A5064025718- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Sepsis Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Blood properties and coagulation
- Diagnosis and treatment of tuberculosis
- Fungal Plant Pathogen Control
Centre Hospitalier Universitaire de Nantes
2017-2024
Animal, Santé, Territoires, Risques et Ecosystèmes
2023
Nantes Université
2015-2023
Centre d'Investigation Clinique de Nantes
2019
Pfizer (United States)
2019
Inserm
2015-2018
Institut Gustave Roussy
2016-2018
Délégation Paris 5
2015
Université Paris-Sud
2015
Université Paris Cité
2011-2015
Abstract Adeno-associated virus (AAV) gene therapies are highly promising, such as the onasemnogene abeparvovec (Zolgensma) in spinal muscle atrophy (SMA). We report first case of fatal systemic thrombotic microangiopathy (TMA) following a 6-month-old child with SMA type 1, carrying potential genetic predisposition complement factor I gene. Other cases TMA have recently been reported after and AAV9 minidystrophin therapy Duchenne muscular dystrophy. The risk-benefit ratio this must therefore...
Abstract Non-classical monocyte subsets may derive from classical differentiation and the proportion of each subset is tightly controlled. Deregulation this repartition observed in diverse human diseases, including chronic myelomonocytic leukemia (CMML) which non-classical numbers are significantly decreased relative to healthy controls. Here, we identify a down-regulation hsa-miR-150 through methylation lineage-specific promoter CMML monocytes. Mir150 knock-out mice demonstrate...
QuantiFERON-TB Gold In-Tube performance was evaluated in 19 French immunocompetent children (0.29-5.36 years; median: 1.52) with active tuberculosis. The rate of indeterminates results 0/19 and the rates positivity were 6/10 9/9 <2 2- to 5-year-old children, respectively. association tuberculin skin test could improve diagnosis tuberculosis even young children.
Although numerous recent publications have demonstrated interest in multiparameter flow cytometry the investigation of myelodysplastic disorders, it is perceived by many laboratory hematologists as difficult and expensive, requiring a high level expertise. We report multicentric open real-life study aimed at evaluating added value technically simple score described Ogata group for diagnosis syndromes. A total 652 patients were recruited prospectively four different centers: 346 syndromes, 53...
Summary The diagnosis of myelodysplastic syndromes ( MDS ) is often challenging, time‐ and resource‐consuming. A thorough analysis complete blood count CBC parameters could, however, help to screen for among other causes cytopenia. To test this hypothesis, 109 newly‐diagnosed patients 399 cytopenic older than 50 years with confirmed absence were enrolled in a prospective study. Multiparametric highlighted three that significantly different between the two cohorts: mean corpuscular volume,...
According to WHO recommendations, diagnosis of chronic myelomonocytic leukemia (CMML) beforehand requires microscopic examination peripheral blood identify dysplasia and/or blasts when monocytes are greater or equal 1.0 × 109/L and 10% leucocytes. We analyzed parameters derived from SysmexTM XN analyzers improve the management for monocytosis. results complete count positioning dispersion polymorphonuclear neutrophils in 61 patients presenting with CMML 635 control a reactive used logistic...
Germline mutations in runt-related transcription factor 1 (RUNX1), ETS variant 6 (ETV6) and ankyrin repeat domain 26 (ANKRD26) have been recognised as responsible of autosomal dominant inherited thrombocytopenia or platelet disorder, with an increased risk developing haematological malignancies (HM), mainly acute leukaemia (AL) myelodysplastic syndrome (MDS) (Duployez et al., 2016). Importantly, while all these disorders are associated abnormalities count functions, may be mild a bleeding...
Abstract The aim of this study was to assess the potential impact kinetics serum levels seven cytokines during induction in acute myeloid leukemia (AML) patients. Indeed, role cytokines, pathophysiology and response therapy AML patients, remains under investigation. Here, we report on peripheral two Fms‐like tyrosine kinase 3 ligand (FL) interleukin‐6 (IL‐6), evaluated first‐line intensive induction. A new risk stratification can be proposed, which supersedes ELN 2017 classification predict...
Abstract Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for first‐line intensive chemotherapy, were included with aim study influence on long‐term outcomes peripheral blood (PB) levels monocytic (M) (M‐MDSC) assessed by flow cytometry. A...
Next-generation sequencing (NGS) is used to investigate the presence of somatic mutations. The utility incorporating routine guide diagnosis and therapeutic decisions remains unclear. We report findings an observational, multicenter study that aimed assess impact mutation testing by NGS in a reallife setting chronic myeloid malignancies. A total 177 patients were enrolled, partitioned into two overlapping groups. In group (n=94), indication was search for clonal hematopoiesis, context...
Abstract In this monocentric prospective study, the influence on long‐term outcomes of peripheral blood levels monocytic‐myeloid‐derived suppressive cells (M‐MDSC) was investigated in 56 patients with acute leukemia (myeloid n = 47; lymphoid 9) before and after (Days+60/+90) allogeneic hematopoietic stem cell transplantation (Allo‐HSCT). A risk relapse found to be associated a level pregraft M‐MDSC above 1.4% by ROC curve analysis. multivariate analysis, threshold retained strong statistical...
Ovarian carcinoma is account for 4% of all women cancer deaths because late diagnosis at advanced stage. During chemotherapy, survey includes repeated assays antigen carbohydrate 125 (CA125), which a membrane glycoprotein belonging to the mucin family and secreted by 80% serous ovarian tumours. The aim this study was analyze clinical relevance follow-up CA125 kinetics five patients stages under neoadjuvant chemotherapy. assayed on Kryptor(®) (Thermo-Fisher BRAHMS) semi-logarithmic curve with...
Abstract Graft-versus host disease (GVHD) remains one of the main causes morbidity and mortality after allogeneic hematopoietic stem cell transplantation (ASCT). Prophylactic T depletion via antithymocyte globulin (ATG) during ASCT conditioning is standards care for GVHD prophylaxis, although optimal dosing strategy still unclear. Recent studies have reported that absolute lymphocyte count at time ATG administration could predict survivals in from unrelated donors. Here this issue was...
Abstract Tyrosine kinase inhibitor (TKI) therapies have profoundly changed the natural history of chronic myeloid leukemia (CML) and prolonged survival. However, in vitro vivo data suggest strongly that eradication most primitive CML stem cells will not be possible by use TKI alone. The mechanisms this inefficiency might involve cell autonomous (activation alternate signaling, reduced BCR-ABL expression) or non-cell (niche-related) pathways. It would therefore major interest to determine if...