Our purpose was to assess sustained delivery and enhanced efficacy of pirfenidone-loaded nanoparticles after intratracheal instillation.

Percutaneous transcatheter closure of ruptured sinus valsalva aneurysm was attempted in eight patients between January 1995 and March 2003 as an alternative strategy to surgery this technique at present is accepted therapeutic modality for various intracardiac defects. The age range 14-35 years, all were male, seven symptomatic class III one IV on medical treatment. Two-dimensional color Doppler echocardiography revealed rupture right coronary into ventricle five noncoronary atrium three...

The success with occlusion devices for the closure of atrial septal defects and patent ductus arteriosus prompted transcatheter single multiple muscular ventricular (VSD). procedure VSD was first attempted by Lock et al. in 1988 originally designed other intracardiac (Rashkind umbrella device, clamshell, Cardioseal, coils, Sideris buttoned device etc.) were used a variable rate residual shunt. Recently, specially Amplatzer occluder are use. has been undergoing clinical trial since 1998 after...

<h3>Objective</h3> To determine whether adverse effects such as elevated intraocular pressure and cataracts, which are lower with dexamethasone when compared fluocinolone acetonide or triamcinolone acetonide, may be explained in part by the differences drug lipophilicity partitioning of these drugs into trabecular meshwork lens. <h3>Methods</h3> The n-octanol/phosphate-buffered saline (pH 7.4) partition coefficient (log distribution [D]) bovine/human ocular tissue coefficients were...

The influence of drug properties including solubility, lipophilicity, tissue partition coefficients, and in vitro transscleral permeability on ex vivo delivery from corticosteroid suspensions was determined. Solubility, tissue/buffer coefficients for bovine sclera choroid-retinal pigment epithelium (CRPE), sclera-choroid-retinal (SCRPE) transport were determined at pH 7.4 triamcinolone, prednisolone, dexamethasone, fluocinolone acetonide, triamcinolone budesonide solution. Ex assessed Brown...

Loss of an eye can be caused by cancer, trauma, or congenital defects. A loss creates functional, esthetic, and psychological lacunae in individual's personal professional life. Rehabilitation ocular defect done a custom prosthesis fabricated with heat cure polymethylmethacrylate. The custom-made provides better fit, is more comfortable to use gives cosmetic results than stock prosthesis. main objective this article describe new technique customization using digital photograph the patient's...

Cranial vault defects may be acquired or congenital in origin. Rehabilitation of these patients often poses challenge to the operating team and prosthodontist. Polymethylmethacrylate is a commonly used alloplastic graft material which for fabrication cranial prosthesis. Nowadays, with advancement bioengineering, custom-made template prosthesis can made by rapid prototyping technology (RPT) patient three-dimensional (3D) computed tomography (CT) scan images. This series two cases explained...

Left atrial myxoma is the most common intracardiac tumour. It could be seen in patients between 3-83 years of age, with majority presenting fifth decade life as sporadic cases (90%) and second familial (10%) 1. an important source central nervous system embolism 2. Elderly often present non specific symptoms that are overlooked absence a supporting cardiac history which makes early diagnosis challenging. This case report discusses unusual presentation left elderly patient.

Cranial defects secondary to trauma, surgery or pathological causes, result in large cranial imperfection, which affects the appearance of patient as well results sinking flap syndrome. Rehabilitation such a defect can be done using prosthetic options like custom-made polymethyl methacrylate (PMMA) prosthesis surgical outer table calvarial graft segments. It is usually observed that conventional moulage impression defective site most difficult task. The accuracy affected by impression, cast...

Maxillofacial defect is of great concern physically, emotionally, and psychologically for a patient. However, it an even bigger challenge team attempting rehabilitation, as crucial decision has to be made between surgical approach and/or prosthetic rehabilitation. if both are combined, will result in best esthetics function with ease maintainance, resulting sucessful This case report represents auricular rehabilitated combination implants bar-retained silicone prosthesis.A 38-year-old male...

We report a case of hydatid cyst the mediastinum in 32-year-old female patient who was admitted with chest pain. CT scan reported posterior mediastinal mass towards right side. Surgical exploration revealed loculated on side, adherent to overlying lung and underlying bone. Posterolateral thoracotomy performed for aspiration excision. The discharged albendazole.

Background: Facial defects can be acquired or congenital, but irrespective of etiology, any maxillofacial structure if damaged missing will result in an unaesthetic and unappealing personality individual. Orbital are very evident effect the appearance social front Many modalities available to rehabilitate defect orbit prosthetic rehabilitation with silicone prosthesis is a simple effective approach. Retention generally achieved by engaging undercuts using mechanical accessories skin...

Soft palate is a part of the composed muscles and mucous membrane.It divides oropharynx from nasopharynx.Soft along with lateral posterior pharyngeal walls create three-dimensional muscular valve which known as velopharyngeal (VP) sphincter.This VP sphincter allows normal breathing prevents regurgitation food fluids in nasal cavity.It also required other functions such swallowing, blowing, sucking, whistling sneezing.Any defect soft palate, i.e., structurally or neurologically will lead to...

Microstomia is a clinical condition of reduced mouth opening that can be acquired or congenital in origin. Problems associated with microstomia related to function, esthetics, both. Management due facial burns complex the presence hypertrophic and contracture scars. Available treatment options broadly classified as surgical, nonsurgical, Splints used prevent contraction perioral musculature recuperate lost opening. Various intraoral extraoral, tooth-borne tissue-borne, static dynamic...

Introduction: Gall bladder carcinoma was first described in 17 th century, Incidence of gall stones increased over time and so is the incidence bladder.Still tumor remains characterized by an unfavourable prognosis due to silent progression clinical course limited knowledge its aetiology poor scientific capability for epidemiological forecasting.The GBC varies different parts world.Overall ranges from 0.11/100000 10.6/100000 cancer registries worldwide [1].Our study attempt establish...

Maxillectomy defects are usually due to surgical resection of carcinoma and results in a distinctive complication. In maxillectomy, there is communication between the oral nasal cavity which aggravates problem limits treatment option. If patient presents with additional xerostomia, then level difficulty increases many folds. This case report maxillectomy undergoing radiotherapy resulting xerostomia. The wanted have definitive functional restoration. Due complexity situation conventional...

Introduction-LaparoscopicCholecystectomy is the gold standard procedure for symptomatic cholelithiasis years.Laparoscopic cholecystectomy refined over years to increase its efficacy, decrease complication rates and cosmoses .Single incision laparoscopic being one of them.SILC has some documented advantages in comparison four ports LC.Use Harmonic Ace SILC further improved efficiency this complications rate been decreased, thus making a promising surgical technique treatment...