A5100453700- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Circular RNAs in diseases
- Uterine Myomas and Treatments
- CAR-T cell therapy research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Radiomics and Machine Learning in Medical Imaging
- Sesquiterpenes and Asteraceae Studies
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Marine Sponges and Natural Products
- interferon and immune responses
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Traditional and Medicinal Uses of Annonaceae
- PI3K/AKT/mTOR signaling in cancer
Beijing Jishuitan Hospital
2025
Peking University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Xi'an Jiaotong University
2019-2024
China XD Group (China)
2019
Kyoto Pharmaceutical University
2007
In cervical cancer patients with intermediate-risk factors, the optimal adjuvant therapy is still controversial. We undertook a randomized trial (ClinicalTrials.gov Identifier: NCT01418859) to compare efficacy and toxicity of concurrent chemoradiotherapy topotecan cisplatin radiotherapy alone in patients. Eligible were randomly assigned one three treatment arms including arm A (radiotherapy only,RT), B(concurrent only, CCRT), C (concurrent following consolidation chemotherapy, CCRT + CT)....
Kallistatin has been recognized as an endogenous angiogenesis inhibitor and exerts pleiotropic effects in inhibiting tumor growth, migration, apoptosis, inflammation. The purpose of the present study was to investigate potential role mechanisms kallistatin cervical cancer. We demonstrated that effectively inhibited cell proliferation enhanced apoptosis a dose-dependent manner. Additionally, suppressed migration invasion activities markedly reduced expression matrix-degrading...
To assess the efficacy and safety of recombinant human adenovirus type 5 (H101) in patients with persistent, recurrent, or metastatic gynecologic malignancies.The study retrospectively enrolled persistent/recurrent/metastatic malignancies who received H101-containing treatment at The First Affiliated Hospital Xi'an Jiaotong University from September 1, 2019 to 30, 2021. H101 was injected intratumorally into target lesions dosage calculated based on tumor diameter once a day for five...
Abstract Background The posterior-inferior border of symphysis (PIBS) point system is a novel vaginal dose-reporting method and simple reliable proposed by the Medical University Vienna for both external-beam radiotherapy (EBRT) brachytherapy (BT). In this multicenter study, we sought to first evaluate radiation dose in Chinese cervical cancer patients according PIBS then analyze factors influencing distribution. Methods We collected data from medical records 936 who underwent concurrent...
Objective: Recent literature reports that radical hysterectomy followed by adjuvant radiotherapy has comparable progression-free survival and overall compared to for International Federation of Gynecology Obstetrics stage IIB cervical cancer. Now, we evaluate the cost-effectiveness (CE) these two treatment regimens. Primary secondary outcome measures: A decision-tree model was constructed comparing CE between arms using published studies rates treatment-related toxicity 5 years. The cost...
In this study, RNA-sequencing was used to investigate the differentially expressed miRNAs between cervical cancer tissues and matched adjacent non-tumor tissues. Five were sharply downregulated in tissue, including miR-199a, miR-22, miR-615, miR-3681-3p (miR-3681), miR-1193. Among them, miR-3681 uncharacterized. The results from qPCR analysis showed that expression decreased patients with compared control, human cell lines SiHa, HeLa, C4-1, C-33A Caski, normal epithelial line HCerEpic. Then,...
5536 Background: Previous small sample retrospective study has showed that H101 promising efficacy and favorable safety in patients with persistent /recurrent/metastatic (P/R/M) gynecological cancer. To further assess the effecacy of P/R/M cancer, we conducted this prospective Phase II explore tumor microenvironment (TME) through Cell DIVE multiplexed imaging solution. Methods: This was a prospective, open-label, single-arm (clinicaltrials.gov number NCT05051696). cancer who had at least one...
e15096 Background: Detection of circulating tumor DNA (ctDNA) or minimum residual disease (MRD) through somatic variant identifications in plasma samples has emerged as a promising approach for monitoring the clinical outcomes after surgical resections other therapies. However, due to very low ctDNA levels early-stage cancers and remissions therapies, volumes degradation caused qualities practice, sensitively identify mutations with allele frequencies those remains challenging technology...