Abstract Over 80% of diffuse intrinsic pontine gliomas (DIPGs) harbor a point mutation in histone H3.3 where lysine 27 is substituted with methionine (H3.3K27M); however, how the affects kinetics and function PcG proteins remains elusive. We demonstrate that H3.3K27M prolongs residence time search Ezh2, but has no effect on its fraction bound to chromatin. In contrast, Cbx7, decreases show increasing expression Cbx7 inhibits proliferation DIPG cells time. Our results highlight directly...

Metamaterials have been increasingly used in the past few decades design of novel microwave circuits and sensor systems. This paper deals with a split-ring resonator (SRR) for nondestructive evaluation (NDE) applications. Building on prior work this field, modified is imaging composites. The tip sensing ring extended, reference introduced to tailor fit NDE A built-in calibration system, integration multiple sensors (high low frequencies), super resolution capability, high-Q factor are some...

Microwave nondestructive testing (NDT) techniques show promise for composite inspection due to microwave signals' ability penetrate and interact with internal structures. However, current imaging approaches have poor spatial resolution, struggling distinguish defects from defect-free regions. This limits reliable subsurface analysis widespread adoption. paper introduces a novel multi-frequency fusion method using an open-ended waveguide deep learning enhance defect detection accuracy in...

The roots are a vital organ for plant growth and health. opaque surrounding environment of the complicated process means that in situ non-destructive root phenotyping face great challenges, which thus spur research interests. existing methods either unable to provide high-precision high accuracy detection, or they change destructive Thus,we propose develop an ultra-wideband microwave scanning method uses time reversal achieve nondestructively. To verify method's feasibility, we studied...

Metamaterials are engineered periodic structures designed to have unique properties not encountered in naturally occurring materials. One such unusual property of metamaterials is the ability exhibit negative refractive index over a prescribed range frequencies. A lens made can achieve resolution beyond diffraction limit. This paper presents design metamaterial and its use far-field microwave imaging for subwavelength defect detection nondestructive evaluation (NDE). Theoretical formulation...

Magnetic Barkhausen noise (MBN) is measured in low carbon steels and the relationship between content parameter extracted from MBN signal has been investigated. The experimentally by fitting original profiles with two Gaussian curves. gap peaks (ΔG) of fitted curves shows a better linear contents samples experiment. result validated simulation Monte Carlo method. To ensure sensitivity measurement, advanced multi-objective optimization algorithm Non-dominant sorting genetic III (NSGA III)...

Abstract Composites are being increasingly used in various industries due to their lower cost and superior mechanical properties over traditional materials. They nevertheless vulnerable defects during manufacturing or usage which can cause failure of critical engineering structures. Hence, there is a growing need for nondestructive evaluation (NDE) composites detect such defective structures avoid significant loss damages. Microwave NDE has several advantages other existing techniques...

This work investigates the use of Lie symmetries for assessing and improving observability dynamical systems under examined sensor setups.The framework symmetry is extended to account unmeasured hence unknown inputs.An efficient algorithm developed calculate translation scaling nonlinear with inputs.The assess a given system demonstrated, i.e. in theory whether it would be successful identify dynamic states, parameters inputs from measurements.The further shows potential application...

Abstract Underbalanced drilling (UBD) has been widely used as a means of reducing formation damage during drilling. The benefit reduced results from the fact that borehole pressure is intentionally maintained to be lower than pore pay zone. UBD operations require additional surface equipment such separators and reserve tanks process store produced reservoir fluids. Selection for involves using method predict fluid inflow rate volume. Such not available in literature horizontal wells. This...

Taking the SaErTU and Putaohua oil layers in L29 well area of LHP oilfield northern Songliao Basin as research object, In response to difficulty interference between thin interbedded sand mudstone strong reflection strata, which have a significant impact on fine prediction bodies, stratigraphic model is established based geological characteristics target layer eliminate reflection; Then add body its interior, establish interlayer model, obtain that more line with actual situation layer....

The aim of this paper is to develop the concept and a prototype an intelligent mobile robotic platform that integrated with nondestructive evaluation (NDE) capabilities for autonomous live inspection repair. In many industrial environments, such as application power plant boiler inspection, human inspectors often have perform hazardous challenging tasks. There significant chance injury, considering confined spaces limited visibility environment hazards pressurization improper water levels....

Multifunctional tactile sensors that can mimic the sensory capabilities of human skin to perceive various external static and dynamic stimuli are essential interact with environment humans for wearable electronics soft intelligent robotics. Here, inspired by skin, we report a textile-based sensor capable multifunctional sensing personalized healthcare monitoring robotic control. The consists triboelectric nanogenerator layer function fast adapting (FA) mechanoreceptors piezoresistive achieve...

Abstract With the decline of conventional resources, tight oil reserves in Daqing oilfield are becoming increasingly important, but measuring relative permeability and determining production forecasts through laboratory core flow tests for formations both difficult time consuming. Results testing questionable due to very small pore volume low reservoir rock, there challenges controlling critical parameters during special analysis (SCAL) tests. In this paper, protocol workflow a digital rock...

The Architecture Analysis and Design Language (AADL) is widely used in the modeling, analysis verification of dependability-critical system. Previously, we have implemented multi-objective (based on dependability cost) architecture optimization AADL model. cost attribute however, was only assumed to be a simple numerical value. It cannot accurately reflect actual In addition, there still lack mature modeling methods for AADL. this paper, develop method latest AADL2. factors that affect...

Currently, AADL has gradually become as one of the standards for architecture design complex embedded system. It is widely used in aerospace, automotive electronics and other fields analysis high dependability-critical systems. Although Error Model annex (EMA) can well support error modeling, there still a lack technical method multiobjective (based on dependability cost) optimisation dependable In order to achieve model, an effective transform model into equivalent models. This paper...

Composite material usage is rapidly increasing within various industries due to their unique properties. Though having better damage tolerance and corrosion resistance than metals, the presence of defects in composites may significantly affect material’s integrity strength. This paper presents a multi-frequency nearfield microwave imaging system tailored evaluate multi-layered composite materials. The employs data fusion techniques utilizing signals while improving image quality. Results...