A5043629415- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Hepatitis B Virus Studies
- Platelet Disorders and Treatments
- Microfluidic and Bio-sensing Technologies
- Ubiquitin and proteasome pathways
- Integrated Circuits and Semiconductor Failure Analysis
- Cellular Mechanics and Interactions
- interferon and immune responses
- Telomeres, Telomerase, and Senescence
- Molecular Biology Techniques and Applications
National Institute of Immunohaematology
2020-2025
Indian Council of Medical Research
2020-2024
Leukocyte adhesion deficiency (LAD) syndrome is a group of inborn errors immunity characterized by defect in the cascade activation and leading to failure leukocyte migrate site tissue injury. Three different types LAD have been described. The most common subtype type 1 (LAD1) caused due defects ITGβ2 gene. 2 (LAD2) mutations SLC35C1 gene generalized loss expression fucosylated glycans on cell surface 3 (LAD3) FERMT3 resulting platelet function along with immunodeficiency. There paucity data...
<title>Abstract</title> Wiskott-Aldrich Syndrome (WAS) is a rare X-linked recessive disorder characterized by microthrombocytopenia, eczema, combined immunodeficiency, and an increased risk of malignancies. Previous research has highlighted genomic instability in WAS patients; however, the specific dynamics double-strand break (DSB) repair these individuals are not fully understood. Phosphorylation γH2AX serves as early indicator DSBs, while 53BP1 binds to damaged chromatin γH2AX-dependent...
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of immune dysregulation characterized by hyperactivation the system, excessive cytokine secretion and severe systemic inflammation. HLH classified as familial (FHL) when associated with mutations in PRF1, UNC13D, STX11 , STXBP2 genes. There limited information available about clinical mutational spectrum FHL patients Indian population. This study retrospective analysis 101 molecularly over last 10 years from 20 different referral centers...
Abstract A comprehensive evaluation of immune parameters while screening for inborn errors immunity (IEIs) provides valuable information about the underlying defect. In 2019, ICMR‐National Institute Immunohaematology adopted a panel modified from Euroflow consortium‐recommended PIDOT tube, difference being addition HLA‐DR. present study, we evaluate utility HLA‐DR in our panel. The expression on CD3 + T, its CD4+ and CD8+ subsets, natural killer (NK) double‐negative T cells (DNT) was...
Abstract Autoimmune lymphoproliferative syndrome (ALPS) is caused due to defects in the Fas-mediated apoptotic pathway. This disease characterised by chronic non -malignant lymphoproliferation, autoimmune cytopenias and accumulation of double-negative T cells. FAS most commonly affected gene observed patients with ALPS. There a paucity data other ALPS associated genes. Mutations FADD extremely rare, date, only five homozygous mutation exon 2 one patient compound heterozygous are reported....