A5067689090- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Air Quality Monitoring and Forecasting
- Optimal Experimental Design Methods
- Pneumonia and Respiratory Infections
- COVID-19 impact on air quality
- T-cell and B-cell Immunology
- Statistical Methods in Clinical Trials
- Respiratory viral infections research
- Software Reliability and Analysis Research
- Advanced Causal Inference Techniques
- Remote Sensing and LiDAR Applications
- Cardiovascular Disease and Adiposity
- NF-κB Signaling Pathways
- Toxoplasma gondii Research Studies
- Gene expression and cancer classification
- Biosimilars and Bioanalytical Methods
- Oral microbiology and periodontitis research
- Bacterial biofilms and quorum sensing
- Neonatal Respiratory Health Research
- Forest Ecology and Biodiversity Studies
- Histone Deacetylase Inhibitors Research
- Endoplasmic Reticulum Stress and Disease
- Software Engineering Research
- Immunotherapy and Immune Responses
Jilin University
2023
Soochow University
2021-2022
Children's Hospital of Suzhou University
2022
Harbin Institute of Technology
2021
Jiangxi Province Forestry Survey Planning Institute
2019
University of Michigan
2012-2017
Peking Union Medical College Hospital
2014-2015
Environment and Climate Change Canada
2014-2015
Tsinghua University
2014-2015
University of Maryland, Baltimore
2014-2015
Mounting evidence supports that fine particulate matter adversely affects cardiometabolic diseases particularly in susceptible individuals; however, health effects induced by the extreme concentrations within megacities Asia are not well described. We enrolled 65 nonsmoking adults with metabolic syndrome and insulin resistance Beijing metropolitan area into a panel study of 4 repeated visits across seasons since 2012. Daily ambient personal black carbon levels ranged from 9.0 to 552.5 µg/m 3...
As public awareness of consequences environmental exposures has grown, estimating the adverse health effects due to simultaneous exposure multiple pollutants is an important topic explore. The challenges evaluating impacts factors in a multipollutant model include, but are not limited to: identification most critical components pollutant mixture, examination potential interaction effects, and attribution individual presence multicollinearity. In this paper, we reviewed five methods available...
Few prospective studies have assessed the blood pressure effect of extremely high air pollution encountered in Asia's megacities. The objective this study was to evaluate association between combustion-related with ambulatory and autonomic function. During February July 2012, personal black carbon determined for 5 consecutive days using microaethalometers patients metabolic syndrome Beijing, China. Simultaneous ambient fine particulate matter concentration obtained from Beijing Municipal...
Inflammation and oxidative stress play critical roles in the pathogenesis of inhaled air pollutant-mediated metabolic disease. adipose tissues niches are widely believed to exert important effects on organ dysfunction. Recent data from both human animal models suggest a role for inflammation epicardial tissue (EAT) as risk factor development cardiovascular We hypothesized that inhalational exposure concentrated ambient fine particulates (CAPs) ozone (O3) exaggerates EAT perirenal (PAT)....
Streptococcus gordonii and oralis are among the first bacterial species to colonize clean tooth surfaces. Both produce autoinducer-2 (AI-2): a family of inter-convertible cell-cell signal molecules synthesized by LuxS enzyme. The overall aim this work was determine whether AI-2 alters interspecies interactions between S. DL1 34 within dual-species biofilms in flowing human saliva. Based upon bioluminescence assays, produced more activity than batch culture, both were able remove from...
Abstract Background Recently, many cases of pneumonia in children with Mycoplasma pneumoniae infection have been shown to varying degrees intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment patients are analyzed this study. risk factors for M. (MPP) formation explored, a factor scoring system is established. Methods MPP treated bronchoscopy were retrospectively enrolled the study from February 2015 December 2019. divided into group...
Joint effects of genetic and environmental factors have been increasingly recognized in the development many complex human diseases. Despite popularity case-control case-only designs, longitudinal cohort studies that can capture time-varying outcome exposure information long recommended for gene-environment (G × E) interactions. To date, literature on sampling designs G E interaction is quite limited. We therefore consider prioritize a subsample existing retrospective genotyping basis...
Background: Given the limited efficacy observed with single agents, there is growing interest in Phase I clinical trial designs that allow for identification of maximum tolerated combination two agents. Purpose: Existing parametric may suffer from over- or under-parameterization. Thus, we have designed a nonparametric approach can be easily understood and implemented trials. Methods: We propose two-stage adaptive biased coin design extends existing methods single-agent trials to dual-agent...
It was demonstrated that membrane-associated RING-CH 1 (March 1) might play an important role in the pathogenesis of asthma.The levels mRNA and protein were measured by qRT-PCR Western blot, respectively. Immunofluorescence assay used to determine whether March1 co-locates with HDAC11. Co-immunoprecipitation performed examine combination proteins. Moreover, luciferase measure promoter activity genes.The both OX40 ligand (OX40L) increased dendritic cells (DCs) from asthmatic children animals....
Abstract Objectives: This study aimed to analyze the clinical features of children with lobar pneumonia caused by Mycoplasma pneumoniae (MP) infection, provide a prognostic evaluation interventional bronchoscopy, and explore independent risk factors for bronchoscopic intervention in MP infection. We also construct an early-warning model intervention, so as objective tool clinicians. Methods: collected data from 533 The patients were divided into three groups according indications...
The software reliability growth model SRGM is an effective tool for evaluating in the testing phase. based on non-homogeneous Poisson process NHPP most widely used model. So far, validity range of has not been known. This article first reviews construction classic G-O model, summarizes modeling SRGM, and briefly analyzes research content classification SRGM. In order to verify fitting prediction performance many NHPP-type SRGMs actual test environment, this paper uses 26 conduct experiments...