A5007758356- Cellular Mechanics and Interactions
- Advanced Thermodynamics and Statistical Mechanics
- Cell Adhesion Molecules Research
- Muscle Physiology and Disorders
- Force Microscopy Techniques and Applications
- 3D Printing in Biomedical Research
- Mechanical and Optical Resonators
- Orbital Angular Momentum in Optics
- Lipid Membrane Structure and Behavior
- Microfluidic and Bio-sensing Technologies
- Neural dynamics and brain function
- stochastic dynamics and bifurcation
- Blood properties and coagulation
- Biocrusts and Microbial Ecology
- Advanced Fluorescence Microscopy Techniques
- Digital Holography and Microscopy
- Neural Networks and Applications
- Protein Structure and Dynamics
- Neuroscience and Neural Engineering
- Reproductive Biology and Fertility
- Cardiomyopathy and Myosin Studies
- Congenital limb and hand anomalies
- Cold Atom Physics and Bose-Einstein Condensates
- Material Dynamics and Properties
University of Göttingen
2022-2024
Czech Academy of Sciences, Institute of Physics
2021-2024
Multiscale Bioimaging
2024
University of Münster
2020-2021
Institute of Cell Biology
2021
Abstract Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation objects, ranging from atoms to space sails. Since the pioneering work by Arthur Ashkin in 1970s, optical have evolved into sophisticated instruments been employed a broad range applications life sciences, physics, engineering. These include accurate force torque measurement at femtonewton level, microrheology complex fluids, single micro- nano-particle spectroscopy, single-cell...
Intracellular organization is a highly regulated homeostatic state maintained to ensure eukaryotic cells' correct and efficient functioning. Thanks decades of research, vast knowledge the proteins involved in intracellular transport has been acquired. However, how these influence potentially regulate mechanical properties cell largely unknown. There deep gap between understanding cortical mechanics, which accessible by series experimental tools, situation that neglected due difficulty...
Tension and mechanical properties of muscle tissue are tightly related to proper skeletal function, which makes experimental access the biomechanics formation a key requirement advance our understanding function development. Recently developed elastic in vitro culture chambers allow for raising 3D under controlled conditions measure global force generation. However, these inherently incompatible with high-resolution microscopy limiting their usability measurements, preventing exploitation...
Active microrheology is one of the main methods to determine mechanical properties cells and tissue, modelling these viscoelastic under heavy debate with many competing approaches. Most experimental active such as optical tweezers or atomic force microscopy based approaches rely on single cell measurements, thus suffer from a low throughput. Here, we present novel method for frequency-dependent using acoustic forces which allows multiplexed measurements several in parallel. Acoustic...
The mechanical properties of the cytoplasm and nucleoplasm are crucial for correct robust functioning a cell play key role in understanding how signals transferred to nucleus. Here, we demonstrate remarkable shape mimicry between cellular nuclear oocytes, following externally applied deformation without direct contact cortex This effect arises from surprisingly soft fluid-like that is barely resisting any external strain, while viscoelastic drives transmission. Comparative studies jellyfish,...
We derive a bound for entropy production in terms of the mean normalizable path-antisymmetric observables. The optimal observable this is shown to be signum production, which often easier determined or estimated than itself. It can preserved under coarse graining by use simple path grouping algorithm. demonstrate relation and its properties using driven network on ring, saturates short times any driving strength. This work open way systematic production.
Living cells are complex entities that perform many different tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics guide and support function. This in stark contrast expected functional role properties should have for core cellular functions such as organization, homeostasis transport. From a point view, viscoelastic materials...
Abstract Understanding life is arguably among the most complex scientific problems faced in modern research. From a physics perspective, living systems are dynamic entities that operate far from thermodynamic equilibrium. 1–3 This active, non-equilibrium behaviour, with its constant hunger for energy, allows to overcome ever dispersing forces of entropy, and drives cellular organisation. 4, 5 Unfortunately, analysis methods provided by toolbox statistical mechanics cannot be used such...
Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation objects ranging from atoms to space sails. Since the pioneering work by Arthur Ashkin in 1970s, optical have evolved into sophisticated instruments been employed a broad range applications life sciences, physics, engineering. These include accurate force torque measurement at femtonewton level, microrheology complex fluids, single micro- nanoparticle spectroscopy, single-cell analysis,...
Abstract Living cells are complex entities that perform many different tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics guide and support function. This in stark contrast expected functional role properties should have for core cellular functions such as organization, homeostasis transport. From a point view, viscoelastic...
Living cells are complex entities that perform many different tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics guide and support function. This in stark contrast expected functional role properties should have for core cellular functions such as organization, homeostasis transport. From a point view, viscoelastic materials...
Abstract The mechanical properties and tension of muscle tissue are tightly related to proper skeletal function, which makes experimental access the biomechanics development a key requirement advance our understanding function development. Recently developed elastic in vitro culture chambers allow for raising 3D under controlled conditions measurements force generation. However, these inherently incompatible with high resolution microscopy limiting their usability global measurements,...
We derive a bound for entropy production in terms of the mean normalizable path-antisymmetric observables. The optimal observable this is shown to be signum production, which often easier determined or estimated than itself. It can preserved under coarse graining by use simple path grouping algorithm. demonstrate relation and its properties using driven network on ring, saturates short times any driving strength. This work open way systematic production.
Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited disease, where increasing muscle weakness leads to loss of ambulation and premature death. DMD is caused by mutations in dystrophin gene, known reduce contractile capacity tissue both vivo , also reconstituted systems vitro . However, these observations result from mechanical studies that focused on stimulated contractions skeletal tissues. Seemingly paradoxical, upon evaluating bioengineered muscles produced...