A5076259414- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Sports Performance and Training
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Diet and metabolism studies
- Genetics and Physical Performance
- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Sports injuries and prevention
- Metabolism and Genetic Disorders
- Cardiovascular Effects of Exercise
- Body Composition Measurement Techniques
- Chemotherapy-induced cardiotoxicity and mitigation
- Frailty in Older Adults
- Tendon Structure and Treatment
- Amino Acid Enzymes and Metabolism
- Pharmacological Effects and Assays
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Obesity, Physical Activity, Diet
- Metabolism, Diabetes, and Cancer
- Renal function and acid-base balance
Central Washington University
2006-2024
The University of Texas Medical Branch at Galveston
2012-2023
Arizona State University
2008-2021
Purdue University West Lafayette
2019
Texas Woman's University
2016
University of Maine at Presque Isle
2015
John Sealy Hospital
2013-2014
Auburn University
2014
Nutrition Sciences (Belgium)
2012
Ball State University
2007-2011
Abstract Background Sarcopenia, the loss of skeletal muscle mass during aging, increases risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve strength in older adults, but aging associated with a smaller amount training-induced hypertrophy. This may be due part inability stimulate muscle-protein synthesis (MPS) after acute bout RE. We hypothesized that adults would have impaired mammalian target rapamycin complex (mTORC)1 signaling MPS...
Skeletal muscle atrophy during bed rest is attributed, at least in part, to slower basal protein synthesis (MPS). Essential amino acids (EAA) stimulate mammalian target of rapamycin (mTORC1) signaling, acid transporter expression, and MPS are necessary for mass maintenance, but there no data on the effect inactivity this anabolic mechanism. We hypothesized that decreases older adults by blunting EAA stimulation through reduced mTORC1 signaling expression adults. Six healthy (67 ± 2 yr)...
Evidence suggests that consumption of over-the-counter cyclooxygenase (COX) inhibitors may interfere with the positive effects resistance exercise training has on reversing sarcopenia in older adults. This study examined influence acetaminophen or ibuprofen muscle mass and strength during 12 wk knee extensor progressive Thirty-six individuals were randomly assigned to one three groups consumed COX-inhibiting drugs double-blind placebo-controlled fashion: placebo (67 ± 2 yr; n = 12), (64 1...
Tendons are important for optimal muscle force transfer to bone and play a key role in functional ability. Changes tendon properties with aging could contribute declines physical function commonly associated aging. We investigated the vivo mechanical of patellar 37 men women [11 young (27 +/- 1 yr) 26 old (65 yr)] using ultrasonography magnetic resonance imaging (MRI). Patella displacement relative tibia was monitored during ramped isometric contractions knee extensors, MRI used determine...
The loss of skeletal muscle mass and strength during aging, sarcopenia, increases the risk for falls dependency. Resistance exercise (RE) training is effective at improving in older adults; however, aging associated with reduced training-induced hypertrophy. Recent research has illustrated an impaired protein synthetic response following acute bout RE adults but much less known regarding effect on breakdown (MPB). We hypothesize that ubiquitin proteasome system autophagosomal-lysosomal may...
Restriction of blood flow to a contracting muscle during low-intensity resistance exercise (BFR exercise) stimulates mTORC1 signaling and protein synthesis in human within 3 h postexercise. However, there is lack mechanistic data provide direct link between activation skeletal following BFR exercise. Therefore, the primary purpose this study was determine whether necessary for stimulating after A secondary aim describe 24-h time course response breakdown Sixteen healthy young men were...
Model systems were set up in vitro to explore the reasons why rifampin is a better sterilizing drug than isoniazid short-course chemotherapy of tuberculosis. When growth rate Mycobacterium tuberculosis strain H37Rv was reduced uniformly by lowering incubation temperature or pH culture medium, bactericidal activity and decreased similar extent. However, when maintained at 8 degrees C incubated for daily periods 1 6 h 37 C, killed more rapidly isoniazid. Maintenance control cultures without...
Amino acid transporters and mammalian target of rapamycin complex 1 (mTORC1) signaling are important contributors to muscle protein anabolism. Aging is associated with reduced mTORC1 following resistance exercise, but the role amino unknown. Young (n = 13; 28 ± 2 yr) older 68 subjects performed a bout exercise. Skeletal biopsies (vastus lateralis) were obtained at basal 3, 6, 24 h postexercise analyzed for transporter mRNA expression regulators transcription utilizing real-time PCR Western...
Recent evidence suggests aerobic exercise may help preserve soleus muscle mass during unloading. The purpose of this investigation was to examine the muscle-specific metabolic response running as it relates growth. Mixed-muscle protein synthesis [fractional synthetic rate (FSR)] and gene expression (GE) were examined in vastus lateralis (VL) (SOL) muscles from eight men (26 +/- 2 yr; Vo(2max) 63 ml.kg(-1).min(-1)) before after a 45-min level-grade treadmill run at 77 1% intensity. Muscle...
Blood flow restriction (BFR) to contracting skeletal muscle during low-intensity resistance exercise training increases strength and size in humans. However, the mechanism(s) underlying these effects are largely unknown. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) signaling protein synthesis (MPS) stimulated following an acute bout BFR exercise. The purpose this study was test hypothesis reactive hyperemia is mechanism responsible for stimulating mTORC1 MPS...
Increasing amino acid availability (via infusion or ingestion) at rest postexercise enhances transport into human skeletal muscle. It is unknown whether alterations in availability, from ingesting different dietary proteins, can enhance rates and transporter (AAT) mRNA expression. We hypothesized that the prolonged hyperaminoacidemia a blend of proteins with digestion would muscle AAT expression compared ingestion rapidly digested protein. In double-blind, randomized clinical trial, we...
Bed rest induces significant loss of leg lean mass in older adults. Systemic and tissue inflammation also accelerates skeletal muscle loss, but it is unknown whether associated to inactivity-induced atrophy healthy We determined if short-term bed increases toll-like receptor 4 (TLR4) signaling pro-inflammatory markers adult biopsy samples. Six healthy, adults underwent seven consecutive days rest. Muscle biopsies (vastus lateralis) were taken after an overnight fast before at the end Serum...
Aerobic (AE) and resistance exercise (RE) elicit unique adaptations in skeletal muscle that have distinct implications for health performance. The purpose of this study was to identify the transcriptome response acute AE RE. In a counterbalanced, crossover design, six healthy, recreationally active young men (27 ± 3 yr) completed (40 min cycling, ∼70% maximal HR) RE [8 sets, 10 reps, ∼65% 1-repetition maximum (1RM)], separated by ∼1 wk. Muscle biopsies (vastus lateralis) were obtained before...
There are conflicting reports regarding the efficacy of plant versus animal-derived protein to support muscle and strength development with resistance training. The purpose this study was determine whether soy whey supplements matched for leucine would comparably increases growth following 12 weeks Sixty-one untrained young men (n = 19) women 42) (18–35 year) enrolled in study, 48 completed trial (17 men, 31 women). All participants engaged supervised training 3×/week consumed 19 grams...
Millions of older individuals consume acetaminophen or ibuprofen daily and these same are encouraged to participate in resistance training. Several vitro studies suggest that cyclooxygenase-inhibiting drugs can alter tendon metabolism may influence adaptations Thirty-six were randomly assigned a placebo (67 ± 2 yr old), (64 1 old; 4,000 mg/day), 1,200 mg/day) group double-blind manner completed 12 wk knee extensor Before after training vivo patellar properties assessed with MRI...
Resistance exercise (RE) stimulates a muscle protein anabolic response partially through enhanced satellite cell (SC) activity, however, age- and gender-related changes in SC content over 24-h time course are not known.Ten young (27 ± 2 years) men women 11 older (70 performed an acute bout of RE. Myofiber characteristics were determined from biopsies the vastus lateralis using immunohistochemistry. Immunoblotting was used to determine phosphorylation cyclin-dependent kinase-2 expression...