A5101601826- Atherosclerosis and Cardiovascular Diseases
- Spinal Cord Injury Research
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Bioactive Natural Diterpenoids Research
- Hematopoietic Stem Cell Transplantation
- Cardiovascular Disease and Adiposity
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Pregnancy-related medical research
- Multiple Myeloma Research and Treatments
- Liver Disease and Transplantation
- Antifungal resistance and susceptibility
- Periodontal Regeneration and Treatments
- Spinal Hematomas and Complications
- Biomarkers in Disease Mechanisms
- Chemokine receptors and signaling
- Innovations in Medical Education
- Kruppel-like factors research
- Hippo pathway signaling and YAP/TAZ
- Apelin-related biomedical research
- Organ Transplantation Techniques and Outcomes
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
South China University of Technology
2024
Soochow University
2016-2023
First Affiliated Hospital of Soochow University
2016-2023
University of Liverpool
2023
University of Science and Technology of China
2021
United States Army Institute of Surgical Research
2019
Cleveland Clinic
2017
Abstract Rituximab efficacy in cancer therapy depends part on induction of complement-dependent cytotoxicity (CDC). Human CD59 (hCD59) is a key complement regulatory protein that restricts the formation membrane attack complex, thereby inhibiting CDC. hCD59 highly expressed B-cell non–Hodgkin's lymphoma (NHL), and upregulation an important determinant sensitivity NHL cells to rituximab treatment. Here, we report potent inhibitor rILYd4 enhances CDC vitro vivo, sensitizing rituximab-resistant...
Spinal cord injury is a grave neurological disability resulting in neuron degeneration and permanent paralysis. The inflammation triggered by the would promote spinal lesion turn. Activated astrocytes during inflammatory response could glial scar formation contribute to progression of injury. Interleukin 17 (IL-17) was upregulated responses contusion or compression cord. this study, IL-17 induce reactive which indicated well-known hallmark fibrillary acidic protein (GFAP) vitro vivo....
Accumulating evidence suggests a role of semaphorins in vascular homeostasis. Here, we investigate the Sema7A (semaphorin 7A) atherosclerosis and its underlying mechanism.Using genetically engineered Sema7A-/-ApoE-/- mice, showed that deletion attenuates atherosclerotic plaque formation primarily aorta ApoE-/- mice on high-fat diet. A higher level atheroprone lesser curvature correlation with disturbed flow. This notion is supported by elevated expression human umbilical venous endothelial...
Abstract Following spinal cord injury (SCI), immune cell infiltration creates an inflammatory and oxidative microenvironment (known as the secondary injury), which causes neuron death damage, dramatically hinders neurological functional recovery. Strategies that inhibit and/or function of neutrophils offer promises for SCI treatment because they can reduce injury; however, such strategies remain largely unexplored. Herein, a strategy using neutrophil membrane‐coated nanoparticles (NPs)...
Abstract Aims Chemoattractants and their cognate receptors are essential for leucocyte recruitment during atherogenesis, atherosclerotic plaques preferentially occur at predilection sites of the arterial wall with disturbed flow (d-flow). In profiling endothelial expression atypical chemoattractant (ACKRs), we found that Ackr5 (CCRL2) was up-regulated in an subpopulation by stimulation. We therefore investigated role CCRL2 its ligand chemerin atherosclerosis underlying mechanism. Methods...
Shikonin, a compound extracted from Zicao, has been demonstrated to hold anti-bacterial, anti-inflammatory, and anti-tumor activities in various diseases it shown protect human organs injuries. However, the effect of shikonin on recovery spinal cord injury (SCI) remains unknown. This study was designed estimate potential therapeutic underlying mechanism SCI vivo.In study, we used HE staining, ELISA assay, transfection TUNEL real time PCR Western blot detect effects rats.we showed that could...
Excessive neovascularization of atherosclerotic lesions increases plaque vulnerability and the susceptibility to rupture. Semaphorin 7A (Sema7A), a semaphorin family member, was recently reported promote formation by mediating d-flow-induced endothelial phenotypic change leukocyte adhesion. To extend our understanding proatherogenic role Sema7A, we investigated Sema7A in angiogenesis neovascularization. overexpression human umbilical vein cells (HUVECs) significantly upregulated VEGFA/VEGFR2...
Abstract HNG, a highly potent mutant of the anti‐Alzheimer peptide‐humanin, has been shown to protect against ischaemia‐reperfusion (I/R) injury. However, underlying mechanism related platelet activation remains unknown. We proposed that HNG an effect on function and thrombus formation. In this study, aggregation, granule secretion, clot retraction, integrin adhesion under flow conditions were evaluated. mice receiving or saline, cremaster arterial formation induced by laser injury, tail...
To prepare interleukin-1β-targeted nanoantibodies and observe their effects on apoptosis in hypoxic cardiomyocyte of mice.
Rationale: Platelets play an essential role in atherosclerosis, but the underlying mechanisms remain to be addressed. This study is investigate of platelets d-flow induced vascular inflammation and mechanism. Methods: We established a disturbed blood flow (d-flow) model by partial carotid ligation (PCL) surgery using atherosclerosis-susceptible mice wild-type observe platelet accumulation subendothelium or plaque immunostaining transmission electron microscopy. The mechanism subendothelial...
Blood plasma-based products have been recently utilized in different tissue engineering applications, ranging from soft repair to bone regeneration. Plasma contains fibrinogen which can be converted an insoluble fibrin-laden gel the presence of activated thrombin. In engineering, these materials serve either as a three-dimensional scaffold deliver therapeutic cells vivo or growth factor-rich supply for Unfortunately, are often mechanically weak and easily deformed, thus limiting their...
Abstract The reference nutrient intake for vitamin D in people aged ≥ 4 years is 10 μg/day the UK, which contrasts with recommended daily allowance of 15 1-70 USA. Using modelling published data, we compared 95% confidence intervals serum concentrations 25-hydroxyvitamin 3 (25(OH)D ) attained response to these two doses. 97.5% those taking vs. were predicted attain circulating 25(OH)D >44 nmol/L 50 nmol/L, respectively.
Objective To examine the efficacy of applying clinical pathway (CP) teaching model in orthopedics teaching.Methods Totally 64 medical undergraduates were randomized into 2 groups.The traditional method and CP separately preformed on them.Their scores theoretical,manipulation case analysis exams at end internship compared.Meanwhile questionnaire satisfaction degree also was conducted.Results Scores better group than classical (P ＜ 0.05).Conclusions The novel can promote standardization...
Background: Inhibition of plaque progression by various anti-atherosclerotic drugs is a canonical aspect underlying their therapeutic efficacy. Although existed animal models regression are available for drug evaluation, they either highly invasive or time-consuming. We therefore aimed to establish practical method study the mechanism atherosclerosis based on hemodynamic regulation atherosclerosis. Methods: A carotid model in mice was developed previously described model. Briefly, single...
Atherosclerosis preferentially develops at sites under disturbed blood flow (d-flow) that leads to steep multidirectional gradients of wall shear stress vascular predilection sites, promoting an oxidative, proapoptotic, and proinflammatory gene expression profile in endothelial cells. Sustained d-flow causes injury characterized by leukocyte infiltration, barrier dysfunction, eventually the formation atherosclerotic plaques. While previous studies suggest a role platelets via activation...