A5023817005- Leptospirosis research and findings
- Veterinary medicine and infectious diseases
- Viral Infections and Vectors
- Chemotherapy-induced organ toxicity mitigation
- Animal Disease Management and Epidemiology
- Biomedical Research and Pathophysiology
- Sperm and Testicular Function
- Humic Substances and Bio-Organic Studies
- T-cell and Retrovirus Studies
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Pulmonary Hypertension Research and Treatments
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Gut microbiota and health
- Hormonal and reproductive studies
- Yersinia bacterium, plague, ectoparasites research
- Muscle and Compartmental Disorders
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Renal Diseases and Glomerulopathies
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Salmonella and Campylobacter epidemiology
University of Agriculture in Krakow
2016-2024
Jagiellonian University
2016-2023
Agri Food and Biosciences Institute
2012-2017
Government of Northern Ireland
2013-2015
In June 2023, a fatal disease outbreak in cats occurred Poland. Most cases tested Poland (29 of 47) were positive for highly pathogenic avian influenza (HPAI) A (H5N1) virus. Genetic analyses revealed clade 2.3.4.4b with point mutations indicative initial mammalian hosts adaptations. Cat viral sequences similar (n = 21), suggesting potential common infection source. To investigate possible routes, our group food samples from affected households. HPAI H5N1 virus was detected one poultry meat sample.
A total of 855 sera from dogs in Greece were tested for antibodies to strains belonging the Pomona, Grippotyphosa and Australis serogroups Leptospira assess exposure levels these serogroups, possible associations with clinical disease evaluate whether findings support inclusion additional serovars dog vaccines. Antibodies detected 110 (12·9%) dogs. The highest seroprevalence (4·9%) was proposed novel serovar Altodouro Pomona serogroup. This also showed a statistically significant association...
The greater white-toothed shrew (Crocidura russula) is an invasive mammalian species that was first recorded in Ireland 2007. It currently occupies area of approximately 7,600 km2 on the island. C. russula normally distributed Northern Africa and Western Europe, previously absent from British Isles. Whilst can have dramatic rapid impacts faunal floral communities, they may also be carriers pathogens facilitating disease transmission potentially naive populations. Pathogenic leptospires are...
The studies on microbiome in the human digestive tract indicate that fungi could also be one of external factors affecting development diabetes. aim this study was to evaluate quantitative and qualitative mycobiome composition colon adults with type 1 (T1D), n = 26 2 (T2D) diabetes, 24 compared control group, 26. gut characterized stool samples using analysis whole internal transcribed spacer (ITS) region fungal rDNA gene cluster by next-generation sequencing (NGS) increased sensitivity. At...
Recently an increase in the population of wild boars (Sus scrofa) Europe has been observed. This is important from a zoonotic perspective because it influences directly on spread many diseases. For first time, extensive survey prevalence Leptospira infections Polish was performed. During hunting season 2012–2014, 3621 blood samples were collected. The animals originated different geographical areas across Poland. Serum tested by microscopic agglutination test (MAT) for presence specific...
Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the virulence remain mostly unknown. Recently, it has been demonstrated that an AAA+ chaperone ClpB (a member Hsp100 family) from L. (ClpBLi) not only essential survival under thermal and oxidative stresses, but also during infection host. aim this study was to provide further insight into role pathogenic spirochaetes explore its biochemical properties. We found non-hydrolysable ATP...
Leptospira spp. are the causative agents of a worldwide zoonosis, leptospirosis, maintained by various mammals. Each serovar is frequently associated with particular maintenance host, and recently, genotype–host association has also been suggested to limit serovars restricted areas. We investigated molecular characteristics L. interrogans borgpetersenii which were isolated from small feral wild animals in four East Asian states using multiple-locus variable-number tandem repeat analysis...
Leptospira spp. infect humans and a wide range of domestic wild animals, but certain species such as small rodents red foxes (Vulpes vulpes) play particular role reservoirs transmission leptospirosis they easily adapt to many habitats including human environments. To investigate the significance in epidemiology Poland, seroprevalence survey was conducted. During 2014–2015 hunting season, blood samples 2134 originating from central-eastern part Poland were collected. Serum tested by...
Pulmonary arterial hypertension (PAH) is a rare, fatal, and incurable disorder. Although advances in the understanding of PAH pathobiology have been seen recent years, molecular processes underlying heart remodelling over course are still insufficiently understood. Therefore, aim this study was to investigate myocardial proteomic profile rats at different stages monocrotaline-induced PAH. Samples left right ventricle (LV RV) free wall collected from 32 Wistar were subjected analysis using an...
A total of 474 serum samples from client owned Irish dogs were tested for the presence antibodies to serovars Canicola, Icterohaemorrhagiae, Bratislava, Autumnalis, Pomona, Altodouro, Grippotyphosa, Mozdok, Hardjobovis and Ballum. Six per cent presented veterinary practitioners problems unrelated leptospirosis showed evidence prior exposure leptospiral belonging serogropus Ballum, Australis, Pomona Sejroe. One unvaccinated dog suspected have seroconversion serogroup Icterohaemorrhagiae....
The genus Leptospira, isolated for the first time in 1915, is one of most diverse genera bacteria which includes species worldwide. taxonomic classification was based on serological similarities strains. basic taxon serovar. More than 300 serovars are currently known. Furthermore, many years divided into two species, saprophytic Leptospira biflexa and pathogenic interrogans. introduction genetic techniques has led to a new classification. In this review, we described changes that have taken...
Abstract Background Testis is an immune privileged organ, which prevents the response against sperm antigens and inflammation. Testicular cells responsible for tolerance are mainly Sertoli cells, form blood-testis barrier produce immunosuppressive factors. prevent inflammation in testis maintain by inhibiting proliferation inducing lymphocyte apoptosis. It has been shown that 9-cis-retinoic acid (9cRA) blocks ex vivo apoptosis of peripheral blood lymphocytes promotes differentiation Treg...
Bacterial ClpB is an ATP-dependent Hsp100 chaperone that reactivates aggregated proteins in cooperation with the DnaK system and promotes survival of bacteria under stress conditions. A large number publications also indicate supports virulence bacteria, including a pathogenic spirochaete Leptospira interrogans responsible for leptospirosis both animals humans. However, exact role bacterial pathogenicity remains poorly characterized. It can be assumed ClpB, due to its as molecular chaperone,...
Abstract Background Aim of this study was to assess changes in cardiac morphometric parameters at different stages pulmonary arterial hypertension (PAH) using a monocrotaline-induced rat model. Methods Four groups were distinguished: I–control, non-PAH (n = 18); II–early PAH 12); III–end-stage 23); and IV–end-stage with myocarditis 7). Results Performed over the course vivo echocardiography showed significant thickening right ventricle free wall (end-diastolic dimension), tricuspid annular...
Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the virulence remain mostly unknown. Recently, it has been demonstrated that L. ClpB (ClpBLi) essential bacterial survival under stressful conditions and also during infection. aim this study was to provide further insight into role answer question whether ClpBLi as potential factor may be target humoral immune response leptospiral infections mammals.ClpBLi consists 860 amino acid...
We report here the complete genome sequence of Leptospira alstonii serovar Room22 strain GWTS #1. This is first isolate L. to be cultured from a mammal and in western Europe, it represents new pathogenic leptospires.