A5041406379- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Child Development and Digital Technology
- Language Development and Disorders
- Attention Deficit Hyperactivity Disorder
- Reading and Literacy Development
- Obsessive-Compulsive Spectrum Disorders
- Family and Disability Support Research
- Medical Image Segmentation Techniques
- Domain Adaptation and Few-Shot Learning
- Functional Brain Connectivity Studies
- Behavioral and Psychological Studies
- Child and Animal Learning Development
- Neuroscience and Music Perception
- Image Retrieval and Classification Techniques
- Genomic variations and chromosomal abnormalities
- Hearing Loss and Rehabilitation
- Blind Source Separation Techniques
- Phonetics and Phonology Research
- AI in cancer detection
- Animal Vocal Communication and Behavior
- Linguistics and Discourse Analysis
- Cognitive Abilities and Testing
- Sparse and Compressive Sensing Techniques
- Child Nutrition and Feeding Issues
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2012-2024
Cognitive Neuroimaging Lab
2016-2024
CEA Paris-Saclay
2012-2024
Inserm
2012-2024
Centre National de la Recherche Scientifique
2024
Université Paris-Saclay
2024
Karolinska Institutet
2017-2022
Stockholm County Council
2017-2021
Stockholm Health Care Services
2018-2020
Laboratoire de Sciences Cognitives et Psycholinguistique
2013
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated differences between autistic individuals (n
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects social communication skills and flexible behaviour. Developing new treatment approaches for ASD requires early identification of the factors influence later behavioural outcomes. One fruitful research paradigm has been prospective study infants with first degree relative ASD, who have around 20% likelihood developing themselves. Early findings identified range candidate neurocognitive markers such as delayed...
Alterations in social cognition (SC) are hypothesized to underlie communication and interaction challenges autism spectrum disorder (ASD). The aetiological underpinnings driving this association remain unclear. We examined SC 196 twins with ASD, other neurodevelopmental disorders or typical development using the naturalistic Movie for Assessment of Social Cognition. Autism its severity were assessed Diagnostic Observation Schedule-2, autistic traits Responsiveness Scale-2. Using within...
Autism spectrum disorder (ASD) has been found to be associated with alterations in resting state (RS) functional connectivity, including areas forming the default mode network (DMN) and salience (SN). However, insufficient control for confounding genetic environmental influences other methodological issues limit generalizability of previous findings. Moreover, it hypothesized that ASD might marked by early hyper-connectivity followed later hypo-connectivity. To date, only a few studies have...
Females might possess protective mechanisms regarding autism spectrum disorder (ASD) and require a higher detrimental load, including structural brain alterations, before developing clinically relevant levels of autistic traits. This study examines sex differences in morphology traits using within-twin pair approach. Twin design inherently controls for shared confounders enables the gene-independent neuroanatomical variation. N = 148 twins (62 females) from 49 monozygotic 25 dizygotic...
Abstract Background Females with autism spectrum disorder have been reported to exhibit fewer and less severe restricted repetitive behaviors interests compared males. This difference might indicate sex-specific alterations of brain networks involved in symptom domains, especially within cortico-striatal sensory integration networks. study used a well-controlled twin design examine sex differences anatomy relation behaviors. Methods In 75 pairs ( n = 150, 62 females, 88 males) enriched for...
Abstract In this experiment using the conditioned head-turn procedure, 18-month-old French-learning toddlers were trained to respond either a target noun ("la balle"/the ball) or verb ("je mange"/I eat). They then tested on word recognition in two syntactic contexts: was preceded by correct function ("une balle"/a ball "on mange"/they eat), an incorrect word, signaling from other category (*"on balle"/they *"une mange"/a We showed that 18-month-olds exploit context on-line recognize word:...
Background Autism Spectrum Disorder ( ASD ) is associated with altered global and local visual processing. However, the nature of these alterations remains controversial, contradictory findings notions ranging from a reduced drive to integrate information into coherent ‘gestalt’ (“ weak central coherence ” = WCC an enhanced perceptual functioning EPF in Methods This study assessed association between autism global/local processing, using large sample monozygotic MZ dizygotic DZ twins N 290,...
Abstract A female advantage in social cognition (SoC) might contribute to women’s underrepresentation autism spectrum disorder (ASD). The latter could be underpinned by sex differences brain structure. This study investigated the relationship between structural networks and SoC females males relation ASD autistic traits twins. We used a co-twin design 77 twin pairs (39 female) aged 12.5 31.0 years. Twin were discordant or concordant for traits, other neurodevelopmental disorders neurotypical...
Early intensive behavioral intervention (EIBI) is widely applied in young children with autism spectrum disorder. Little research has addressed the significance of adherence to EIBI practices for treatment outcomes. The York Measure Quality Intensive Behavioral Intervention (YMQI) was designed assess quality delivery Ontario, Canada. objective this study examine cross-cultural validity YMQI a clinical Swedish community sample 30 boys and four girls aged 2.5 6 years. Internal consistency...
Abstract Females with autism spectrum disorder have been reported to exhibit fewer and less severe restricted repetitive behaviors interests compared males. This difference might indicate sex specific alterations of brain networks involved in symptom domains, especially within cortico-striatal sensory integration networks. study used a well-controlled twin design examine differences anatomy relation behaviors. In 75 pairs (n=150, 62 females, 88 males) enriched for (n=32), other...
Inferring the functional specificity of brain regions from Magnetic Resonance Images (fMRI) data is a challenging statistical problem. While General Linear Model (GLM) remains standard approach for mapping, supervised learning techniques (a.k.a. decoding) have proven to be useful capture multivariate effects distributed across voxels and regions. Up now, much effort has been made improve decoding by incorporating prior knowledge in form particular regularization term. In this paper we...
Abstract A central feature in music is the hierarchical organization of its components. Musical pieces are not a simple concatenation chords, but characterized by rhythmic and harmonic structures. Here, we explore if sensitivity to structure might emerge absence any experience with musical stimuli. For this, tested rats detect difference between structured unstructured excerpts compared their performance that humans. Structured melodies were Mozart's sonatas. Unstructured created...
Abstract While previous research has investigated neuroradiological findings in autism spectrum disorder (ASD) and attention-deficit hyperactivity (ADHD), the entire range of neurodevelopmental disorders (NDDs) not yet been well-studied using magnetic resonance imaging (MRI). Considering overlap among NDDs simultaneous development brain face, guided by molecular signaling, we examined relationship actionable incidental (non-actionable) MRI NDD diagnoses together with facial morphological...
Abstract Four‐and‐a‐half‐month‐olds look longer at silent mouth movements corresponding to a language they previously listened to. The perceptual narrowing hypothesis suggests this general ability decline as consequence of experience with the infant's native language. We tracked eye‐gaze German and Swedish infants longitudinally in an intersensory matching procedure 4.5 6 months age. Infants watched sequentially side‐by‐side presentations visual auditory fluent speech their respective or...
Methods to enhance the quality of delivered Early Intensive Behavioral Intervention (EIBI) for children with autism spectrum disorder (ASD) have received surprisingly little attention in previous research. In a pragmatic randomized controlled pilot study, we studied feasibility and effects enriched supervision (using detailed video feedback) on EIBI compared regular only, over period 4–6 months. was conducted 30 ASD by preschool staff, where 18 enriched, 12 supervisions. evaluated using York...