A5086714272- Advanced Polymer Synthesis and Characterization
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Nanoparticle-Based Drug Delivery
- biodegradable polymer synthesis and properties
- Click Chemistry and Applications
- Polymer Surface Interaction Studies
- Carbohydrate Chemistry and Synthesis
- RNA Interference and Gene Delivery
- Photopolymerization techniques and applications
- Glycosylation and Glycoproteins Research
- Biopolymer Synthesis and Applications
- Photochromic and Fluorescence Chemistry
- Hydrogels: synthesis, properties, applications
- DNA and Nucleic Acid Chemistry
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Crystallography and molecular interactions
- Nonlinear Optical Materials Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Supramolecular Self-Assembly in Materials
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Synthesis and properties of polymers
Friedrich Schiller University Jena
2015-2024
Dutch Polymer Institute
2008-2015
Institute of Macromolecular Chemistry
2014
Nara Institute of Science and Technology
2012
Kyoto University
2009
Eindhoven University of Technology
2009
Carl Zeiss (Germany)
2006
Glycopolymers consisting of styrene (St) and pentafluorostyrene (PFS) were synthesized by a combination nitroxide-mediated polymerization "click" chemistry. A series well-defined homopolymers as well block random copolymers St PFS obtained with different ratios using Bloc Builder an alkoxyamine initiator. Some showed self-assembly behavior into regular nanospheres diameters ranging from 70 to 720 nm applying the nanoprecipitation technique. In addition, thiol−glycoside...
The present paper describes matrix-free laser desorption/ionisation mass spectrometric imaging (LDI-MSI) of highly localized UV-absorbing secondary metabolites in plant tissues at single-cell resolution. scope and limitations the method are discussed with regard to plants genus Hypericum. Naphthodianthrones such as hypericin pseudohypericin traceable dark glands on Hypericum leaves, placenta, stamens styli; biflavonoids also pollen this important phytomedical plant. highest spatial...
A simple sodium chloride (NaCl) based (68)Ga eluate concentration and labeling method that enables rapid, high-efficiency of DOTA conjugated peptides in high radiochemical purity is described. The utilizes relatively few reagents comprises minimal procedural steps. It particularly well-suited for routine automated synthesis clinical radiopharmaceuticals. For the generator step, commercially available cation-exchange cartridges generators were used. was collected by use a strong cation...
Copper(II) complexes of tridentate dianionic β-ketoenaminic ligands derived from differently functionalized amino-deoxyglucoses were synthesized and characterized with respect to their structural, spectroscopic, catalytic properties. The (probably dimeric) complex {1,2-O-isopropylidene-6-N-(3-acetyl-2-oxobut-3-enyl)amino-6-deoxyglucofuranoso}copper(II) Cu(3 a) was a highly efficient catalyst for the catechol-oxidase-like oxidation 3,5-di-tert-butylcatechol (dtbc) into...
The antifouling properties against the simultaneous attack of five different bacteria and stability surface tethered poly(2-ethyl-2-oxazoline)s were investigated.
Overexpression of GLUT5 in breast cancer cell lines leads to extensive uptake fructose bearing nanoparticles.
Metal complexes possess unique tunable properties, such as radioactivity, cytotoxicity or photophysical features, enabling them to act diagnostic tracers therapeutic agents. In applying in biological systems, it is often necessary enhance their solubility and biocompatibility. To achieve goals, like the targeting of binding domains, transport systems enzyme activities, attachment carbohydrate moieties appears be suitable. Sugar-substitution periphery metal has therefore become a strongly...
Abstract The aims of the current study were to synthesize new responsive polymeric microgels with embedded silver nanoparticles and then employ these particles as catalyst for reduction reactions. To ends, stimuli‐responsive from PNIPAAm chitosan derivative firstly synthesized by free radical precipitation polymerization. Then, inside microgel networks in situ AgNO 3 . These temperature/pH sensitive a phase transition temperature 32–35 °C water at pH = 8, respectively. catalytic activity Ag...
A series of thermo-responsive glyco-poly(2-oxazoline)s based on 2-ethyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline were prepared. To study the effect sugar content solution behavior in water, two sets copolymers with constant monomer-to-initiator ratios 20 50 varying amounts hydrophobic alkene functionalized monomer synthesized. The glycopolymers obtained by photoaddition 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glycopyranose onto double bonds followed deacetylation saccharide residues....
Abstract Efficient delivery of short interfering RNAs reflects a prerequisite for the development RNA interference therapeutics. Here, we describe highly specific nanoparticles, based on near infrared fluorescent polymethine dye-derived targeting moieties coupled to biodegradable polymers. The dye, even when nanoparticle, mimics ligand hepatic parenchymal uptake transporters resulting in hepatobiliary clearance approximately 95% dye within 45 min. Body distribution, hepatocyte and excretion...
Abstract Only a small number of water‐soluble iron carbonyl type model compounds for the active centre in [Fe‐only] hydrogenase are known, and these models mainly prepared by substitution one CO ligands. In this publication we present new that contain peripherally bound sugar residue. Compounds were which 1,3‐disulfanyl‐2‐propyltetra‐ O ‐acetyl‐β‐ D ‐glucopyranoside unit is coordinated to core through either sulfur or selenium bridgehead atom. Electrochemical results both types reveal...
It is demonstrated that water-soluble, glucosylated poly(pentafluorostyrene) derivatives revealed favorable coating material properties for magnetic iron oxide nanoparticles. To prepare the in high reproducibility and purity as well sufficient amounts, a new route of synthesis established. The preparation characterization glucosylated, tetrafluorostyryl monomer, by thiol-para-fluorine "click" reaction, its polymerization, via nitroxide-mediated radical process, presented detail. In addition,...
A new 2-oxazoline monomer with a Boc-protected amino group in the side chain (BocOx) was synthesized. Homopolymerization as well copolymerization 2-ethyl-2-oxazoline (EtOx) revealed pseudo first order kinetic. series of homopolymers synthesized, deprotected and characterized regarding their structure thermal properties. The EtOx yielded water soluble polymers varying contents. After deprotection it shown by ethidium bromide assay that these were able to form complexes DNA. Treatment...
A new sugar-substituted 2-oxazoline monomer was prepared using the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. Its copolymerization with 2-ethyl-2-oxazoline as well 2-(dec-9-enyl)-2-oxazoline, yielding well-defined copolymers possibility to tune properties by thiol-ene "click" reactions, is described. Extensive solubility studies on corresponding glycocopolymers demonstrated that lower critical solution temperature behavior and pH-responsiveness of these can be adjusted in...