A5018779514- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Biochemical and Molecular Research
- Hemoglobinopathies and Related Disorders
- HIV/AIDS drug development and treatment
- Metabolism and Genetic Disorders
- Ion Transport and Channel Regulation
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Adenosine and Purinergic Signaling
- Glycosylation and Glycoproteins Research
- HIV Research and Treatment
- RNA modifications and cancer
- DNA Repair Mechanisms
- Blood properties and coagulation
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Ion channel regulation and function
- Growth Hormone and Insulin-like Growth Factors
- Fetal and Pediatric Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Fungal and yeast genetics research
- Prenatal Screening and Diagnostics
ESPCI Paris
2018-2024
Université Paris Sciences et Lettres
2018-2024
Centre National de la Recherche Scientifique
2018-2024
Laboratoire Plasticité du Cerveau
2019-2021
Université des Lettres et des Sciences Humaines de Bamako
2021
Inserm
1999-2013
Délégation Paris 5
2006-2013
Université Paris Cité
2003-2013
Sorbonne Paris Cité
2012
Institut Necker Enfants Malades
2002-2003
cDNA clones encoding a human blood group Rh polypeptide were isolated from bone marrow library by using polymerase chain reaction-amplified DNA fragment the known common N-terminal region of proteins. The entire primary structure has been deduced nucleotide sequence 1384-base-pair-long clone. Translation open reading frame indicates that protein is composed 417 amino acids, including initiator methionine, which removed in mature protein, lacks cleavable sequence, and no consensus site for...
The RH (rhesus) blood group locus from RhD-positive donors is composed of two homologous structural genes, one which encodes the Cc and Ee polypeptides, whereas other, missing in RhD-negative condition, D protein that carries major antigen system. Recently, different splicing isoforms transcribed CcEe gene were isolated. We report now characterization other Rh clones, RhII RhXIII, generated by alternative choices for poly(A) addition sites identified as RhD transcripts. That these cDNAs...
An RhD-negative woman whose partner is heterozygous may have preexisting anti-RhD antibodies that or not affect a subsequent fetus, depending on whether it heterozygous. A safe method of determining fetal RhD type early in pregnancy would eliminate the risks to an fetus fetal-blood sampling serial amniocenteses.
ABSTRACT The autophagy-lysosome pathway plays a fundamental role in the clearance of aggregated proteins and protection against cellular stress neurodegenerative conditions. Alterations autophagy processes, including macroautophagy chaperone-mediated (CMA), have been described Parkinson disease (PD). CMA is selective autophagic process that depends on LAMP2A (lysosomal-associated membrane protein 2A), mammal bird-specific glycoprotein translocates cytosolic containing KFERQ-like peptide...
ABSTRACT. Two non-erythroid members of the erythrocyte Rhesus (Rh) protein family, RhBG and RhCG, have been recently cloned in kidney. These proteins share homologies with specific NH3/NH4+ transporters (Mep/Amt) primitive organisms plants. When expressed a Mep-deficient yeast, RhCG can function as bidirectional transporter. The aim this study was to determine intrarenal intracellular location rat RT-PCR on microdissected nephron segments demonstrated expression mRNAs encoding distal...
The Rhesus (Rh) proteins are a family of integral membrane found throughout the animal kingdom that also occur in number lower eukaryotes. significance Rh derives from their presence human red blood cell membrane, where they constitute second most important group antigens used transfusion medicine after ABO group. related to ammonium transport (Amt) protein and there is considerable evidence that, like Amt proteins, function as ammonia channels. We have now solved structure rare bacterial...
Renal ammonium (NH3 + NH4+) transport is a key process for body acid-base balance. It well known that several ionic systems allow NH4+ transmembrane translocation without high specificity NH4+, but it still debated whether NH3, and more generally, gas, may be transported by proteins. The human Rh glycoproteins have been proposed to mediate transport. Transport of and/or NH3 the epithelial C glycoprotein (RhCG) physiological importance in renal excretion because RhCG mainly expressed distal...
A new gene closely related to the glycophorin (GPA) and B (GPB) genes has been identified in normal human genome as well that of persons with known alterations GPA and/or GPB expression. This gene, called E (GPE), is transcribed into a 0.6-kb message which encodes 78-amino-acid protein putative leader peptide 19 residues. The first 26 amino acids mature are identical those M-type (GPA), but C-terminal domain (residues 27-59) differs significantly from glycophorins (GPA GPB). GPE consists...
Diffuse bronchiectasis is a common problem in respiratory clinics. We hypothesized that mutations the solute carrier 26A9 (SLC26A9) gene, encoding for chloride (Cl(-)) transporter mainly expressed lungs, may lead to defects mucociliary clearance. describe two missense variants SLC26A9 gene heterozygote patients presenting with diffuse idiopathic : p.Arg575Trp, identified patient also p.Phe508del CFTR gene; and p.Val486Ile. Expression of both mutants Xenopus laevis oocytes abolished...