery Anomalies
- Esophageal Cancer Research and Treatment
- Historical and Cultural Archaeology Studies
- Distributed and Parallel Computing Systems
University of Virginia
2022
Arkansas Children's Hospital
2021
University of Arkansas for Medical Sciences
2021
University of California, San Diego
2019-2020
University of Tennessee Health Science Center
2019
University of Arkansas at Little Rock
2001
United States Department of Veterans Affairs
2001
Vanderbilt University
1989-2000
University of California, Davis
1995
University of California, Irvine
1995
To review available drug-resistance patterns of HIV proteinase inhibitors, in particular saquinavir (formerly known as Ro 31-8959), focusing on the implications for disease management.Reduced sensitivity to appears develop slowly and at low frequency even during prolonged therapy, with an incidence approximately 45% 1 year monotherapy. This reduced is consistently associated presence two independent mutations gene, glycine-->valine position 48 leucine-->methionine 90, latter predominating...
Visual deficits after traumatic brain injury (TBI) are common, but interventions that limit the post-trauma impairments have not been identified. We found treatment with cannabinoid type-2 receptor (CB2) inverse agonist SMM-189 for 2 weeks closed-head blast TBI greatly attenuates visual and retinal pathology this otherwise produces in mice, by modulating deleterious role of microglia process trauma. SMM-189, however, has yet approved human use. Raloxifene is an FDA-approved estrogen drug...
A preliminary study is made of simultaneous and lagged seasonal cross correlations between northern Australian sea level district rainfall anomalies. Zero-lagged patterns show strong links with the El Niño/Southern Oscillation (ENSO) phenomenon over eastern Australia during austral winter-spring seasons. These findings are similar to, but more robust than, those reported for either southern oscillation index, Darwin mean pressure, or surface temperatures. This appears to be a consequence...
Keywords PHILADELPHIA & READING RAILWAY RAILWAYS, PERMANENT WAY, CONSTRUCTION, METHODS, RAILROADS, IRON, WROUGHT, JOINTS, CHAIRS, FASTENINGS, RAILS, METALS, TRACK, TIMBER, TRELLIS PHILADELPHIA, READING, BALTIMORE, SUSQUEHANNA UNITED STATES, USA... Show All
To investigate whether alteration in interferon (IFN) production might serve as a biomarker for certain toxic chemical exposures, an vivo mouse model system was studied. Female C3H mice were injected intraperitoneally with varying doses of benzo[a]pyrene (BP), and at various times subsequent to this treatment, serum IFN levels, following Sendai virus induction, determined by cytopathic effect inhibition assay. Doses 4.6 mg/mouse (180 mg/kg body weight) caused significant depression 12, 48,...
Aortic complications during cannulation must be managed urgently and often require hypothermic circulatory arrest. We report a unique management strategy to repair an aortic tear without dissection by modifying Dacron ascending graft with side-arm.A 32-year-old female patient undergoing reoperative cardiac surgery suffered unexpected for cardiopulmonary bypass. The was repaired utilizing physician-modified side-arm, in which the surrounding skirt of side-arm cut from circumferential patch...
Coronary sinus ostial obstruction is an exceedingly rare anomaly that particularly important to diagnose in patients with single-ventricle heart disease before surgical palliation. We present 2 cases, infant and adult, diagnosed coronary obstruction, different clinical outcomes due timing of diagnosis. (Level Difficulty: Intermediate.)
<div>Abstract<p><b>Purpose:</b> Chromosomal instability is a fundamental property of cancer, which can be quantified by next-generation sequencing (NGS) from plasma/serum–derived cell-free DNA (cfDNA). We hypothesized that cfDNA could used as real-time surrogate for imaging analysis disease status function response to immunotherapy and more reliable tool than tumor biomarkers.</p><p><b>Experimental Design:</b> Plasma sequences 56 patients with...
<div>Abstract<p><b>Purpose:</b> Chromosomal instability is a fundamental property of cancer, which can be quantified by next-generation sequencing (NGS) from plasma/serum–derived cell-free DNA (cfDNA). We hypothesized that cfDNA could used as real-time surrogate for imaging analysis disease status function response to immunotherapy and more reliable tool than tumor biomarkers.</p><p><b>Experimental Design:</b> Plasma sequences 56 patients with...
Supplementary Data from Next Generation Sequencing of Serum Circulating Nucleic Acids Patients with Invasive Ductal Breast Cancer Reveals Differences to Healthy and Nonmalignant Controls
<div>Abstract<p>Circulating nucleic acids (CNA) isolated from serum or plasma are increasingly recognized as biomarkers for cancers. Recently developed next generation sequencing provides high numbers of DNA sequences to detect the trace amounts unique associated with breast carcinoma. Serum CNA 38 women ductal carcinoma was extracted and sequenced on a 454/Roche high-throughput GS-FLX platform compared healthy controls patients other medical conditions. Repetitive elements...
Supplementary Data from Next Generation Sequencing of Serum Circulating Nucleic Acids Patients with Invasive Ductal Breast Cancer Reveals Differences to Healthy and Nonmalignant Controls