A5048058693- Phagocytosis and Immune Regulation
- Acute Myeloid Leukemia Research
- Pancreatitis Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Hematological disorders and diagnostics
- Palliative Care and End-of-Life Issues
- Single-cell and spatial transcriptomics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- CNS Lymphoma Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Patient Satisfaction in Healthcare
- Digital Imaging for Blood Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Viral Infections and Immunology Research
- Connective tissue disorders research
- Biomarkers in Disease Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
Assistance Publique – Hôpitaux de Paris
2007-2024
Université de Versailles Saint-Quentin-en-Yvelines
2009-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2024
Inserm
2006-2024
Université Paris-Saclay
2022-2024
Hôpital Ambroise-Paré
2009-2024
Hôpitaux Universitaires Paris-Ouest
2018-2021
Hôpital Avicenne
2018
CHU Ambroise Paré
2013
National Institutes of Health
2013
Background: Population trends in aging and improved cancer survival are likely to result increased prevalence the United States, but few estimates of burden illness among survivors currently available. The purpose this study was estimate a national, population-based sample. Methods: A total 1823 5469 age-, sex-, educational attainment–matched control subjects were identified from 2000 National Health Interview Survey. Multiple measures burden, including utility, summary measure health, days...
Growth-arrest-specific protein 6 (Gas6), an intracellular released by apoptotic cells, has been detected in normal plasma. As the Gas6 system implicated mouse susceptibility to sepsis, and as leukocyte apoptosis is thought play a major role physiopathology of human severe we studied plasma levels possibly related variables patients with sepsis.Matched case-control study.Adult intensive care unit university hospital.Thirty 30 organ failure not infection, healthy subjects matched for age...
Summary Vitamin K-dependent protein Gas6 (growth-arrest specific gene 6) plays a role in vascular smooth muscle cell (VSMC) survival and migration, as well endothelium leukocyte activation, could therefore be involved atherosclerosis. However, the study of mouse models has led to contradictory results regarding pro- or anti-atherogenic properties Gas6, relatively few data are available human pathophysiology. To better understand implication atherosclerosis, we studied expression secretion...
Abstract Background Myelodysplastic syndromes (MDS) are clonal hematopoietic diseases of the elderly characterized by chronic cytopenias, ineffective and dysplastic haematopoiesis, recurrent genetic abnormalities increased risk progression to acute myeloid leukemia. A challenge routine laboratory Complete Blood Counts (CBC) is correctly identify MDS patients while simultaneously avoiding excess smear reviews. To optimize review, latest generations hematology analyzers provide new cell...
Gas6 is a vitamin K-dependent antiapoptotic protein that has been implicated in cardiovascular pathophysiology. We report the development and validation of an ELISA for Gas6, variation plasma with hormonal status study designed to evaluate effect oral contraception on markers.After main stages assay, we measured concentrations 94 male 88 female healthy volunteers ages 18 38 years. Forty-five women then received contraceptive, which contained ethinylestradiol levonorgestrel, 3 months before...
According to WHO recommendations, diagnosis of chronic myelomonocytic leukemia (CMML) beforehand requires microscopic examination peripheral blood identify dysplasia and/or blasts when monocytes are greater or equal 1.0 × 109/L and 10% leucocytes. We analyzed parameters derived from SysmexTM XN analyzers improve the management for monocytosis. results complete count positioning dispersion polymorphonuclear neutrophils in 61 patients presenting with CMML 635 control a reactive used logistic...
Background: Heparin-induced thrombocytopenia (HIT) is a prothrombotic life-threatening disorder caused by an adverse reaction to heparin exposure. In this context, it imperative stop immediately and replace non-heparin anticoagulant therapy. Despite their advantages, the use of direct oral anticoagulants (DOACs) only emerging for HIT treatment, remains rare. Objective: To improve our knowledge on role DOACs as treatment give overview local practices in context. Patients/Methods: This...
Summary The diagnosis of Waldenström Macroglobulinaemia ( WM )/lymphoplasmacytic lymphoma LPL ) remains one exclusion because other B‐cell lymphoproliferative disorders (B‐ LPD ), such as marginal zone MZL can fulfil similar criteria, including MYD 88 L265P mutation. It has been suggested that expression the myeloid marker CD 13 (also termed ANPEP is more frequent in than B‐ and also described on normal malignant plasma cells. Here, was tested a cohort 1037 patients from 3 centres by flow...
Compelling evidence has emerged for the relevance of flow cytometry (FC) in diagnostic work-up myelodysplastic syndromes (MDS) but due to technical issues, erythroid lineage been under investigated, specifically therapeutic context.Using "no red cell lysis" method developed set up RED-score, we quantified fraction CD117/c-KIT-expressing precursors a cohort 144 MDS patients and studied correlation with response erythropoiesis-stimulating agents (ESA) sub 63 low-risk patients.We confirmed...
Prognosis of acute myeloid leukemia (AML) remains poor especially in older patients who are ineligible for standard chemotherapy or have refractory disease. Here, we study the potential Peroxisome Proliferator‐Activated Receptor (PPAR)‐γ agonist pioglitazone to improve treatment AML. We show that exerts an anti‐proliferative and anti‐clonogenic effect on AML cell lines KG‐1a, MOLM‐14 OCI‐AML3 primary cultures from patients. However, co‐culture cells with stromal mimicking bone marrow...
To compare cefoxitin and/or moxalactam 30 µg disc diffusion (DD) methods to detect methicillin resistance in coagulase-negative staphylococci (CoNS) using both high- and low-density (HD/LD) inoculum techniques. A challenge set of 192 CoNS was tested. DD test results were compared with PBP2a detection. With the LD inoculum, sensitivity/specificity 94.4%/100% 100%/92.4%, respectively, breakpoints Comité de l'Antibiogramme la Société Française Microbiologie. HD 93.7%/100% 100%/96.9%, CLSI a...
Abstract Introduction Monocytosis is a frequent trigger for blood smear review in routine hematology laboratory whereas chronic myelomonocytic leukemia (CMML) infrequent and arises mostly elderly patients. In order to define the best workflow monocytosis, we studied three diagnostic approaches: classical morphology approach (blood review), flow cytometry assay (quantification of monocyte subsets as described by Selimoglu‐Buet et al 2015), “mono‐dysplasia‐score” also referred “Monoscore (as...
L'hémophilie A acquise (HAA) est une pathologie hémorragique rare mais potentiellement sévère, causée par des auto-anticorps dirigés contre le facteur (F) VIII.En dehors cas idiopathiques, les principales étiologies sont auto-immunes, néoplasiques, médicamenteuses ou obstétricales.Notre observation porte sur un homme de 78 ans pris en charge aux urgences pour asthénie et hypotension après chute ayant entraîné volumineux hématome la cuisse.Ce patient a principaux antécédents médicaux myélome...