A5033857512- Chemotherapy-induced organ toxicity mitigation
- Biomedical Research and Pathophysiology
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Clinical Nutrition and Gastroenterology
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Metabolism and Genetic Disorders
- Renal and related cancers
- Abdominal vascular conditions and treatments
- Cancer Research and Treatments
- Hormonal and reproductive studies
- Pancreatitis Pathology and Treatment
University of Agriculture in Krakow
2019-2020
Urotoxicity is a characteristic attribute of cy-clophosphamide and ifosfamide. Acetylcysteine perceived as uroprotective possible nephroprotective compound. The purpose the study was to assess effect acetylcysteine treatment on morphology kidneys urinary bladder, renal function in rats with cystitis induced by cyclophosphamide or ifosfamide.Cystitis belonging groups 2 3, well 4 5, five administrations (75 mg/kg) ifosfamide (80 respectively. Additionally, 3 5 received (200 mg/kg). Group 1...
Aim: Cyclophosphamide (CP) is a cytostatic agent, which evokes numerous side effects, including well-known cystitis. Acrolein released during CP biotransformation exerts both urotoxic and nephrotoxic therefore may cause renal dysfunction. The aim of the study was to assess kidney function in experimental models acute chronic Material/Methods: studies were carried out on 40 rats (4 groups; n = 10), (single dose 150 mg/kg CP; group 2) or (four doses 75 4) cystitis induced with appropriate...
Ifosfamide (IF) is a cytostatic that exhibits adverse nephrotoxic properties. Clinically, IF-induced nephrotoxicity takes various forms, depending on applied dose and length of treatment.The aim the study was to evaluate two proteins: osteopontin (OP) fatty acid binding protein (FABP), as markers kidney function in rats treated with ifosfamide.Rats receiving single IF (250 mg/kg b.w.; group 1) or five consecutive doses administrated following days (50mg/kg 3), compared control groups 2 4,...
Background.Disturbances in pancreatic microcirculation, beginning with vasoconstriction, are crucial early pancreatitis and progression to necrotizing pancreatitis.Thus, vascular-targeted treatment aiming restore a sufficient level of microcirculation through vasodilation would possibly reduce the severity pancreatitis.Lidocaine is an anti-arrhythmic local anesthetic drug, which also acts as vasodilator at higher concentrations. Objectives.To evaluate efficacy intra-arterial infusion...
The administration of cyclophosphamide (CP) is associated with the risk developing cystitis as well kidney injury. aim study was to verify uroprotective effect N-acetylcysteine (NAC), evaluation renal function in experimental model acute CP-induced cystitis. Rats from group 1 received intraperitoneally only a single dose 200 mg/kg b.w. CP. Individuals groups 2 and 3 additionally NAC, respectively, orally (p.o.) (i.p.). After drugs, animals were subject individual monitoring metabolic cages...
Background: Renal damage and dysfunction are possible complications of pharmacotherapy with ifosfamide (IF), which also manifests urotoxic properties. A routine drug used to reduce the risk IF-induced cystitis is mesna. Compounds effect expected be similar mesna include N-acetylcysteine (NAC). Objective: The objective paper was histopathological verification uroprotective NAC assessment whether this accompanied by a potential nephroprotective effect. Methods: experiment conducted on 3...