A5036426202- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Synthesis and properties of polymers
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Biopolymer Synthesis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- Carbohydrate Chemistry and Synthesis
- Surfactants and Colloidal Systems
- Protein purification and stability
- X-ray Diffraction in Crystallography
- Field-Flow Fractionation Techniques
- Hydrogels: synthesis, properties, applications
- nanoparticles nucleation surface interactions
- Crystallization and Solubility Studies
- Catalytic Cross-Coupling Reactions
- Conducting polymers and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Microwave-Assisted Synthesis and Applications
- Analytical Chemistry and Chromatography
- Nanofabrication and Lithography Techniques
- Microfluidic and Bio-sensing Technologies
Friedrich Schiller University Jena
2012-2018
IBM Research - Almaden
2015-2016
Cationic polymers play a crucial role within the field of gene delivery offering possibility to circumvent (biological) barriers in an elegant way. However, are accompanied either by high cytotoxicity or low efficiency. In this study, series molar mass poly(2-oxazoline)-based copolymers was synthesized introducing 2-ethyl-2-oxazoline, ethylene imine, and primary amine bearing monomer units representing new generation poly(ethylene imine) (PEI). The potential these modified PEIs as non-viral...
We describe the synthesis of matrix supported hydrogel structures based on amine containing poly(2-oxazoline)s and their use to bind release genetic material for potential applications in diagnostics or pathogen detection. Amine were synthesized by copolymerization 2-ethyl-2-oxazoline with a monomer bearing tert-butyl oxycarbonyl (Boc) protected group 2-position subsequent deprotection. The statistical copolymers used generate hydrogels cross-linking certain fraction groups epichlorhydrin....
A series of copolymers containing both amine groups linear poly(ethylene imine) (LPEI) and double bonds poly(2-(3-butenyl)-2-oxazoline) (PButEnOx) was prepared. To this end, a poly(2-ethyl-2-oxazoline) (PEtOx) precursor hydrolyzed to the respective LPEI functionalized in an amidation reaction with butenyl resulting bond poly(2-(3-butenyl-2-oxazoline)-co-ethylene (P(ButEnOx-co-EI)). Hydrogels were obtained by cross-linking dithiols under UV-irradiation networks different properties dependence...
Abstract A benzoin‐derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the unit performed enable defined encapsulation diverse organic compounds in polymeric structures allow for a well‐controllable polymer cleavage process. Selective tracking release kinetics encapsulated model from nano‐ microparticle containers by confocal laser scanning microscopy...
The synthesis of poly(2-oxazoline)-based block copolymers consisting a cationic and hydrophilic segment is described. self-assembly these macromolecules in organic solvents results the formation micelles vesicles, respectively, depending on solvent used. To transfer systems into water, cross-linking using glutaraldehyde was applied, followed by consumption excessive aldehyde functions either diethylamine or 6-aminofluorescein (6AF). cross-linked assemblies were analyzed regarding their size...
(Bio)degradable poly(ethylene imine-co-glycine)s (P(EI-co-Gly)) were synthesized through efficient and controlled oxidation of linear imine) (LPEI) using hydrogen peroxide in a methanol/water mixture. Temperature, concentration, reaction time varied to adjust the degree (DO). At low temperatures, process was found be well-controlled with almost 85% ethylene imine units converted corresponding amide. Importantly, more than 10% LPEI rendered polymers water-soluble. The molecular structure...
The large volume and diversified nanomedicine market, undergoing a rapid growth, relies not only on the creation applicative exploration of nanocarrier-based medicines showing significant potential, but in particular, demands quantitative assessment their physicochemical properties. In this study, we demonstrate situ multifunctional biodegradable nanoparticle (NP) entries as core components nanoscale drug delivery systems (NDDSs) by making use analytical ultracentrifugation (AUC). We...
Fast and easy purification amplification of DNA are prerequisites for the development point‐of‐care diagnostics. For this reason covalent coatings amine containing poly(2‐oxazoline)s (POx) on glass poly(propylene) surfaces prepared, to reversibly bind genetic material directly from biological samples. The polymer is deposited in a layer‐by‐layer process, whereas initial immobilization macromolecules surface accomplished by use an epoxy functionalized siloxane monolayer. Alternating treatment...
The high affinity of GLUT5 transporter for d ‐fructose in breast cancer cells has been discussed intensely. In this contribution, molar mass linear poly(ethylene imine) (LPEI) is functionalized with moieties to combine the selectivity delivery potential PEI genetic material. four‐step synthesis a thiol‐group bearing enables decoration cationic polymer backbone via thiol‐ene photoaddition. functionalization LPEI confirmed by 2D NMR techniques, elemental analysis, and size exclusion...
PEI was chemically-modified with carbohydrates and carbohydrate-mimetics to improve biocompatibility.
Deciphering the behavior of degradable nanoparticles in biological fluids is demonstrated by interference-free assessment. The resultant vastly different erosion characteristics provide a necessary stepping stone for their design toward translation.
ABSTRACT Despite an increasing effort to design well‐defined glycopolymers, the convenient synthesis of polymers with higher DPs (>100) and without tedious protection deprotection steps remains a challenge. Combining reversible addition fragmentation transfer (RAFT) polymerization efficient substitution primary bromo groups by thiols, we were able synthesize set glycopolymers up 115. With highly reactive monomer (2‐bromoethyl)‐acrylate low dispersities obtained that could efficiently be...
Abstract Ein Diol‐Linker mit Benzoin‐Grundkörper wurde synthetisiert und zur Herstellung biokompatibler Polyester verwendet, die bei Bedarf durch UV‐Licht vollständig abgebaut werden können. Um eine definierte Einkapselung von strukturell unterschiedlichen organischen Verbindungen in den hergestellten polymeren Materialien einen gut kontrollierbaren Polymerabbauprozess zu ermöglichen, umfassende strukturelle Optimierung der Monomerlinkereinheit durchgeführt. Die Verfolgung...