A5058248091- Advanced Wireless Communication Techniques
- Wireless Communication Networks Research
- Neuroendocrine regulation and behavior
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
- Stress Responses and Cortisol
- Synthesis and Reactivity of Sulfur-Containing Compounds
- PAPR reduction in OFDM
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Synthesis and Catalytic Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Neuroscience of respiration and sleep
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Circadian rhythm and melatonin
- Ultra-Wideband Communications Technology
- Sulfur-Based Synthesis Techniques
- Mental Health Research Topics
- Power Line Communications and Noise
- Mind wandering and attention
- Advanced Adaptive Filtering Techniques
- Neuropeptides and Animal Physiology
- Problem Solving Skills Development
- Full-Duplex Wireless Communications
University of Occupational and Environmental Health Japan
2017-2024
Steadman Philippon Research Institute
2024
Tokyo Medical and Dental University
2022-2023
Suzuki (Japan)
2022-2023
University of Tsukuba
2001-2022
Kyushu University
2021
National Institutes for Quantum Science and Technology
2019-2021
Ohara Memorial Institute for Science of Labour
2021
Japan Society for the Promotion of Science
2017
Keio University
2007-2013
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+-)-vindorosineG. Buechi, Kent E. Matsumoto, and Haruki NishimuraCite this: J. Am. Chem. Soc. 1971, 93, 13, 3299–3301Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/ja00742a042https://doi.org/10.1021/ja00742a042research-articleACS PublicationsRequest reuse permissionsArticle Views1324Altmetric-Citations130LEARN ABOUT THESE...
Several 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives were synthesized from 3-(bromomethyl)-1,2-benzisoxazole by the reaction with sodium bisulfite followed chlorination and amination. Some of them displayed marked anticonvulsant activity in mice. The introduction a halogen atom to 5 position benzisoxazole ring caused increased neurotoxicity; substitution sulfamoyl group decreased activity. monoalkylated compounds might be result biotransformation. Among these compounds, (1a) was thought...
The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of chloro and cyano groups at was accomplished by Sandmeyer reaction 6-amino-1,8-naphthyridine derivatives 9 via their 6-diazonium salts. extended to synthesis 6-fluoro analogues, involving Balz-Schiemann diazonium tetrafluoroborate. Furthermore, a series 1-ethyl, 1-vinyl, 1-(2-fluoroethyl), 1-(difluoromethyl) analogues 7-substituted...
Abstract Oxytocin is involved in pain transmission, although the detailed mechanism not fully understood. Here, we generate a transgenic rat line that expresses human muscarinic acetylcholine receptors (hM3Dq) and mCherry oxytocin neurons. We report clozapine-N-oxide (CNO) treatment of our oxytocin-hM3Dq-mCherry rats exclusively activates neurons within supraoptic paraventricular nuclei, leading to activation locus coeruleus (LC) dorsal raphe nucleus (DR), differential gene expression...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b,f]oxepinacetic acids and related compoundsYasutaka Nagai, Akira Irie, Hideo Nakamura, Katsuhiko Hino, Hitoshi Uno, Haruki NishimuraCite this: J. Med. Chem. 1982, 25, 9, 1065–1070Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://doi.org/10.1021/jm00351a012RIGHTS & PERMISSIONSArticle...
Abstract Various studies contributed to discover novel mechanisms of central arginine vasopressin (AVP) system responsible for the behaviour albeit endogenous activation. We established a transgenic rat line which expresses both human muscarinic acetylcholine receptors (hM3Dq), ligand is clozapine-N-oxide (CNO), and mCherry fluorescence specifically in AVP neurons. The neurons that indicate expression hM3Dq gene were observed suprachiasmatic (SCN), supraoptic (SON), paraventricular nuclei...
In order to examine how rumination and social problem solving intensify depression, the present study investigated longitudinal associations among each dimension of evaluated aspects these constructs that predicted subsequent depression. A three-wave study, with an interval 4 weeks between waves, was conducted. Japanese university students completed Beck Depression Inventory-Second Edition, Ruminative Responses Scale, Social Problem-Solving Inventory-Revised Short Version, Interpersonal...
Background: There is a dearth of knowledge regarding the correlation between femoroacetabular impingement (FAI) and osteitis pubis (OP) among symptomatic soccer players. Purpose: To elucidate whether arthroscopic FAI correction effective for young competitive players with combined OP or perisymphyseal pubic bone marrow edema (BME). Study Design: Case series; Level evidence, 4. Methods: A total 577 consecutive patients who underwent were retrospectively reviewed minimum 2-year follow-up....
3-Amidinomethyl- (8), 3-imidazolinylmethyl- (9) and 3-tetrahydropyrimidinylmethyl-1, 2-benzisoxazole (10) were synthesized from 1, 2-benzisoxazole-3-acetonitrile (4) via iminoether (7). 3-Tetrazolylmethyl-1, (5) 2-benzisoxazole-3-acetamide oxime (11) also prepared 4. 3-Aminoethyl-1, (25), a tryptamine analogue of 2-benzisoxazole, was 3-chloroethyl-1, (20). The bromination 2-benzisoxazole-3-acetic acid (1) with one molar equivalent bromine afforded α-bromo-1, (27), which decarboxylated to...
Abstract Fluorination of the 2,6‐disubstituted 3‐aminopyridines 5 and 12 by Balz‐Schiemann reaction is described. 2,6‐Dichloro‐3‐pyridinediazonium tetrafluoroborate ( 6 ) 2‐substituted 6‐acetylamino‐3‐pyridinediazonium tetrafluoroborates 13 were heated with or without a solvent to give corresponding fluorinated pyridines 7 14 , respectively, in good yields. 2‐Substituted 6‐acetylamino‐3‐fluoropyridines converted known method into series 7‐substituted...
This study examined possible associations between rumination and impulsivity if these variables make unique contributions to increasing depression. A three-wave longitudinal was conducted with an interval of four weeks waves. University students in five Japanese universities completed the version Beck Depression Inventory-Second Edition, Ruminative Responses Scale, UPPS-P Impulsive Behavior Scale on three occasions (Time 1, n = 284, Mean age 20.07 years, SD 2.50, Age range 18–43 years; Time...
This study examined the relationship between trait rumination and effectiveness of problem solving strategies as assessed by Means-Ends Problem-Solving Test (MEPS) in a nonclinical population. The present extended previous studies terms using two instructions MEPS: second-person, actual strategy instructions, which has been utilized on rumination, third-person, ideal-strategy is considered more suitable for assessing strategies. We also replicated association each dimension Social...
Various types of acute/chronic nociceptive stimuli cause neuroendocrine responses such as activation the hypothalamo-neurohypophysial (oxytocin [OXT] and arginine vasopressin [AVP]) system hypothalamo-pituitary adrenal (HPA) axis. Chronic multiple-arthritis activates OXT/AVP system, but effects acute mono-arthritis on in same animals has not been simultaneously evaluated. Further, AVP, corticotropin-releasing hormone (CRH), predominantly HPA axis chronic multiple-arthritis, participation AVP...
Racemates and enantiomers of 1-substituted 4-[2-(3-hydroxyphenyl)-1-phenylethyl]piperazine derivatives (3-18) were synthesized, their analgesic other pharmacological activities structure-activity relationships investigated. The S-(+) 2a, 5, 7, 9, 10, 15-18 had a stronger activity than R-(-) enantiomers; the strongest one [(S)-(+)-10] was 105 times as potent that morphine. these compounds opposite configuration to morphine with respect its (C-9) asymmetric center but same tyrosine residue...
A new isoflavone, 6, 4'-dihydroxy-7-methoxy-isoflavone, was isolated from Chinese Pueraria flowers.
The main purpose of this study was to examine whether depressive rumination and social problem solving are prospectively associated with symptoms. Nonclinical university students (N = 161, 64 men, 97 women; M age 19.7 yr., SD 3.6, range 18-61) recruited from three universities in Japan completed the Beck Depression Inventory-Second Edition (BDI-II), Ruminative Responses Scale, Social Problem-Solving Inventory-Revised Short Version (SPSI-R:S), Means-Ends Procedure at baseline, BDI-II again 6...
Abstract The median eminence (ME) anatomically consists of external (eME) and internal (iME) layers. hypothalamic neurosecretory cells terminate their axons in the eME secrete neurohormones regulating anterior pituitary hormone secretion involved stress responses into portal vein located eME. Magnocellular (MNCs) which produce arginine vasopressin (AVP) oxytocin paraventricular (PVN) supraoptic nuclei (SON) posterior gland (PP) through iME. Here, we provide first evidence that oestrogen...
Calcium balance is important in bone homeostasis. The transient receptor potential vanilloid (TRPV) channel a nonselective cation permeable to calcium and activated by various physiological pharmacological stimuli. TRPV1 TRPV4, particular, have roles intracellular Ca2+ signaling extracellular homeostasis cells. TRPV4 separately mediate osteoclast osteoblast differentiation, deficiency any of these channels leads increased mass. However, it remains unknown whether mass increases the absence...
Previous research on the relationship between rumination and behavioral impulsivity has been limited because was assessed by using individual tasks. This study examined concurrent associations of a latent variable named impulsive action with depression to alleviate task-impurity problem low reliability laboratory tasks assessing impulsivity. also whether stressors mediated association rumination. University students in Japan (N = 176) conducted three action: Go/No-Go Task, Stop Signal...
Abstract Oxytocin (OXT) is produced in the hypothalamic nuclei and secreted into systemic circulation from posterior pituitary gland. In central nervous system, OXT regulates behaviours including maternal feeding behaviours. Our aim to evaluate whether oestrogen dynamics. Herein, we provide first evidence that dynamics hypothalamus vary with sex may modulate dynamic changes levels, using OXT-mRFP1 transgenic rats. The fluorescence intensity of expression mRFP1 genes highest during oestrus...