A5076665848- Prenatal Screening and Diagnostics
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Parvovirus B19 Infection Studies
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Fetal and Pediatric Neurological Disorders
- Congenital Anomalies and Fetal Surgery
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Endometrial and Cervical Cancer Treatments
- Neonatal Health and Biochemistry
- Gynecological conditions and treatments
- Chromatin Remodeling and Cancer
- Neurogenetic and Muscular Disorders Research
- Reproductive System and Pregnancy
- Hereditary Neurological Disorders
- Medical Coding and Health Information
- Ovarian function and disorders
- Neurofibromatosis and Schwannoma Cases
- Rabbits: Nutrition, Reproduction, Health
- Lymphadenopathy Diagnosis and Analysis
- Congenital limb and hand anomalies
National Iranian Oil Company (Iran)
2023
Shahid Beheshti University of Medical Sciences
2019
Tehran University of Medical Sciences
2015
Persistent infection with High Risk Human Papillomavirus (HR HPV) typesplaysamajor role in the development of cervical cancer. Therefore, detection HR HPV types is an essential part cancer screening. The aim this study was to estimate prevalence among healthy women undergoing routine screening Iran.In cross-sectional study,the results DNA typing 2453 normal Iranian womenwhowere referred for from September 2015 March 2017 were analyzed. Participants screened using COBAS assay and liquid based...
Human papillomavirus (HPV) is the most common viral sexually-transmitted infection. Despite HPV infection associated with several malignant disorders including penile and anal cancers, little known about epidemiology of in males, particularly developing countries.The aim this study was to determine prevalence its genotype distribution among Iranian males.Between March 2009 April 2014, a total number 483 referred Iran University Medical Sciences-affiliated sexually transmitted infections...
This study aimed to evaluate the maternal and umbilical cord blood antibody levels, after COVID vaccination during pregnancy.
Recent years have witnessed a shift from invasive methods of prenatal screening to non-invasive strategies. Accordingly, testing (NIPT) using cell-free fetal DNA in maternal plasma has gained considerable deal interest both geneticists and obstetricians. Efficacy this method identification common aneuploidies been extensively assessed singleton pregnancies. However, limited number studies addressed the twin In context, present study is aimed at efficacy NIPT pregnancies.NIPT was performed on...
Abstract The aim of present study was to assess the karyotypes amniotic fluid cells and find frequency chromosomal abnormalities their significance in clinical setting. A total 15,401 pregnant women were assessed from March 2016 May 2019, 14,968 samples successfully cultured. These fetuses grouped according different indications including advanced maternal age, abnormal nuchal translucency (NT) values, positive first/second trimester screening results, high risk NIPT very low PAPP-A free...
Nowadays, neonatal screening has become an essential part of routine newborn care in the world. This is a non-invasive evaluation that evaluated inborn errors metabolisms (IEMs) using tandem mass spectrometry (LC-MS/MS) for baby's risk certain metabolic disorders.This retrospective study was conducted on 39987 Iranian newborns who were referred to Nilou Medical Laboratory, Tehran, Iran, programs IEMs. We incorporated second-tier tests and secondary biomarkers improve positive predictive...
Multiples of the normal median (MoM) free βHCG is a valuable parameter in evaluation risk adverse pregnancy outcomes. In current retrospective study, we assessed maternal and fetal outcomes pregnant women having MoM levels < 0.2 or > 5 their first trimester screening (FTS). Relative trisomy 21 was significantly higher patients 5. On other hand, relative trisomies 13 18 Turner syndrome were those 0.2. Other chromosomal abnormalities nearly equally detected between hydrocephaly hydrops fetalis...
Distinct human papillomavirus (HPV) 18 variants are thought to differ in oncogenic potential and geographic distribution. As such, understanding the regional of HPV would be great importance for evolutionary, epidemiological, biological analysis. In this regard, sequence variations E6 gene were investigated characterize more common normal cells, premalignant, malignant samples collected from cervix. total, 99 analyzed by polymerase chain reaction sequencing. overall, lineages A was...
Human Papilloma Virus (HPV) genotypes concordance among sexual couples has been evaluated in many investigations with considerable variations the concordance. However, no such study carried out between Iranian yet.Urogenital specimen from both males and females of were taken transferred to Nilou laboratory for molecular analysis. HPV DNA extraction typing using cobas 4800 platform. Demographic virological data analyzed afterwards.One hundred fourteen enrolled study. The mean age participants...
Knowing the regional lineages/sublineages of human papillomavirus 31 (HPV 31) and 45 would be great importance for further evolutionary, epidemiological, biological analysis. In this regard, to characterize more common lineages sublineages HPV 45, sequence variations E6 gene were investigated in normal, premalignant, malignant samples collected from cervix Iran. total, 54 31- 24 45-positive analyzed by hemi-nested polymerase chain reaction (PCR) nested-PCR, respectively. All PCR products...
Objective: To study the value of α -fetoprotein (α -FP), β-human chorionic gonadotropin (β-HCG), inhibin A, and uncojugated estriol (UE3) at second trimester for early screening preeclampsia. Methods: This cohort was performed on 1 713 consecutive pregnant women with gestational age from 15 to 18 weeks. We measured serum levels -FP, β -HCG, UE3 they were followed-up 48 h after delivery. Results: A total recruited through 151 (8.8%) diagnosed preeclampsia (n=123, 21.5% in high risk, n=28,...
The advent of non-invasive prenatal testing (NIPT) in the screening fetal abnormalities has optimized care and decreased rate invasive diagnostic tests. In this retrospective descriptive study, we began with 1874 singleton pregnancies. After exclusion some cases, study cohort ended up 1674 cases. We analyzed performance NIPT based on results first trimester (FTS) using serum combined NT. cases were also compared to testing/pregnancy outcomes. Notably, subgroup FTS risk < 1000, was reported...
Abstract Background Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and hormonal disorder in women. This study aimed to assess the effect of maternal PCOS on screening aneuploidy first second-trimesters. Methods case-control was conducted Arash Hospital Nilou Laboratory 2017–2018. The test 90 healthy mothers. Finally, second-trimester compared between two groups using Chi-square, Mann-Whitney’s U students T tests regression model SPSS 21. P < 0.05 considered as...
OBJECTIVES: To evaluate the performance of current national screening policy for Down syndrome (DS) in Iran and suggest a more efficient protocol with wealth large series first-trimester (FTS) data obtained from Nilou medical laboratory. fulfill this aim, detection rate (DR), positive (PSR), false negative (FNR) odds being affected given results (OAPR) were calculated at different cutoff risk. In latest update DS program Iran, there is no place intermediate group to be further investigated....
Background & ObjectiveCervical cancer is the second most common and fourth leading cause of death in women. Among risk factors for cervical cancer, human papillomavirus (HPV) important one.Materials Methods In this cross-sectional retrospective study conducted from 2016 to 2020, 261 women with intra-epithelial neoplasia (CIN) grade two three referred one gynecological oncology clinics Shahid Beheshti University Medical Sciences, who were eligible enter evaluated by research unit relevant...
Relationship between Maternal Hemoglobin Concentration in the Second Trimester of Pregnancy and Neonatal Anthropometric Indices
Abstract Analysis of cell-free DNA in maternal blood has been proposed as a novel screening method for evaluation aneuploidies. The higher performance this technique trisomies compared to all currently available methods would lead widespread use clinical settings. In total, 1,066,829 singleton pregnancies referred Nilou Clinical Laboratory were screened chromosomal during period 12 years. First-trimester (FTS), Triple and Quad markers second-trimester (STS) well integrated results have...
BackgroundCervical cancer is one of the common cancers in developing countries, which has a high rate mortality. This study aimed to evaluate prevalence abnormal cervical cytology among Iranian women.MethodsIn this cross-sectional study, cytological results 137,484 women, who were screened for Tehran and 12 other provinces Iran from 2013 2016, investigated. The Pap smear was prepared by liquid-based method evaluated pathologist.ResultsThe overall studied population 3%. mean age 35.77 ± 9.6....