A5020502269- Parasite Biology and Host Interactions
- Sperm and Testicular Function
- Parasites and Host Interactions
- Helminth infection and control
- Primate Behavior and Ecology
- Mollusks and Parasites Studies
- Reproductive Biology and Fertility
- Marine Ecology and Invasive Species
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Marine Invertebrate Physiology and Ecology
- Protist diversity and phylogeny
- Evolution and Genetic Dynamics
- Leech Biology and Applications
- Genomics and Phylogenetic Studies
- Bird parasitology and diseases
- Myxozoan Parasites in Aquatic Species
- Insect and Arachnid Ecology and Behavior
- Tardigrade Biology and Ecology
- Pharmacogenetics and Drug Metabolism
- Marine Biology and Ecology Research
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Protein Structure and Dynamics
- Mitochondrial Function and Pathology
Johannes Gutenberg University Mainz
2015-2024
German Primate Center
2002-2003
University of Göttingen
1997-2001
Universitätsmedizin Göttingen
1959
Based on molecular data three major clades have been recognized within Bilateria: Deuterostomia, Ecdysozoa, and Spiralia. Within Spiralia, small-sized simply organized animals such as flatworms, gastrotrichs, gnathostomulids recently grouped together Platyzoa. However, the representation of putative platyzoans was low in respective phylogenetic studies, terms both, taxon number sequence data. Furthermore, increased substitution rates platyzoan taxa raised possibility that monophyletic...
Phylogenetic analyses based on 79 ribosomal proteins of 38 metazoans, partly derived from 6 new expressed sequence tag projects for Ectoprocta, Entoprocta, Sipuncula, Annelida, and Acanthocephala, indicate the monophyly Bryozoa comprising Ectoprocta 2 taxa that have been separated more than a century seemingly profound morphological differences. Our results also show bryozoans are closely related to Neotrochozoa, including molluscs annelids, Syndermata, latter Rotifera Acanthocephala....
Abstract We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to new server and creation computational mirror, we have expanded database with addition 33 invertebrate species, including representatives 5 previously unsampled phyla, 6 mammal species. now contains entries for 21 822 genes (5160 these from species) belonging 1743 families. The inclusion species allowed us refine both evolutionary node appearance number genes/families,...
Abstract Background Although male factor accounts for 40%–50% of unintended childlessness, we are far from fully understanding the detailed causes. Usually, affected men cannot even be provided with a molecular diagnosis. Objectives We aimed at higher resolution human sperm proteome better causes infertility. were particularly interested in why reduced count decreases fertility despite many normal‐looking spermatozoa and which proteins might involved. Material methods Applying mass...
The taxon Syndermata comprises the biologically interesting wheel animals ("Rotifera": Bdelloidea + Monogononta Seisonidea) and thorny-headed worms (Acanthocephala), is central for testing superordinate phylogenetic hypotheses (Platyzoa, Gnathifera) in metazoan tree of life. Recent analyses syndermatan phylogeny suggested paraphyly Eurotatoria (free-living bdelloids monogononts) with respect to endoparasitic acanthocephalans. Data epizoic seisonids, however, were absent, which may have...
The transcription repressor FOXP2 is a crucial player in nervous system evolution and development of humans songbirds. In order to provide an additional insight into its functional role we compared target gene expression levels between human neuroblastoma cells (SH-SY5Y) stably overexpressing
We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to new server and creation computational mirror, we have expanded database with addition 33 invertebrate species, including representatives 5 previously unsampled phyla, 6 mammal species. now contains entries for 21,822 genes (5,160 these from species) belonging 1743 families. The inclusion species allowed us refine both evolutionary node appearance number genes/families, as well...
Abstract Background The metazoan taxon Syndermata comprising Rotifera (in the classical sense of Monogononta+Bdelloidea+Seisonidea) and Acanthocephala has raised several hypotheses connected to phylogeny these animal groups included subtaxa. While monophyletic origin is well established based on morphological molecular data, phylogenetic position within Spiralia, Monogononta, Bdelloidea, Seisonidea acanthocephalan sister group are still a matter debate. comparison alternative suggests that...
Thorny-headed worms (Acanthocephala) are endoparasites exploiting Mandibulata (Arthropoda) and Gnathostomata (Vertebrata). Despite their world-wide occurrence economic relevance as a pest, genome transcriptome assemblies have not been published before. However, such data might hold clues for sustainable control of acanthocephalans in animal production. For this reason, we present the first draft an acanthocephalan nuclear genome, besides mitochondrial one, using fish parasite Pomphorhynchus...
CYP3A metabolizes 50% of currently prescribed drugs and is frequently involved in clinically relevant drug interactions. The understanding roles regulations the individual genes pharmacology physiology incomplete.Using genomic sequences from 16 species we investigated evolution CYP3 loci over a period 450 million years.CYP3A amniota evolved two ancestral genes. Upon emergence eutherian mammals, one them was lost, whereas, other acquired novel environment owing to translocation. In primates,...
Abstract Molecular phylogenomics investigates evolutionary relationships based on genomic data. However, despite sequence conservation, changes in protein interactions can occur relatively rapidly and may cause strong functional diversification. To investigate such evolution, we here combine with interaction proteomics. We develop this concept by investigating the molecular evolution of shelterin complex, which protects telomeres, across 16 vertebrate species from zebrafish to humans...
Sexual selection has repeatedly been shown to be the probable driving force behind positive Darwinian evolution of genes affecting male reproductive success. Here we compare sequence sperm ligand zonadhesin with body mass dimorphism in primates. In contrast previous related studies, present approach takes into account not only catarrhine primates, but also platyrrhines and lemurs. detail, analyze concatenated fragments (555 bp) four Lemuroidea, five Platyrrhini, seven Catarrhini, using rate...
Impairment of male fertility is one the major public health issues worldwide. Nevertheless, genetic causes sub- and infertility can often only be suspected due to lack reliable easy-to-use routine tests. Yet, development a marker panel complicated by large quantity potentially predictive markers. Actually, hundreds or even thousands genes could have relevance. Thus, systematic method enabling selection most markers out many candidates required. As criterion for selection, we derived...
Acanthocephalus balkanicus Batchvarov et Combes, 1974 was incompletely described from the northern crested newt, Triturus cristatus (Laurenti) (Amphibia: Salamandridae), a possible synonym of Balkan ivanbureschi Arntzen Wielstra, pond in village Pesnopoy, southern Bulgaria. We provide full description adult males and females same taxon olm, Proteus anguinus Laurenti Proteidae), only exclusively aquatic cave-dwelling vertebrate Europe, captured Postojna-Planina Cave System Slovenia....