A5039230944- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Fungal and yeast genetics research
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Advanced Drug Delivery Systems
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Nerve injury and regeneration
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Electrospun Nanofibers in Biomedical Applications
- Bacterial Identification and Susceptibility Testing
MRIGlobal
2020-2023
Carnegie Mellon University
2013
Stony Brook University
2010
Understanding the patterns and causes of phenotypic divergence is a central goal in evolutionary biology. Much work has shown that mRNA abundance highly variable between closely related species. However, extent mechanisms post-transcriptional gene regulatory evolution are largely unknown. Here we used ribosome profiling to compare transcript translation efficiency two yeast species (S. cerevisiae S. paradoxus). By comparing interspecies differences sequence features, show leaders codon bias...
Rapid, specific, and sensitive identification of microbial pathogens is critical to infectious disease diagnosis surveillance. Classical culture-based methods can be applied a broad range but have long turnaround times. Molecular methods, such as PCR, are time-effective not comprehensive may detect novel strains. Metagenomic shotgun next-generation sequencing (NGS) promises specific characterization any pathogen (viruses, bacteria, fungi, protozoa) in less biased way. Despite its great...
ABSTRACT Metagenomics is emerging as an important tool in biosurveillance, public health, and clinical applications. However, ease-of-use for execution data analysis remains a barrier-of-entry to the adoption of metagenomics applied health forensics settings. In addition, these venues often have more stringent requirements reporting, accuracy, precision than traditional ecological research role technology. Here, we present PanGIA ( Pan - G enomics I nfectious A gents), novel bioinformatics...
SUMMARY In the analysis of genomic sequence data, so-called “alignment free” approaches are often selected for their relative speed compared to alignment-based approaches, especially in application distance comparisons and taxonomic classification 1,2,3,4 . These methods typically reliant on excising K-length substrings input sequence, called K-mers 5 context machine learning, K-mer based feature vectors have been used applications ranging from amplicon sequencing predictive modeling...
Understanding the patterns and causes of phenotypic divergence is a central goal in evolutionary biology. Much work has shown that mRNA abundance highly variable between closely related species. However, extent mechanisms post-transcriptional gene regulatory evolution are largely unknown. Here we used ribosome profiling to compare transcript translation efficiency two yeast species (S. cerevisiae S. paradoxus). By comparing interspecies differences sequence features, show leaders codon bias...
Current delivery systems for vaccines present major logistical problems when large populations need to be vaccinated within a short time period, such as in the case of pandemic. An efficient and effective method pandemic vaccination is driving force research performed by our group. The proposed alternative technique consists self-administrable patch made electrospun nanofibers, where antigens adjuvants are imbedded during electrospinning process. This allows quantities immunogens...