A5079296559- Luminescence and Fluorescent Materials
- Photochemistry and Electron Transfer Studies
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- Photochromic and Fluorescence Chemistry
- Mitochondrial Function and Pathology
- Porphyrin and Phthalocyanine Chemistry
- bioluminescence and chemiluminescence research
- Electrochemical Analysis and Applications
- Electron Spin Resonance Studies
- Bioactive natural compounds
- Protein Interaction Studies and Fluorescence Analysis
- Nanoplatforms for cancer theranostics
- Spectroscopy and Quantum Chemical Studies
- Advanced biosensing and bioanalysis techniques
- Bioactive Compounds and Antitumor Agents
- Photoacoustic and Ultrasonic Imaging
- Sulfur Compounds in Biology
- Aluminum toxicity and tolerance in plants and animals
- Natural product bioactivities and synthesis
- Antibiotics Pharmacokinetics and Efficacy
- Neurogenesis and neuroplasticity mechanisms
- Photodynamic Therapy Research Studies
- Sulfur-Based Synthesis Techniques
University of Connecticut
2024-2025
University of Akron
2016-2023
St. Jude Children's Research Hospital
2020-2022
An NIR-emitting probe (λem ∼ 700 nm) with a large Stokes shift (Δλ ≈ 234 is synthesized by using excited-state intramolecular proton transfer (ESIPT). The phenolic proton, which controls ESIPT, acts as switch to give strong fluorescence at pH 5. can selectively show lysosome organelles, therefore leading without exhibiting "an alkalinizing effect".
A red-emitting probe with a large Stokes shift (Δ<italic>λ</italic>≈ 130 nm) exhibits great selectivity and sensitivity for cell nucleus imaging.
Bright, photostable, and nontoxic fluorescent contrast agents are critical for biological imaging. "Self-healing" dyes, in which triplet states intramolecularly quenched, enable fluorescence imaging by increasing fluorophore brightness longevity, while simultaneously reducing the generation of reactive oxygen species that promote phototoxicity. Here, we systematically examine self-healing mechanism cyanine-class organic fluorophores spanning visible spectrum. We show Baird aromatic...
A bright red-emitting flavonoid derivative was synthesized, which exhibited a large Stokes shift (Δ<italic>λ</italic> > 150 nm) and high fluorescence quantum yields (<italic>ϕ</italic><sub>fl</sub> = 0.10–0.35).
Pyrene–benzothiazolium probe for visualizing lysosome in live cells.
Green-emitting styryl pyridinium probe (EPN) was developed for live-cell imaging applications. EPN exhibited a large Stokes shift (Δλ ≈150 nm) due to efficient ICT across π-acceptor system. Probe exceptional...
Two NIR-emitting donor-π-acceptor (D-π-A) type regioisomeric styryl pyridinium dyes (1a–1b) were synthesized and studied for their photophysical performance environment sensitivity. The two regioisomers, 1a 1b, exhibited interesting properties including, longer wavelength excitation (λex ≈ 530–560 nm), bright near-infrared emission (λem 690–720 high-fluorescence quantum yields (ϕfl 0.24–0.72) large Stokes’ shift (∆λ 150–240 nm) high-environmental Probe’s in different environmental conditions...
A series of benzothiazolium-based hemicyanines (<bold>3a–3f</bold>) have been synthesized.
Highly bio-compatible probes (LC50 > 75 μM) with large Stokes shifts (Δ<italic>λ</italic>> 150 nm) for quick staining of lysosomes (≈20 min) in live cells.
Bright red to NIR emitting cyanine probes 2-3 were synthesized in very good yields. Probes exhibited excellent fluorescent quantum yields (ϕfl ≈ 0.1-0.4) and large Stokes shift (Δλ > 150 nm) due efficient intramolecular charge transfer (ICT) the conjugated π system. Organelle specificity of these was investigated by live cell fluorescence confocal microscopy studies. Probe 3 ability visualize nucleus mitochondria simultaneously samples during imaging experiments. However, structurally...
HBT-Cy 1 has been previously reported as a highly selective fluorescent probe for lysosome visualization in live cells. To further investigate the role of structural components selectivity, cyanine based series (2-5) have synthesized good yields by connecting benzothiazolium (Cy) with 2-hydroxyphenylbenzothiazole (HBT) via meta phenylene ring. Probes 2-5 exhibited exceptional photophysical properties including bright red-emission (λem≈ 630-650 nm), large Stokes shift (Δλ > 130 nm) and high...
The excited-state deactivation pathway of the push–pull pyrene derivative (EPP), a molecule emitting bright red fluorescence, has been studied in several solvents using quantum chemical calculations, femtosecond time-resolved fluorescence up-conversion spectroscopy, and transient absorption spectra (fs-TA). From steady-state spectra, EPP shown strong negatively solvatochromic behavior non-solvatochromic emission revealing decreased dipole moment upon excitation. Femtosecond measurements have...
A highly sensitive probe for the detection of fluoride by triggered NIR emission.