A5090920933- Cannabis and Cannabinoid Research
- Cleft Lip and Palate Research
- dental development and anomalies
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Bone health and treatments
- Orthodontics and Dentofacial Orthopedics
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Iron Metabolism and Disorders
- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
- Platelet Disorders and Treatments
- Ion Channels and Receptors
- Craniofacial Disorders and Treatments
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Blood properties and coagulation
- Bone Metabolism and Diseases
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Celiac Disease Research and Management
University of Campania "Luigi Vanvitelli"
2014-2023
San Salvatore Hospital
2023
University of Macerata
2023
Presidio Ospedaliero
2023
Istituto Nazionale di Riposo e Cura per Anziani
2023
L'organizzazione Ospedale di Civitanova M
2023
University of Milan
2007-2020
Ospedale San Paolo
2008-2019
Leonardo (United Kingdom)
2016
University of Milano-Bicocca
2016
To evaluate the dental characteristics of patients subjected to a protocol that included early secondary gingivoalveoloplasty (ESGAP).Panoramic radiographs 87 with unilateral cleft lip and palate (UCLP) 29 bilateral (BCLP) were evaluated. Missing supernumerary teeth also quantified on noncleft side in maxilla mandible. Crown root malformations tooth rotations quantified. A subsample permanent dentition was extrapolated analyze canine eruption patterns.A total 48.8% UCLP presented missing...
The pathogenesis of bone resorption in β-thalassemia major is multifactorial and our understanding the underlying molecular cellular mechanisms remains incomplete. Considering emerging importance endocannabinoid/endovanilloid system metabolism, it may be instructive to examine a potential role for this development osteoporosis patients with its relationship iron overload chelation therapy. This study demonstrates that, thalassemic-derived osteoclasts, tartrate-resistant acid phosphatase...
Abstract Context: Obesity is associated with a low-grade inflammatory state and adipocyte (ADP) hyperplasia/hypertrophy. inhibits the “browning” of white adipose tissue. Cannabinoid receptor 2 (CB2) agonists reduce food intake induce antiobesity effect in mice. A common missense CB2 variant, Q63R, causes CB2-reduced function. Objective: To evaluate influence on modulation childhood obesity ADP activity morphology. Design: CB2-Q63R variant was analyzed obese Italian children. The effects an...
Celiac Disease (CD) represents an autoimmune disorder triggered by the exposure to gluten in genetically susceptible individuals. Recent studies suggest involvement of macrophages CD pathogenesis. Macrophages are immune cells, present as pro-inflammatory classically activated (M1) or anti-inflammatory alternatively (M2). The Cannabinoid Receptor 2 (CB2) has important and immunoregulatory properties. We previously demonstrated that a common CB2 functional variant, Q63R, causing reduced...
Tumor-associated macrophages and their alternative activation states together with cytokines growth factors trapped in tumor microenvironment contribute to the progression of OS. In contrast other types, M2 polarized macrophages, reduce metastasis improve survival osteosarcoma patients. Mifamurtide is an immunomodulatory drug given standard adjuvant chemotherapy high-grade outcome. Macrophages obtained from peripheral blood mononucleated cells healthy donors MG63 were cultured alone...
Osteoporosis is a condition characterized by decrease in bone density, which decreases its strength and results fragile bones. The endocannabinoid/endovanilloid system has been shown to be involved the regulation of skeletal remodelling. aim this study was investigate possible modulation mass mediated transient receptor potential vanilloid type 1 channel (TRPV1) vivo vitro.A multidisciplinary approach, including biomolecular, biochemical morphological analysis, used involvement TRPV1 changes...
Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibodies-mediated platelet destruction, a prevalence of M1 pro-inflammatory macrophage phenotype and elevated T helper 1 2 lymphocytes (Th1/Th2) ratio, resulting in impairment inflammatory profile immune response. Macrophages are cells, present as classically activated macrophages (M1) or anti-inflammatory alternatively (M2). They have key role ITP, acting both effector phagocytizing platelets, and, antigen...
Background: The Milan surgical protocol includes the use of an early secondary gingivoalveoloplasty together with hard palate closure at 18 to 36 months, avoid later bone grafting. goal this study was evaluate long-term quality ossification in patients who have undergone gingivoalveoloplasty. Methods: samples consisted panoramic radiographs 87 unilateral cleft lip–cleft and 29 bilateral patients. records available allowed for a longitudinal cross-sectional evaluation area. Alveolar bridging...
No consensus exists about the causes of restriction maxillary growth in patients with cleft lip and palate (CLP). The aim this study was to try identify impairment other than influence surgical technique skill. We analysed a sample 129 consecutively treated 5-year-old children unilateral (UCLP), who were operated on by same surgeon protocol. Multiple cephalometric measurements showed wide distribution values for growth. selected SNA as value describing position. Variables investigated were:...
Chronic blood transfusions are responsible to cause iron overload, which leads several complications end organs and osteoporosis. Iron chelation is needed remove excess contain bone-mass loss. Deferasirox the most recent oral chelator that prevents transfusion related overload complications. Recently Eltrombopag (ELT) chelating properties emerging. ELT an agonist at Thrombopoietin receptor, used in treatment of thrombocytopenia. We tested overloaded osteoclasts from thalassemic patients...
We conducted a case-control association analysis to establish the role of common CB2 functional variant, Q63R, in susceptibility inflammatory bowel disease (IBD).Endocannabinoids may limit intestinal inflammation through cannabinoid receptor 1 and/or 2 (CB1, CB2).We genotyped 217 pediatric IBD patients [112 Crohn's (CD), 105 ulcerative colitis (UC)] and 600 controls for CB2-Q63R variant by Taqman assay. Data were collected from clinical records on age at diagnosis, activity, duration...
Duchenne Muscular Dystrophy (DMD) is a very severe X-linked dystrophinopathy. It due to mutation in the DMD gene and causes muscular degeneration conjunction with several secondary co-morbidities, such cardiomyopathy respiratory failure. characterized by chronic inflammatory state, corticosteroids represent main therapy for these patients. To contradict drug-related side effects, there need novel more safe therapeutic strategies. Macrophages are immune cells stringently involved both...
// Francesca Punzo 1, 2 , Iolanda Manzo Chiara Tortora Elvira Pota 1 Velia D' Angelo Giulia Bellini Alessandra Di Paola Federica Verace Fiorina Casale and Rossi Department of Women, Child General Specialist Surgery, University Campania "Luigi Vanvitelli", Naples 80138, Italy Experimental Medicine, Division Pharmacology "Leonardo Donatelli", Correspondence to: Rossi, email: francesca.rossi@unicampania.it Keywords: oncogene; MYB; SKI; transcriptional regulation; acute myeloid leukemia...