A5030688551- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Blood transfusion and management
- Blood disorders and treatments
- Hepatitis B Virus Studies
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Neonatal Health and Biochemistry
- Blood donation and transfusion practices
- Protein purification and stability
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Blood properties and coagulation
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Mycobacterium research and diagnosis
- Systemic Lupus Erythematosus Research
- Pancreatic function and diabetes
- Salivary Gland Disorders and Functions
Kent State University
2023-2024
College of Wooster
2023-2024
University of Akron
2019-2024
Institut National de la Transfusion Sanguine
1981-2015
Medical Research Council
1991
Inserm
1978-1990
Sorbonne Université
1960-1987
Marie Curie
1987
Hôpital Rothschild
1986
Hôpital Saint-Antoine
1960-1985
cDNA clones encoding a human blood group Rh polypeptide were isolated from bone marrow library by using polymerase chain reaction-amplified DNA fragment the known common N-terminal region of proteins. The entire primary structure has been deduced nucleotide sequence 1384-base-pair-long clone. Translation open reading frame indicates that protein is composed 417 amino acids, including initiator methionine, which removed in mature protein, lacks cleavable sequence, and no consensus site for...
Nine cases of acquired B antigen were studied. By quantitative methods the variation A reactivity and number sites was found to be inversely related reactivity. agglutination kinetics using an immune anti-B, reactive structure differ from that a normal B. Agglutination variation, with pH, points out part played by one electrically charged chemical group. No transferase galactosyl activity in serum, no substance plasma. According these results must have been formed at expense structure. This...
The study of the alpha-N-acetylgalactosaminyltransferase in sera 19 individuals belonging to rare Am blood group makes it possible confirm heterogeneity this phenotype established on genetical and immunological criteria. Two groups subjects, Ay, can be distinguished. For first group, named Am, 15 samples (7 families) have been studied, is inherited as an allele at ABO locus. 14 these whose kinetic properties were similar those A1 subjects. In one family, however, A transferase detected type....
Abstract. Data from the expression of P 1 , and k antigens on somatic cells in culture are presented. A tentative biosynthetic pathway system is proposed, where antigen precursor specificity. The antigen, which appears to be a public skin fibroblasts, controlled red blood lymphocytes by proposed Ff system.
General chemistry courses serve as foundational curriculum within most STEM undergraduate curricula, and hence, it is essential to assess student knowledge application of learning outcomes for such Introduction Chemistry Organic Chemistry. Within the United States, paper-and-pencil examinations are typical measuring understanding course content. In this project, an alternative written examinations, we implemented individual oral examinations. The purpose article provide guidance on how...
An unusual glycoprotein variant (Pj) was found inherited through a caucasian family exhibiting atypical N and Nvg blood-group reactivities. Pj erythrocytes are blood-group-MS homozygous have normal sialic acid content. On sodium dodecyl sulphate/polyacrylamide-gel electrophoresis the contains new component of 24kDa apparent molecular mass in monomeric state which is sharply stained by periodic acid/Schiff reagent. Both blood-group-MN (alpha) -Ss (delta) glycoproteins were present. Homodimers...
The most popular method to synthesize polychlorophosphazenes, the parent of a prominent class inorganic polymers, is ring-opening polymerization (ROP) [PCl2N]3. In contrast accepted (SN1-initiated) ROP mechanism that begins with heterolytic P–Cl bond cleavage in [PCl2N]3, our quantum mechanical (QM) calculations suggest can proceed through SN2-like route which one [PCl2N]3 be attacked by neighboring and hence transform four-center transition state (4C PNPCl TS), yielding cyclic...
Abstract. After treatment with the culture supernatant of Bacteroides fragilis or an endo‐β‐galactosidase from Escherichia freundii , human red blood cells are T k ‐activated, i.e. agglutinable by BS II lectin and their group I i activities reduced. These results suggest that B. produces activity main antigenic determinant polyagglutinable is a terminal N‐acetyl‐glucosamine residue.
The chemical acetylation of RBC bearing the acquired B antigen led to disappearance agglutinability by anti-B and restored A1 specificity. same results are obtained using transformed in vitro a Clostridium Tertium filtrate, where deacetylase was reported.
S ummary . A second example of anti‐Pr a was recognized in newborn infant which exhibited several signs developmental disease. The antibody complement‐fixing 19S IgM and showed high thermal range but no detectable haemolytic anaemia associated. It gave negative reactions with panel animal cells as well two samples human En(a‐) cells. latter, however, could absorb the antibody.
HBT-Cy 1 has been previously reported as a highly selective fluorescent probe for lysosome visualization in live cells. To further investigate the role of structural components selectivity, cyanine based series (2-5) have synthesized good yields by connecting benzothiazolium (Cy) with 2-hydroxyphenylbenzothiazole (HBT) via meta phenylene ring. Probes 2-5 exhibited exceptional photophysical properties including bright red-emission (λem≈ 630-650 nm), large Stokes shift (Δλ > 130 nm) and high...