A5002319978- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- COVID-19 and healthcare impacts
- Blood disorders and treatments
- Ethics and Legal Issues in Pediatric Healthcare
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Malaria Research and Control
- Autoimmune and Inflammatory Disorders Research
- Renal and related cancers
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Tuberculosis Research and Epidemiology
- Adolescent and Pediatric Healthcare
- Hemophilia Treatment and Research
- Sarcoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
Sir Ganga Ram Hospital
2013-2025
Institute of Child Health
2013-2024
Sir Ganga Ram Hospital
2012-2024
Indraprastha Apollo Hospitals
2010-2022
Kalawati Saran Children's Hospital
2022
Max Super Speciality Hospital
2018-2022
University of Guelph
2022
Bai Jerbai Wadia Hospital for Children
2022
Rajiv Gandhi Cancer Institute and Research Centre
2022
Marymount University
2022
Mendelian Susceptibility to Mycobacterial diseases (MSMD) are a group of innate immune defects with more than 17 genes and 32 clinical phenotypes identified. Defects in the IFN-γ mediated immunity lead an increased susceptibility intracellular pathogens like mycobacteria including attenuated Mycobacterium bovis -Bacillus Calmette-Guérin (BCG) vaccine strains non-tuberculous environmental (NTM), Salmonella , fungi, parasites Leishmania some viruses, otherwise healthy individuals. Mutations...
Severe combined immunodeficiency (SCID) represents one of the most severe forms primary (PID) disorders characterized by impaired cellular and humoral immune responses. Here, we report clinical, immunological, molecular findings in 57 patients diagnosed with SCID from India. Majority our (89%) presented within 6 months age. The common clinical manifestations observed were recurrent pneumonia (66%), failure to thrive (60%), chronic diarrhea (35%), gastrointestinal infection (21%) oral...
Chronic granulomatous disease (CGD) is an inherited defect in phagocytic respiratory burst that results severe and life-threatening infections affected children. Single center studies from India have shown proportion of autosomal recessive (AR) CGD more than reported the West. Further, patients high mortality rates due to late referrals difficulties accessing appropriate treatment. However, there lack multicentric collaborative data on India.To describe infection patterns, immunological,...
Leukocyte adhesion deficiency (LAD) syndrome is a group of inborn errors immunity characterized by defect in the cascade activation and leading to failure leukocyte migrate site tissue injury. Three different types LAD have been described. The most common subtype type 1 (LAD1) caused due defects ITGβ2 gene. 2 (LAD2) mutations SLC35C1 gene generalized loss expression fucosylated glycans on cell surface 3 (LAD3) FERMT3 resulting platelet function along with immunodeficiency. There paucity data...
Management of low-grade gliomas (LGG) can be a challenge, particularly when not resectable and refractory or recurrent following standard treatments. We undertook retrospective analysis 2 institutions' experiences treating children for progressive LGG with bevacizumab-based therapy (BBT).Inclusion criteria were patients younger than 18 years age who had previously failed one more lines therapy. Treatment was intravenous bevacizumab 10 mg/kg irinotecan 125 to 150 mg/m2 every weeks.Sixteen...
Cure rates for children with cancer in India lag behind that of high-income countries. Various disease, treatment and socio-economic related factors contribute to this gap including barriers timely access diagnostic therapeutic care. This study investigated accessing care from symptom onset beginning treatment, perspectives caregivers India.Semi-structured in-depth interviews were conducted (< 18 years) diagnosed seven tertiary hospitals across New Delhi Hyderabad. Purposive sampling...
Introduction: Hyper-IgE Syndrome (HIES) is a rare inborn error of immunity (IEI) characterized by constellation symptoms related to susceptibility Staphylococcal skin and pulmonary infections, eczema, raised serum IgE (>2,000 IU/ml), craniofacial anomalies, recurrent bone fractures. Data on HIES from the Indian subcontinent scarce restricted small case series reports. This first compilation national data HIES. Materials Methods: A total 103 cases clinically diagnosed treated as were analyzed...
Background There is paucity of literature on XLA from developing countries. Herein we report the clinical and molecular profile outcome in a multicenter cohort patients with India. Methods Data all regional centers supported by Foundation for Primary Immunodeficiency Diseases (FPID), USA other institutions providing care to PIDs were collated. Diagnosis was based European Society Immunodeficiencies (ESID) criteria. Results We received details 195 provisional diagnosis 12 centers. At final...
The literature on B-non-Hodgkin lymphoma (NHL) in India is restricted to individual hospital data. study aimed evaluate the epidemiology and outcome of B-NHL our country. One hundred ninety-one patients from 10 centers diagnosed between 2013 2016 were analyzed retrospectively. B/T lymphoblastic with inadequate data excluded. median age was 88 months (IQR: 56, 144) an M:F ratio 5.6:1. Undernourishment stunting seen 36.5% 22%. Primary site abdomen 66.5%. Hypoalbuminemia noted 82/170 (48.2%)....
Background: Patients with cancer are at a higher risk of getting infected the severe acute respiratory syndrome coronavirus 2 owing to their immunocompromised state. Providing care these patients amidst first wave disease-2019 (COVID-19) pandemic was extremely challenging. Objectives: This study aimed evaluating clinical profile and disease-related outcomes pediatric hematological illnesses cancer. Materials Methods: retrospective conducted tertiary center in North India during from March...
In the last four decades, survival in childhood cancer India has improved significantly, but we increasingly face question that challenged providers high-income countries: when care becomes futile and merely prolongs suffering, how should be addressed? This position statement was prepared by a panel Pediatric Hematology-Oncology chapter of Indian Academy Pediatrics (IAP-PHO), using process endorsed Executive Committee IAP-PHO. The consisted stakeholders who are committed to improving...
Abstract Background Hemophilia A (HA) is an X-linked inherited bleeding disorder caused by reduced factor VIII (FVIII) levels. Approximately 10–15% of patients with severe HA (SHA) do not present the anticipated pattern. Here, we assessed phenotypic severity hemophilia using rotational thromboelastometry (ROTEM) and activated partial thromboplastin time-clot waveform analysis (APTT-CWA). Methods Patients diagnosed were enrolled. Clinical phenotype assignment was performed according to...
Abstract Background Both ketamine–midazolam and propofol are frequently used in pediatric oncology units for procedural sedation. However, there no prospective, randomized comparative trials (RCT) comparing the two groups when procedure is performed by nonanesthesiologists. Objective To compare ketamine + midazolam (group A) B) as sedative agents intrathecal chemotherapy with regard to efficacy, side effects, time induction, recovery, smoothness of recovery. Methods A partially‐blinded RCT...
Abstract Background High‐dose methotrexate (HDMTX) is recommended to be administered with serial monitoring of (MTX) levels, which may not universally feasible in resource‐limited settings. In this study, we evaluated the overall experience administration HDMTX at our center by a single drug level 54 h from start MTX infusion. Methods This retrospective study was performed tertiary hospital north India, over 5‐year period (2011‐2015). All patients <18 years age newly diagnosed acute...