A5103016167- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Advancements in Transdermal Drug Delivery
- Periodontal Regeneration and Treatments
- Dental materials and restorations
- Antimicrobial agents and applications
- Dental Radiography and Imaging
- Wound Healing and Treatments
- Bone and Dental Protein Studies
- Burn Injury Management and Outcomes
- Orthodontics and Dentofacial Orthopedics
- Dental Research and COVID-19
- Spectroscopy and Chemometric Analyses
- Surfactants and Colloidal Systems
- Drug Solubulity and Delivery Systems
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Advanced Drug Delivery Systems
- Aquaculture disease management and microbiota
- Temporomandibular Joint Disorders
- Bee Products Chemical Analysis
- Natural Compound Pharmacology Studies
- Bacterial biofilms and quorum sensing
- Reconstructive Surgery and Microvascular Techniques
- Inhalation and Respiratory Drug Delivery
Universidade do Estado do Rio de Janeiro
2010-2024
Pontifícia Universidade Católica de São Paulo
2024
Novartis (Switzerland)
2014-2023
Universidade Federal Rural do Rio de Janeiro
2020
University of Coimbra
2017
University of London
2008-2011
Royal Pharmaceutical Society
2008
Acrux (Australia)
2008
Charité - Universitätsmedizin Berlin
2008
Abstract The YAP-TEAD protein-protein interaction (PPI) is a critical event known to mediate YAP oncogenic functions downstream of the Hippo pathway. Current advanced pharmacological agents which aim at inhibiting function do so by engaging into lipid pocket TEAD. Thereby consequences direct disruption interface and TEADs remain unexplored. Here we report identification IAG933, first molecule able potently directly disrupt YAP/TAZ-TEADs PPI with suitable properties enter in clinical trial....
Journal Article Association of Aeromonas caviae polar and lateral flagella with biofilm formation Get access P.G. Santos, Santos Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade Ciências Médicas, Universidade do Estado Rio Janeiro, RJ, Brazil Search for other works by this author on: Oxford Academic Google Scholar P.A. A.R. Bello, Bello A.C. Freitas‐Almeida Angela C. Freitas‐Almeida, Avenida 28 Setembro 87, 3º andar, Fundos, Vila Isabel, RJ 20551‐030, Brazil. E‐mail:...
Synthetic biomaterials have played an increasingly prominent role in the substitution of naturally derived current surgery practice. In vitro and vivo characterization studies new synthetic are essential to analyze their physicochemical properties underlying mechanisms associated with modulation inflammatory process bone healing.This study compares tissue behavior a biomaterial nano-hydroxyapatite/beta-tricalcium phosphate (nano-HA/ß-TCP mixture) deproteinized bovine mineral (DBBM) rat...
We describe the synthesis and characterization of 3-alkoxy-pyrrolo[1,2-b]pyrazolines as novel selective androgen receptor (AR) modulators that possess excellent physicochemical properties for transdermal administration. Compound 26 bound to human AR with an IC50 0.7 nM great selectivity over other nuclear hormone receptors potently activated in a C2C12 muscle cell reporter gene assay EC50 0.5 nM. It showed high aqueous solubility 1.3 g/L at pH 7.4, silico model well customized parallel...
The first treatments with dental implants had low success rates (75%). Nowadays, oral rehabilitation titanium has a high rate (95-98%). significantly increases due to increased scientific knowledge about osseointegration, changes in surgical techniques, and the development of implant surface treatments. Despite implants, no protocol defines time for prosthesis be installed loaded after surgery. This work compares new implant's primary (mechanical) secondary (osseointegration)...
In past decades, the success rates of first dental implant treatments were low (75%). Nowadays, oral rehabilitation with titanium implants has a high rate (95%–98%). The significantly increases due to increased scientific knowledge about osseointegration, changes in surgical techniques, and development surface treatments. Despite implants, there are no protocols define time for prosthesis be installed, insertion torque, loaded after surgery. This work compares new implant’s primary...
Bone defects are a challenging clinical situation, and the development of hydroxyapatite-based biomaterials is prolific research field that, in addition, can be joined by stem cells growth factors order to deal with problem. This study compares use synthetic hydroxyapatite xenograft, used pure or enriched bone marrow mononuclear fraction for regeneration critical size rat calvaria through histomorphometric (Masson’s staining) immunohistochemical (anti-VEGF, anti-osteopontin) analysis. Forty...
Infections of burn wounds are the source significant problems in patients. Early excision eschar tissue is an ideal solution to avoid sepsis. When early not feasible, application topical antimicrobial formulations may be used control wound An understanding barrier properties essential for optimal design formulations. To date, little research has been conducted on permeability eschar. Silver sulphadiazine (SSD) most frequently agent management. In this study, permeation from aqueous saturated...
Following the worldwide trend of developing heavy metal free materials, dental implants aren’t out this tendency. Over years, a number techniques to condition surface have been designed and used such as oxide blasting, however scientific medical community has concerned about use these metals which leads us investigate develop new conditioning techniques. The aim study was analysis Systhex® implant in automatic system for treatment with acid, where we can identify surfaces purity level, pore...
ABSTRACT Guided bone regeneration aims to gain vertical and horizontal volume in atrophic ridges, using different regenerative techniques associated with biomaterials, occasional post-surgical complications. The objective of the case report was describe successive approaches minimize eliminate complications presented postoperative period a patient submitted guided technique. In first surgery, dense expanded polytetrafluoroethylene membrane (d-PTFE), supported by tent technique autogenous...
O principal tratamento para restaurar a mastigação e estética em pacientes edêntulos é reabilitação com implantes dentários de titânio. Há quatro décadas, os tratamentos apresentavam baixas taxas sucesso (75%). Com o aumento do conhecimento científico sobre osseointegração, mudanças nas técnicas cirúrgicas, desenvolvimento superfície dos alterações formas filetes implantes, taxa aumentou. Este estudo analisou estabilidade primária secundária (osseointegração) um novo implante dentário ataque...
Background: Narrow-diameter implants (3.0 - 3.5 mm range) have been introduced for the replacement of teeth with insufficient bone structure and/or limited mesiodistal or interimplant spaces, and appear to offer clinical results similar those obtained greater diameter. Studies using extra-narrow-diameter (2.8 mm) are scarce. Case Presentation: A 59-year-old male patient received two implants, 2.8 × 11 in region between elements 14. Together, 8.5 SYSTHEX® platform 4.1 were installed 15 16...
ObjectiveThe two major causes for implant failure are postoperative infection and poor osteogenesis.Initial period of osteointegration is regulated by immunocytes osteogenic-related cells resulting in inflammatory response tissue healing.The healing phase can be influenced various environmental factors biological cascade effect.To synthetically orchestrate bone-promoting on biomaterial surface, we built a dual delivery system coated titanium surface (abbreviated as AH-Sr-AgNPs).
alfa-Mangostin (MGT) is the main product isolated from fruit pericarp of Garcinia mangostana. This xanthone exhibits important toxic effects on T. cruzi forms amastigotes. We describe herein synthesis new hybrid derivatives MGT and nitroimidazoles using click reaction as key-step. Toxic intracellular amastigotes (Tulahuen C2C4 LacZ).