A5080820950- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Valve Diseases and Treatments
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Blood disorders and treatments
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
Imperial College Healthcare NHS Trust
2020-2024
Imperial College London
2021-2024
The London College
2022
Centre for Inflammation Research
2021
St Mary's Hospital
2021
St. Mary's Hospital
2021
Hammersmith Hospital
2020
Summary Coagulation dysfunction and thrombosis are major complications in patients with coronavirus disease 2019 (COVID‐19). Patients on oral anticoagulants (OAC) prior to diagnosis of COVID‐19 may therefore have better outcomes. In this multicentre observational study 5 883 (≥18 years) admitted 26 UK hospitals between 1 April 2020 31 July 2020, overall mortality was 29·2%. Incidences thrombosis, bleeding (MB) multiorgan failure (MOF) were 5·4%, 1·7% 3·3% respectively. The presence MB, or...
The impact of COVID-19 infection on pregnant women remains relatively unknown but the physiological changes pregnancy and hypercoagulability may further increase thrombotic risk. In this retrospective multicentre observational study, we report clinical characteristics outcomes in 36 requiring hospitalisation for compared to a propensity-matched cohort non-pregnant women. Pregnant had lower haemoglobin higher lymphocyte counts no differences other haematological or biochemical parameters...
Since the onset of Covid-19 pandemic spectrum disease caused by SARS-CoV-2 has been found to be very wide with a myriad hematologic manifestations. We illustrate here peripheral blood features two patients acute kidney injury, which is part this spectrum. The images above (×100 objective) are from 15-year-old Iraqi patient β thalassemia major who was on regular transfusion and iron chelation therapy. He presented peri-cardiac arrest ventricular tachycardia injury. have suffered hemorrhage...
Vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a rare prothrombotic syndrome associated with an adenoviral vector‐based vaccine ChAdOx1 CoV‐19 (AstraZeneca, University of Oxford) or Ad26.COV2.S (Janssen; Johnson & Johnson). VITT characterized by thrombosis, often at unusual sites, particularly cerebral venous sinus thrombosis (CVST) thrombocytopenia, low fibrinogen, and significantly raised D‐dimer level.1.Scully M. Singh D. Lown R. et al.Pathologic antibodies to platelet...
Coagulation dysfunction and thrombosis are major complications in patients with coronavirus disease-19 (COVID-19). Patients on oral anticoagulants prior to diagnosis of COVID-19 may therefore have better outcomes. We aimed:To first document the frequency thrombosis, bleeding multiorgan failure (MOF) admitted contribution these 90-day mortality.To then determine effects anticoagulation, use admission same outcomes as well requirement for Intensive Care Unit (ICU) admission, when compared a...