A5060544203- Hippo pathway signaling and YAP/TAZ
- Cancer-related Molecular Pathways
- Aquatic Invertebrate Ecology and Behavior
- Cell death mechanisms and regulation
- CAR-T cell therapy research
- Species Distribution and Climate Change
- Subterranean biodiversity and taxonomy
- Mollusks and Parasites Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Cancer Immunotherapy and Biomarkers
- Plant and animal studies
- Monoclonal and Polyclonal Antibodies Research
- Parasite Biology and Host Interactions
- Microtubule and mitosis dynamics
- Genetic diversity and population structure
Novartis (Switzerland)
2023-2024
Novartis Institutes for BioMedical Research
2023
University College London
2019
Cancer Research UK
2019
London Cancer
2019
CRUK Lung Cancer Centre of Excellence
2019
National and Kapodistrian University of Athens
2013-2015
The YAP-TEAD protein-protein interaction mediates YAP oncogenic functions downstream of the Hippo pathway. To date, available pharmacologic agents bind into lipid pocket TEAD, targeting indirectly via allosteric changes. However, consequences a direct pharmacological disruption interface between and TEADs remain largely unexplored. Here, we present IAG933 its analogs as potent first-in-class selective disruptors with suitable properties to enter clinical trials. Pharmacologic abrogation all...
Abstract The YAP-TEAD protein-protein interaction (PPI) is a critical event known to mediate YAP oncogenic functions downstream of the Hippo pathway. Current advanced pharmacological agents which aim at inhibiting function do so by engaging into lipid pocket TEAD. Thereby consequences direct disruption interface and TEADs remain unexplored. Here we report identification IAG933, first molecule able potently directly disrupt YAP/TAZ-TEADs PPI with suitable properties enter in clinical trial....
Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), by loss-of-function mutations upstream components the Hippo pathway, while, Uveal Melanoma (UM), Hippo-independent manner. To date, unclear if how different oncogenic lesions activating impact its program, which particularly relevant for designing selective anti-cancer therapies. Here we show that, despite being essential both MPM...
BackgroundTumor-infiltrating lymphocytes (TILs) represent a prognostic factor for survival in primary breast cancer (BC). Nonetheless, neoepitope load and TILs cytolytic activity are modest BC, compromising the efficacy of immune-activating antibodies, which do not yet compete against immunogenic chemotherapy.Patients methodsWe analyzed by functional flow cytometry immune dynamics metastatic axillary nodes [metastatic lymph (mLN)] early BC (EBC) after exposure to T-cell bispecific antibodies...
For a remote oceanic archipelago of up to 8 Myr age, the Azores have comparatively low level endemism. We present an analysis phylogeographic patterns endemic Azorean island arthropods aimed at testing diversification in relation ontogeny archipelago, order distinguish between alternative models evolutionary dynamics on islands. collected individuals six species (representing Araneae, Hemiptera and Coleoptera) from 16 forest fragments 7 Using three mtDNA markers, we analysed distribution...
Isimerope semele n. gen. and sp., a valvatiform hydrobiid from southern continental Greece, is described based on morphological molecular data. distinguished other European circum-Mediterranean genera by unique combination of characters, including distinctive male female genitalia. differentiated morphologically similar Graecoarganiella, which also endemic to 10.15% mean COI sequence divergence. composed three small populations living in disturbed habitats, springs river.
In the present study, we revised Albanian Agathylla, combining traditional shell morphological approach with a phylogenetic reconstruction based on three mitochondrial DNA markers (COI, COII and 16S rRNA). From faunistic perspective, Albania was an almost completely unexplored country until end of 1990s. Following recent intense field sampling activity in Albania, number known Agathylla populations has increased, providing opportunity to investigate how additional material can contribute...