A5079648062- Mitochondrial Function and Pathology
- Emotion and Mood Recognition
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- EEG and Brain-Computer Interfaces
- Nutritional Studies and Diet
- Sentiment Analysis and Opinion Mining
- ECG Monitoring and Analysis
- Speech and dialogue systems
- Tea Polyphenols and Effects
- Digital Communication and Language
- Advanced Text Analysis Techniques
- DNA Repair Mechanisms
- Phytoestrogen effects and research
- Health, Environment, Cognitive Aging
- Thermoregulation and physiological responses
- Vitamin C and Antioxidants Research
- Adipose Tissue and Metabolism
- Coenzyme Q10 studies and effects
- Cardiovascular Health and Risk Factors
- Genetic Neurodegenerative Diseases
- Natural Language Processing Techniques
- Obesity, Physical Activity, Diet
- Multisensory perception and integration
- Biochemical Acid Research Studies
Japan Advanced Institute of Science and Technology
2020-2025
Kao Corporation (Japan)
2018-2025
Osaka University
2024
University of Tsukuba
2013-2022
ENVIRON (United States)
2016-2017
Mitochondria are dynamic organelles, and their fusion fission regulate cellular signaling, development, mitochondrial homeostasis, including DNA (mtDNA) distribution. Cardiac myocytes have a specialized cytoplasmic structure where large mitochondria aligned into tightly packed myofibril bundles; however, recent studies revealed that dynamics also plays an important role in the formation maintenance of cardiomyocytes. Here, we precisely analyzed vivo. The GTPase, Drp1, is highly expressed...
Data for healthcare applications are typically customized specific purposes but often difficult to access due high costs and privacy concerns. Rather than prepare separate datasets individual applications, we propose a novel approach: building general-purpose generative model applicable virtually any type of application. This encompasses broad range human attributes, including age, sex, anthropometric measurements, blood components, physical performance metrics, numerous healthcare-related...
Abstract Background The global prevalence of dementia is significantly increasing. Early detection and prevention strategies, particularly for mild cognitive impairment (MCI), are crucial but currently hindered by the lack established biomarkers. Here, we aimed to develop a high-precision screening method MCI combining D-amino acid profiles from peripheral blood samples with non-invasive subject information using nonlinear machine learning algorithms Methods A cross-sectional study was...
Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due their carrying a nuclear-encoded mtDNA polymerase with defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, resulting expression respiration defects. On the contrary, transmitochondrial mito-miceΔ large-scale deletion mutation (ΔmtDNA) also defects, but not phenotypes. Here, we resolved this discrepancy by...
Multimodal sentiment analysis has become a focus of research in recent years. However, most studies multimodal have considered only signals that are observable by humans, such as linguistic, audio and visual information, whereas the contribution fusion with unobservable signals, i.e., physiological not been comprehensively explored. In this study, we aim to investigate effects evaluating all models for different types estimation naturalistic human-agent interaction settings. Our results...
Chlorogenic acids (CGAs) reduce blood pressure and body fat, enhance fat metabolism. In roasted coffee, CGAs exist together with the oxidant component hydroxyhydroquinone (HHQ). HHQ counteracts antihypertensive effects of CGA, but its on CGA-induced oxidation (FOX) are unknown. Here we assessed CGA-enriched HHQ-reduced coffee FOX. Fifteen healthy male volunteers (age: 38 ± 8 years (mean SD); BMI: 22.4 1.5 kg/m2) participated in this crossover study. Subjects consumed test beverage (coffee)...
Abstract Studies in patients have suggested that the clinical phenotypes of some mitochondrial diseases might transit from one disease to another (e.g., Pearson syndrome [PS] Kearns-Sayre syndrome) single individuals carrying (mt) DNA with a common deletion (∆mtDNA), but there is no direct experimental evidence for this. To determine whether ∆mtDNA has pathologic potential induce multiple phenotypes, we used trans-mitochondrial mice heteroplasmic state wild-type mtDNA and (mito-mice∆)....
It has been reported that tea catechins increase energy metabolism, but their effect on resting metabolic rate (RMR) remains under debate. This study aimed to examine the of repeated intake metabolism in state middle-aged men and women. A total 30 women [13 women; age (mean ± SD) 52 4 years; BMI 21.9 2.2 kg/m2] were recruited. randomized, double-blind, crossover was conducted using a catechin-enriched beverage (611 mg catechins, 88 caffeine) placebo (0 81 as test beverages. After 2 weeks...
In human-agent interactions, it is necessary for the systems to identify current emotional state of user adapt their dialogue strategies. Nevertheless, this task challenging because states are not always expressed in a natural setting and change dynamically. Recent accumulated evidence has indicated usefulness physiological modalities realize emotion recognition. However, contribution time series signals interaction during been extensively investigated. This paper presents machine learning...
One of the main challenges in realizing dialog systems is adapting to a user's sentiment state real time. Large-scale language models, such as BERT, have achieved excellent performance estimation; however, use only linguistic information from user utterances estimation still has limitations. In fact, self-reported not necessarily expressed by utterances. To mitigate issue that true observable signals, psychophysiology and affective computing studies focused on physiological signals capture...
An interview for a job recruiting process requires applicants to demonstrate their communication skills. Interviewees sometimes become nervous about the because interviewees themselves do not know assessed score. This study investigates relationship between skill (CS) and self-efficacy level (SE) of through multimodal modeling. We also clarify difference effective features in prediction CS SE labels. For this purpose, we collect novel data corpus by using agent system where users experience...
The present study investigated whether combined ingestion of green tea catechins (GTC) and monoglucosyl hesperidin (GHES) influences the pharmacokinetic parameters polyphenols serum triglycerides (TG). We conducted 2 randomized, controlled trials. Study 1: 8 healthy male subjects participated in a crossover which they ingested test beverage containing GHES (0, 84, 168, or 336 mg GHES) with GTC, without GTC. After ingestion, changes plasma hesperetin (HEP) were measured. 2: 36 female (mean...
Regulation of mitochondrial respiration and morphology is important for maintaining steady-state hematopoiesis, yet few studies have comparatively evaluated the effects abnormal dynamics on blood-cell differentiation in isolation or combination. This study sought to explore these mouse models with one both following deficits: a large-scale deletion DNA (ΔmtDNA), accumulated varying extents, knockout fission factor Drp1. Each deficit was found independently provoke anemia but clearly...
Recently developed Bidirectional Encoder Representations from Transformers (BERT) outperforms the state-of-the-art in many natural language processing tasks English. Although contextual information is known to be useful for dialog act classification, fine-tuning BERT with has not been investigated, especially head final languages such as Japanese. This paper investigates whether performs well on classification Japanese open-domain conversation. In our proposed model, only utterance itself...
<sec> <title>BACKGROUND</title> Human health status can be measured on the basis of many different parameters. Statistical relationships among these parameters will enable several possible care applications and an approximation current individuals, which allow for more personalized preventive by informing potential risks developing interventions. Furthermore, a better understanding modifiable risk factors related to lifestyle, diet, physical activity facilitate design optimal treatment...
Human health status can be measured on the basis of many different parameters. Statistical relationships among these parameters will enable several possible care applications and an approximation current individuals, which allow for more personalized preventive by informing potential risks developing interventions. Furthermore, a better understanding modifiable risk factors related to lifestyle, diet, physical activity facilitate design optimal treatment approaches individuals.This study...
Abstract Marked accumulation of mitochondrial DNA (mtDNA) with a particular pathogenic mutation is necessary for the mutant mtDNA to express its pathogenicity as respiration defects. However, nuclear genome background, or physiological status, both, might also be important regulation mtDNAs, because most function controlled by polypeptides encoded in genome. To test this, we generated diabetic mice carrying large-scale deletion (ΔmtDNA) that loses six tRNA genes and seven structural...