A5050980920- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Sleep and related disorders
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Genetic diversity and population structure
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Genetic and phenotypic traits in livestock
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Lung Cancer Research Studies
- Ion channel regulation and function
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Identification and Quantification in Food
Shanghai Ocean University
2022-2023
Civitan International
2023
University of Alabama at Birmingham
2023
Scripps (United States)
2020
Scripps Institution of Oceanography
2020
Scripps Research Institute
2018-2019
University of Wisconsin–Milwaukee
2012-2019
Army Medical University
2005-2006
Xinqiao Hospital
2005
Neuronal activity in medial prefrontal cortex (mPFC) is critical for the formation of trace fear memory, yet cellular mechanisms underlying these memories remain unclear. One possibility involves modulation intrinsic excitability within mPFC neurons that project to basolateral complex amygdala (BLA). The current study used a combination retrograde labeling and vitro whole-cell patch-clamp recordings examine effect conditioning on layer 5 mPFC–BLA projection adult rats. Trace significantly...
Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure chronic stress contributes the development of depression anxiety. However, molecular mechanisms underlying stress-responsive behaviors are not fully understood. Here, we identified orphan receptor GPR158 as regulator operating in prefrontal cortex (PFC) that links depression. is highly upregulated PFC human subjects with major depressive disorder. Exposure mice also increased protein...
Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management, but their addictive properties can lead severe abuse. We developed a whole-animal behavioral platform for unbiased discovery of genes influencing opioid responsiveness. Using forward genetics in Caenorhabditis elegans, we identified conserved orphan receptor, GPR139, with anti-opioid activity. GPR139 is coexpressed MOR opioid-sensitive brain circuits, binds MOR, and inhibits signaling heterotrimeric guanine...
Experience-dependent synaptic and intrinsic plasticity are thought to be important substrates for learning-related changes in behavior. The present study combined trace fear conditioning with both extracellular intracellular hippocampal recordings plasticity. Rats received one session of conditioning, followed by a brief conditioned stimulus (CS) test the next day. To relate behavioral performance measures CA1 physiology, brain slices were prepared within 1 h CS test. In trace-conditioned...
The β-amyloid (Aβ) deposition is one of the major pathological hallmark Alzheimer's disease. Dysfunction in autophagy has been reported to lead Aβ deposition. current study aimed investigate effects treadmill exercise on activity and demonstrate whether exercise-induced reduction was associated with changes activity. APP/PS1 transgenic mice were divided into sedentary (TG-SED, n=12) (TG-EXE, groups. Wild-type also (WT-SED, (WT-EXE, WT-EXE TG-EXE subjected for 12 weeks. levels plaques soluble...
Chronic administration of D-galactose simulates the changes in natural senescence and accelerates aging animal models has been used research. The present study was undertaken to investigate molecular mechanisms underlying effects exercise on learning memory rats with D-galactose-induced aging. performance rats, either after or without exercise, assessed Morris water maze test. effect treadmill expression amyloid-β 42 two key enzymes involved processing β-amyloid precursor protein, a...
Medial prefrontal cortex (mPFC) is critical for the expression of long-term conditioned fear. However, neural circuits involving fear memory acquisition and retrieval are still unclear. Two subregions within mPFC that have received a lot attention prelimbic (PL) infralimbic (IL) cortices (e.g., Santini E, Quirk GJ, Porter JT. J Neurosci 28: 4028–4036, 2008; Song C, Ehlers VL, Moyer JR Jr. 35: 13511–13524, 2015). Interestingly, PL IL may play distinct roles during but underlying mechanism...
Abstract Hypocretins are crucial for the regulation of wakefulness by excitatory actions on multiple subcortical arousal systems. To date, there is little information about direct postsynaptic effects hypocretins neurons in prefrontal cortex (PFC), which important higher cognitive functions and correlated with level wakefulness. In this study, we tested hypocretin‐1 acutely isolated PFC pyramidal rats studied possible ionic mechanisms using whole‐cell patch‐clamp techniques. Puff application...
The striatum plays a fundamental role in motor learning and reward-related behaviors that are synergistically shaped by populations of D1 dopamine receptor (D1R)- D2 (D2R)-expressing medium spiny neurons (MSNs). How various neurotransmitter inputs converging on common intracellular pathways parsed out to regulate distinct behavioral outcomes neuron-specific manner is poorly understood. Here, we reveal contributions D1R-MSNs D2R-MSNs towards reward delineated the multifaceted signaling...
Autism Spectrum Disorder (ASD) is a developmental disorder in which children display repetitive behavior, restricted range of interests, and atypical social interaction communication. CUL3, coding for Cullin family scaffold protein mediating assembly ubiquitin ligase complexes through BTB domain substrate-recruiting adaptors, has been identified as high-risk gene autism. Although complete knockout Cul3 results embryonic lethality, heterozygous mice have reduced CUL3 protein, demonstrate...
We have investigated the direct excitatory effects of hypocretin-1 on acutely isolated prefrontal cortical pyramidal neurons and explored signaling mechanisms these actions. Puff application caused an excitation in recorded neurons. These were abolished by a phospholipase C inhibitor D609, demonstrating that mediates actions hypocretin-1. A specific protein kinase inhibitor, bisindolylmaleimide II, blocked hypocretin-1, suggesting plays key role. Finally, applied intracellularly did not...
In the striatum, medium spiny neurons (MSNs) are heavily involved in controlling movement and reward. MSNs form two distinct populations expressing either dopamine receptor 1 (D1-MSN) or 2 (D2-MSN), which differ their projection targets neurochemical composition. The activity of both types is shaped by multiple neuromodulatory inputs processed GPCRs that fundamentally impact synaptic properties biasing behavioral outcomes. How these GPCR signaling cascades regulated what downstream they...
Opioids exert their analgesic effects by activating the μ‐opioid receptor (MOR), a G protein‐coupled expressed in nervous system. In addition to clinical pain relief, activation of MOR produces euphoria and leads dependence. Despite significant process understanding molecular mechanisms signaling, regulatory function are not fully understood. To better understand regulation uncover genes influencing we developed genetic behavioral platform utilizing nematode C. elegans. Mammalian was...
Abstract The Japanese anchovy, Engraulis japonicus , is an important economic fish that distributed in the northwest Pacific Ocean. effective assessment and management of fishery requires reliable information regarding its population’s genetic structure. recent development double digest restriction-site associated DNA sequencing (ddRAD-Seq) methods may contribute to discovery SNPs In our study, 98 single nucleotide polymorphism (SNP) markers were developed using ddRAD-Seq. observed...