A5101544784- Block Copolymer Self-Assembly
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- DNA Repair Mechanisms
- Lipid Membrane Structure and Behavior
- Vibrio bacteria research studies
- Surfactants and Colloidal Systems
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Nanopore and Nanochannel Transport Studies
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Carcinogens and Genotoxicity Assessment
- Material Dynamics and Properties
- Enzyme Structure and Function
- Gene Regulatory Network Analysis
- Genomics and Chromatin Dynamics
- Aquaculture disease management and microbiota
- Microbial Metabolic Engineering and Bioproduction
- Polymer Nanocomposites and Properties
- Bacterial biofilms and quorum sensing
- Microtubule and mitosis dynamics
- Higher Education and Teaching Methods
- Rheology and Fluid Dynamics Studies
Shanghai Technical Institute of Electronics & Information
2022-2024
Huazhong University of Science and Technology
2018-2024
Tongji Hospital
2024
Wuhan Prevention and Treatment Center for Occupational Diseases
2024
Hebei Agricultural University
2024
Wenzhou University
2014-2023
Wenzhou Polytechnic
2009-2023
Ocean University of China
2004-2022
Nanjing Agricultural University
2021
Nanyang Technological University
2019
Androgen-independent metastatic prostate cancer is the main obstacle in treatment of this cancer. Unlike a majority solid cancers, usually shows poor response to chemotherapeutic drugs. In study, we have shown potential novel target, TWIST, highly conserved bHLH transcription factor, Using malignant and nonmalignant tissues, found that TWIST expression was expressed (90%) tissues but only small percentage (6.7%) benign hyperplasia. addition, levels were positively correlated with Gleason...
Id-1 (inhibitor of differentiation or DNA binding) is a helix-loop-helix protein that overexpressed in many types cancer including esophageal squamous cell carcinoma (ESCC). We previously reported ectopic expression activates the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway human cells. In this study, we confirmed positive correlation between and phospho-AKT (Ser473) expressions ESCC lines, as well on tissue microarray. To investigate significance...
Androgen-independent metastatic prostate cancer is the main cause of related death in men. One reasons for this lack understanding molecular mechanisms leading to progression cancer. In study, we have demonstrated that overexpression Id-1 (inhibitor differentiation/DNA synthesis), a member helix–loop–helix family proteins, key factor promoting angiogenesis through activation vascular endothelial growth (VEGF) cells. Using cells ectopically transfected with gene, found upregulation induced...
The antiapoptotic and epithelial-mesenchymal transition activities of Twist have been implicated in the neoplastic transformation development metastasis, respectively. Upregulation Twist, described several types human cancer, also acts as a prognostic marker poor outcome.To investigate expression oesophageal squamous cell carcinoma (SCC) its value Chinese cohort patients with SCC.Twist primary SCC 87 was investigated by immunohistochemical staining. protein level one immortalised normal...
Rev7p has been suggested to play an important role in regulating DNA damage response yeast, and recently, the human homologue (i.e., MAD2B) identified, which shares significant homology mitotic checkpoint protein MAD2. In this study, we investigated whether MAD2B played a key cellular sensitivity DNA-damaging anticancer drugs by suppressing its expression using RNA interference nasopharyngeal carcinoma cells. Using colony formation assay, found that suppression of conferred hypersensitivity...
Abstract Chromosomal instability (CIN) is a cytogenetic hallmark of human cancers. Increasing evidence suggests that impairment mitotic checkpoint causally associated with CIN. CHFR one the regulators and it delays chromosome condensation in response to stress. Epigenetic inactivation through promoter CpG hypermethylation may lead CIN has been reported several In this study, we investigated gene expression panel nasopharyngeal carcinoma (NPC), prostate, ovarian, breast cancer cell lines. We...
Abstract Epstein–Barr virus (EBV) infection is closely associated with the development of nasopharyngeal carcinoma (NPC). The EBV‐encoded RNAs (EBERs) are most abundant EBV transcripts (about 10 7 copies per cell) in infected cells. However, cellular function EBER expression, particularly epithelial cells, remains poorly understood. EBERs acquire secondary structures analogous to double‐stranded RNA (dsRNA) and may bind RNA‐dependent protein kinase (PKR) interfere its function. Activation...
Abstract Yarrowia lipolytica SWJ‐1b isolated from the marine fish gut was found to contain 47.6 g of crude protein per 100 cell dry weight and had potential use as single protein. When gene encoding enhanced green fluorescent (EGFP) inserted into surface display plasmid pINA1317‐YlCWP110 expressed in uracil mutant Y. SWJ‐1b, corresponding successfully displayed on surface, 100% yeast cells exhibited anchored target proteins. We that displaying EGFP were similar those SWJ‐1b. Furthermore, C...
MomL is a marine-derived quorum-quenching (QQ) lactonase which can degrade various N-acyl homoserine lactones (AHLs). Intentional modification of may lead to highly efficient QQ enzyme with broad application potential. In this study, we used rapid and method combining error-prone polymerase chain reaction (epPCR), high-throughput screening site-directed mutagenesis identify active mutants. way, obtained two candidate mutants, MomLI144V MomLV149A. These mutants exhibited enhanced activities...
Vibrio species are a significant causative of mass mortality in mariculture worldwide, which can quickly accumulate live food and transmit into the larval gut. With restrictions on use antibiotics aquaculture, finding proper solution to reduce risk Vibriosis is vital. This study aimed evaluate susceptibility harveyi, V. campbellii, anguillarum, parahaemolyticus twenty-six bacterial yeast strains beneficial ones enrich (Branchiopod, Artemiafranciscana, rotifer, Brachionusplicatilis copepod,...
The electric field induces the new phases and shifts phase boundaries in diagrams for diblock copolymers.