A5011167997- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Family and Disability Support Research
- Neural and Behavioral Psychology Studies
- Child Nutrition and Feeding Issues
- Face Recognition and Perception
- Child and Animal Learning Development
- Evolutionary Psychology and Human Behavior
- Fetal and Pediatric Neurological Disorders
- Virology and Viral Diseases
- Primate Behavior and Ecology
- Child Development and Digital Technology
- Retinal Development and Disorders
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Cerebral Palsy and Movement Disorders
- Cognitive Abilities and Testing
- Body Image and Dysmorphia Studies
- Gaze Tracking and Assistive Technology
- Functional Brain Connectivity Studies
- Cognitive Science and Mapping
- Language Development and Disorders
- Neonatal and fetal brain pathology
University Hospital Frankfurt
2019-2025
Goethe University Frankfurt
2017-2025
University Hospital Heidelberg
2017-2023
Central Institute of Mental Health
2017-2023
Heidelberg University
2017-2023
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated differences between autistic individuals (n
Background Reward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding specificity atypicalities for reward in ASD. Aims Utilising a large sample, we aimed assess response type (social, monetary) and phase (anticipation, delivery) Method Functional magnetic resonance imaging during monetary anticipation delivery was performed 212 individuals with ASD (7.6–30.6...
Objective: Autism spectrum disorder (ASD) is accompanied by highly individualized neuroanatomical deviations that potentially map onto distinct genotypes and clinical phenotypes. This study aimed to link differences in brain anatomy specific biological pathways pave the way toward targeted therapeutic interventions. Methods: The authors examined neurodevelopmental cortical thickness their genomic underpinnings a large clinically diverse sample of 360 individuals with ASD 279 typically...
ABSTRACT Mannerisms describe repetitive or unconventional body movements like arm flapping. These are early markers of restricted and behaviors (RRBs) in autism spectrum disorder (ASD). However, assessing mannerisms reliably is challenging. Even after extensive training behavioral observations, inter‐rater agreements for mannerism items remain insufficient. The current study used machine learning (ML) to classify from videotaped observations children with ASD. We developed a classification...
ABSTRACT Autism is often linked to attenuated social attention, including a lowered looking preference for biological motion in autistic compared non‐autistic children. This has been suggested as an autism marker childhood. However, few studies have investigated whether this bias persists into adulthood. Furthermore, the underlying cognitive mechanism of group difference largely unknown. Pupillary responses established index salience processing and are thus promising measurement bases...
Background Previous research demonstrated atypical attention in children with attention‐deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets ASD, processing of alerting cues ADHD. The locus coeruleus‐norepinephrine (LC‐NE) system plays an important role exploiting increase task performance. present study’s aim was examine subcortical processes underlying ASD...
Background Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual understudied, whereas restricted viewing suggested saccade dysmetria ASD altered pontocerebellar motor modulation. Methods Oculomotor was recorded using remote eye tracking 142 participants and matched neurotypical controls free of naturalistic videos with without human content. sample heterogenous concerning age (6–30 years),...
Abstract Background Autism spectrum disorders (ASD) are neurodevelopmental conditions accompanied by differences in brain development. Neuroanatomical autism variable across individuals and likely underpin distinct clinical phenotypes. To parse heterogeneity, it is essential to establish how the neurobiology of ASD modulated associated with co-occurring conditions, such as attention-deficit/hyperactivity disorder (ADHD). This study aimed (1) investigate between-group autistic without ADHD,...
Abstract Previous work has shown divergent pupil dilation (PD) and gaze behavior in individuals with autism spectrum disorder (ASD), which may relate to the development of social difficulties early life. Here, we investigated temporal dynamics both phenotypes during naturalistic videos a person displaying facial emotion expressions 61 autistic non-autistic preschoolers. PD was segmented into three serial time components derived from principal component analysis. Growth curve analysis applied...
Abstract Reactive joint attention (RJA) describes shared on a cued target. This key ability is attenuated in autistic compared to non-autistic preschoolers with low cognitive ability, and thus trained during early intervention. We evaluated the development of RJA matched within randomized controlled trial naturalistic developmental behavioral intervention A-FFIP (intervention [ n = 32] versus intervention-as-usual [EIAU, 28]), which further ( 52). A screen-based eye-tracking paradigm...
Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe the Movie for Assessment Social Cognition (MASC) test n = 23 adolescents with Autism Spectrum Disorder (ASD) and 24 age, IQ sex‐matched neurotypical controls (NTC). The MASC consists 43 video sequences depicting human interactions, each followed by multiple‐choice question concerning...
Abstract Attenuated social attention has been described as a reduced preference for compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus‐norpinephrine (LC‐NE) system modulates sensory reactivity and is promising underlying mechanism. LC‐NE activity indexed by stimulus‐evoked pupillary response (SEPR) partially luminance‐adaptation (LAPR), which were both shown be aberrant ASD. We examined whether SEPR LAPR explain an attenuated preference....
Abstract Background Naturalistic developmental behavioural interventions (NDBI) have been shown to improve autism-specific symptoms in young children with Autism Spectrum Disorder (ASD). NDBI approaches, such as the ASD-specific Frankfurt Early Intervention Programme for ASD (A-FFIP), are based on and learning aspects. A-FFIP is a low-intensity intervention which can easily be implemented local health care/social welfare system. The aim of present study establish 1-year efficacy manualised...
Abstract Background Attenuated social attention is a key marker of autism spectrum disorder (ASD). Recent neuroimaging findings also emphasize an altered processing sensory salience in ASD. The locus coeruleus–norepinephrine system (LC-NE) has been established as modulator this (SSP). We tested the hypothesis that LC-NE functioning contributes to different SSP and results diverging Methods analyzed baseline eye-tracking data EU-AIMS Longitudinal European Autism Project (LEAP) for subgroups...
Empirical evidence suggests a great positive association between measures of fluid intelligence and working memory capacity, which implied to some researchers that is little more than memory. Because this conclusion mostly based on correlation analysis, causal relationship has not yet been established. The aim the present study was therefore provide an experimental analysis relationship. In first study, 60 participants worked items Advanced Progressive Matrices (APM) while simultaneously...
Abstract Background The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a pressing need for large definitive studies to delineate the nature extent of key case/control differences direct research towards fruitful areas future investigation. Here we focus on perception biological motion, promising index social brain function which may...
Abstract Background Reward processing has been proposed to underpin atypical social behavior, a core feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding the specificity atypicalities for rewards in ASD. Utilizing large sample, we aimed assess altered reward response type (social, monetary) and phase (anticipation, delivery) Methods Functional magnetic resonance imaging during monetary anticipation delivery was...
The Children's Communication Checklist‐2 (CCC‐2) is often applied to assess pragmatic language impairment which highly prevalent in autism spectrum disorder (ASD) and several mental health conditions. We replicated previous findings on the limited applicability of CCC‐2 clinical samples inconsistent concerning factor structure. aim present study was, thus, develop a concise, simplified, revised version large German‐speaking sample. Four groups children adolescents aged 4 17 years were...
Autism Spectrum Disorder (ASD) is a group of neurodevelopmental conditions associated with quantitative differences in cortical and subcortical brain morphometry. Qualitative assessment morphology provides complementary information on the possible underlying neurobiology. Studies neuroradiological findings ASD have rendered mixed results, await robust replication sizable independent sample. We systematically comprehensively assessed large cohort participants age-matched controls (total...
Face-processing timing differences may underlie visual social attention between autistic and non-autistic people, males females. This study investigates the of effects neurotype sex on face-processing, their dependence age. We analysed EEG data during upright inverted photographs faces from 492 participants Longitudinal European Autism Project (141 neurotypical males, 76 females, 202 73 females; age 6-30 years). detected timings sex/diagnosis event-related potential amplitudes at...