The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.

We investigate the local structural heterogeneities that may appear in liquid water by studying a model of interacting pentamers. find energy minima which we identify with well-defined configurations, and advance hypothesis one these configurations be related to “high-density” occurring when subjected high pressure. Our results are consistent experimental data on effect pressure radial distribution function, further tested molecular dynamics simulations reported here.

Wavelength-dependent elastic-scattering spectra of highly scattering media measured with only a single fiber for both light delivery and collection are presented. White is used as source, oscillations the detected intensities seen function wavelength. The maximum minimum can be to determine scatterer size monodisperse distributions spheres when refractive indices known. In addition, several properties probe relevant tissue diagnosis examined discussed including effects absorption, broad...

Although H2O has been the topic of considerable research since beginning century, most its anomalous physical properties are still not well understood. First we discuss some anomalies this ''complex fluid. '' Then describe a qualitative interpretation in terms percolation concepts. Finally, recent experiments and simulations relating to liquid–liquid phase transition hypothesis that, addition known critical point water, there may exist ''second at low temperatures. In particular, very...

We have investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as an adjunctive tool for intraoperative rapid detection brain tumors and demarcation tumor from surrounding normal tissue. Measurements were performed on 29 excised specimens patients. There 21 instances low-grade eight high-grade tumors. Normal gray matter white tissue four epilepsy patients used a control group. One one misclassified Of low- tumors, 20 out 7 8 correctly classified by...

The reversible aggregation of red blood cells (RBC) is current basic science and clinical interest. Using a flow channel light transmittance (LT) through RBC suspensions, we have examined the effects wavelength (500 to 900 nm) on static dynamic aspects for normal suspensions with reduced or enhanced aggregation; oxygenation were also explored. Salient observations include: 1. significant parameters reflecting extent (i.e., number per aggregate); 2. no time course 3. prominent influence...

Potential application of elastic light single-scattering spectroscopy (ELSSS) for differentiating high-grade squamous intraepithelial lesions (HSIL) from non-HSIL tissues was investigated. An ELSSS system used to acquire spectra cervix tissues. A single-fiber optical probe with a diameter 100 μm both delivery and detection white the tissue. Spectroscopic measurements were acquired 95 ex vivo biopsy samples 60 pap smear positive patients normal tissue 10 after hysterectomy as negative control...

We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The is based on measurements backscattered and fluorescent light with steady-state fluorescence spectrometer. ratio scattered found be linearly proportional absorption coefficient photosensitizer. fiber-optic probe used for has small source-detector separation; therefore could performed through working channel an endoscope.

BACKGROUND Elastic light single-scattering spectroscopy (ELSSS) is a noninvasive and real-time technique that has been used to differentiate tumors from surrounding nontumor tissue in animal models humans. OBJECTIVE To investigate potential application of ELSSS as an adjunctive tool for noninvasive, vivo, differentiation malignant benign skin lesions detect positive surgical margins excised biopsy samples. METHODS In vivo spectroscopic measurements were performed on 28 23 patients. The...

Tissue oxygen saturation (StO2) is a useful parameter for medical applications. A spectroscopic method has been developed to detect pathologic tissues, due lack of normal blood circulation, by measuring StO2. In this study, human samples with different levels have prepared and spectra were acquired using an optical fiber probe investigate the correlation between spectra. linear ratio intensities (760 nm 790 nm) from found. validation saturations estimated measurements error 2.9%. It also...

A steady-state fluorescence technique was used to examine the annealing of films formed from high-T latex particles above glass transition temperature. The were prepared by sintering pyrene-labeled poly(methyl methacrylate) particles. During processes, transparency film changed considerably. Direct emission excited pyrene monitored as a function temperature detect these changes. Scanning electron microscopy in conjunction with Monte Carlo simulations photon diffusion interpret results....

Although H2O has been the topic of considerable research since beginning century, peculiar physical properties are still not well understood. We discuss recent experiments and simulations relating to hypothesis that, in addition known critical point water, there exists a “second” at low temperatures. In particular, we very measurements compression-induced melting decompression-induced lines high-pressure forms ice. show how knowledge these enables one obtain an approximation for Gibbs...

Although H2O has been the topic of considerable research since beginning century, its peculiar physical properties are still not well understood. We discuss recent experiments and simulations relating to hypothesis that, in addition known critical point water (below which two fluid phases — a lower-density gas higher-density liquid coexist), there exists “second” at low temperatures can coexist).

The Direct Fluorescence method was used to study the healing process during latex film formation above glass transition temperature. prepared from pyrene (P)-labeled poly(methyl methacrylate) (PMMA) particles. Heptane as a mixing agent. steady-state fluorescence technique employed measure density of polymer chains crossing particle–particle interface. Various films with different content were transparency below and Crossing found depend linearly on (time)1/2, which proposed by Prager...

As part of our ongoing efforts to understand the fundamental nature light scattering form cells and tissues, we present data on elastic from isolated mammalian tumor nuclei. The contribution internal structures in particular nuclei was compared whole cells. Roughly 55 percent at high- angles comes intracellular structures. An upper limit 40 fractional tissue determined. Using cell suspensions monolayer cultures different stages growth, have also found that greater than about 110 correlated...

Background: The aim of our study was to evaluate whether a portable, light-weight, light-emitting-diode phototherapy unit designed for home use is as effective conventional blue-light fluorescent (CFP) treating hyperbilirubinemia in neonates. Methods: A total 50 patients were recruited sequentially treatment using CFP (n = 25) and the home-type 25). Results: average rate decrease bilirubin levels 0.17 ± 0.02 0.20 0.01 mg/dL/hours at end 24 hours groups receiving by units, respectively. There...

Abstract The continuous‐wave back reflection diffuse optical tomography (rCWDOT) system is one of the new medical imaging modalities. This study examines success reconstruction and three‐dimensional (3D) image processing algorithms on data obtained from a heterogonous breast phantom by rCWDOT. Breast phantoms were prepared putting bit spleen inside tail. mimics tumor since it has more blood than tail fat. rCWDOT was used to acquire phantoms. reconstructed using transpose‐free quasi‐minimal...