A5103065389- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Primate Behavior and Ecology
- Renal and related cancers
- RNA Interference and Gene Delivery
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
- Bacteriophages and microbial interactions
- Blood transfusion and management
- Congenital heart defects research
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Erythrocyte Function and Pathophysiology
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Prion Diseases and Protein Misfolding
- Telomeres, Telomerase, and Senescence
Kanazawa University
2023-2024
Central Institute for Experimental Animals
2006-2024
University of Fukui
2024
Chiba University
2024
Hamamatsu University School of Medicine
2024
Osaka University
2024
Neocortex in the fetal brain Along path of human evolution, gene duplication and divergence produced a protein, ARHGAP11B, that is found humans but not nonhuman primates or other mammals. Heide et al. analyzed effects ARHGAP11B expression, under control its own human-specific promoter, marmoset (see Perspective by Dehay Kennedy). In early weeks growth, drove greater elaboration neural progenitors neocortex than evident normal marmoset. expression may be one cause more robust characterizes...
Although embryonic stem (ES) cell–like induced pluripotent (iPS) cells have potential therapeutic applications in humans, they are also useful for creating genetically modified human disease models nonhuman primates. In this study, we generated common marmoset iPS from fetal liver via the retrovirus‐mediated introduction of six transcription factors: Oct‐3/4, Sox2, Klf4, c‐Myc, Nanog, and Lin28. Four to five weeks after introduction, several colonies resembling ES were observed picked...
Nonhuman primate embryonic stem (ES) cells have vast promise for preclinical studies. Genetic modification in nonhuman ES is an essential technique maximizing the potential of these cells. The common marmoset (Callithrix jacchus), a primate, expected to be useful transgenic model However, genetic (cmES) has not yet been adequately developed. To establish efficient and stable modifications cmES cells, we inserted enhanced green fluorescent protein (EGFP) gene with heterotypic lox sites into...
Abstract Induced pluripotent stem (iPS) cells hold great promise for regenerative medicine and the treatment of various diseases. Before proceeding to clinical trials, it is important test efficacy safety iPS cell‐based treatments using experimental animals. The common marmoset a new world monkey widely used in biomedical studies. However, efficient methods that could generate from variety have not been established. Here, we report are efficiently reprogrammed into by combining RNA...
Pluripotent stem cells (PSCs), embryonic (ESCs), and induced PSCs (iPSCs) are excellent tools for studying development in organisms classified into naïve primed states. ESC-derived germline chimera individuals can be produced by injecting ESCs/iPSCs preimplantation embryos, conversion of human a state provides insights epiblast cell features. Non-human alternatives to ESCs/iPSCs, which elicit ethical issues. In this study, we used the common marmoset (Callithrix jacchus) as an animal model....
Alzheimer's disease (AD) is the leading cause of dementia which afflicts tens millions people worldwide. Despite many scientific progresses to dissect AD's molecular basis from studies on various mouse models, it has been suffered evolutionary species differences. Here, we report generation a non-human primate (NHP), common marmoset model ubiquitously expressing Amyloid-beta precursor protein (APP) transgenes with Swedish (KM670/671NL) and Indiana (V717F) mutations. The transgene integration...
Adverse early life experiences are well-established risk factors for neurological disorders later in life. However, the molecular mechanisms underlying impact of adverse on neurophysiological systems throughout remain incompletely understood. Previous studies suggest that social attachment to parents development indispensable infants grow into healthy adults. In situations where multiple offspring born a single birth common marmosets, human hand-rearing is employed ensure survival captivity....
In veterinary medicine, blood transfusion is commonly performed on companion animals. The common marmoset a small nonhuman primate with increasing popularity as an animal model in biomedical research. Because of its whole volume, the at high risk exsanguination, and required to care for life-threatening bleeding. However, few clinical evaluations exist transfusions marmosets. This study cross-matching nine marmosets surveyed therapeutic effects. Recipients included cases persistent bleeding,...
Abstract Early life experiences, such as parental loss, neglect, and child abuse, are well-established risk factors for neurological disorders later in life, including depression, anxiety disorders, post-traumatic stress disorder. However, the molecular mechanisms underlying impact of adverse childhood experiences on neurophysiological systems throughout remain incompletely understood. Common marmosets, which non-human primates, typically give birth to 2–4 offspring, but only two usually...