A5037465952- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Cancer-related gene regulation
- interferon and immune responses
- COVID-19 epidemiological studies
- Ubiquitin and proteasome pathways
- Integrated Circuits and Semiconductor Failure Analysis
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Immune Response and Inflammation
- Histone Deacetylase Inhibitors Research
- Clusterin in disease pathology
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Sex work and related issues
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Gout, Hyperuricemia, Uric Acid
Shandong University
2021-2025
Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as potential approach for tumor treatment. However, emerging evidence indicates that hepatocellular carcinoma (HCC) cells are generally resistant to ferroptosis the underlying molecular mechanism poorly understood. Here, our study confirms S100 calcium binding protein P (S100P), which significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis....
PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity.
Abstract Cyclic GMP-AMP synthase (cGAS), as a cytosolic DNA sensor, plays crucial role in antiviral immunity, and its overactivation induces excess inflammation tissue damage. Macrophage polarization is critically involved inflammation; however, the of cGAS macrophage during remains unclear. In this study, we demonstrated that was upregulated LPS-induced inflammatory response via TLR4 pathway, signaling activated by mitochondria macrophages isolated from C57BL/6J mice. We further mediated...
Persistent infection of high-risk human papillomavirus (HPV) and the expression E6 E7 oncoproteins are main causes cervical cancer. Several prophylactic HPV vaccines used in clinic, but these have limited efficacy patients already infected with HPV. Since is vital for tumor-specific immunity, developing a vaccine against an attractive strategy cancer treatment. Here, we constructed HPV16 mutant that loses ability to bind pRb while still eliciting robust immune response. In order build...
The immune inflammatory response changes rapidly with the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is responsible for clearance virus further recovery from infection. However, intensified in development disease may lead to more serious fatal consequences, which indicates that indicators have potential predict cases.
Abstract The NOD-like receptor protein (NLRP)3 inflammasome is the most extensively studied actively involved in various inflammatory diseases, however its regulatory mechanism not fully understood. Histone deacetylase (HDAC)10 a member of class II histone deacetylase, while whether it has any role activation known. Here we demonstrated that HDAC10 directly interacted with NLRP3 and induced deacetylation NLRP3, which further resulted suppression inhibition activation. Further investigation...