A5053892976- Concrete and Cement Materials Research
- Innovative concrete reinforcement materials
- Innovations in Concrete and Construction Materials
- Aerogels and thermal insulation
- Cancer, Hypoxia, and Metabolism
- Magnesium Oxide Properties and Applications
- Concrete Properties and Behavior
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Building materials and conservation
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Grouting, Rheology, and Soil Mechanics
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Cancer-related gene regulation
- Smart Materials for Construction
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Recycled Aggregate Concrete Performance
- Protein Kinase Regulation and GTPase Signaling
- Life Cycle Costing Analysis
Translational Genomics Research Institute
2015-2024
National Institutes of Health
2024
National Cancer Institute
2024
Center for Cancer Research
2024
Beijing Institute of Technology
2017-2024
City of Hope
2021-2023
City Of Hope National Medical Center
2023
Shijiazhuang University
2021-2023
University of Nebraska Medical Center
2021
The University of Texas MD Anderson Cancer Center
2021
This study focuses on the development of low-cement eco-concretes incorporating recycled concrete aggregates (RCA) and waste materials such as wood ashes, aiming to achieve a balance between sustainability mechanical performance. Different mixes were designed with varying cement content (240–290 kg/m3) RCA replacement levels (25%–50% by weight). The used included II/A-LL 42.5 R cement, natural calcareous-silica aggregates, from C30/37 concrete, limestone filler. Experimental tests conducted...
ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC kinase family and has been shown to play role in cell migration, ECM synthesis, stress-fiber assembly, contraction. Increased ROCK expression reported multiple pathological conditions, including cancer. Here, we report increased 1 pancreatic tumor epithelial cells as well cancer associated fibroblasts (CAF). In our analysis, 62% samples exhibited ≥2+ staining intensity by IHC versus 40% adjacent normal...
Abstract The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, fibrotic, and hypovascular, marked by extensive desmoplasia maintained the cells, cancer-associated fibroblasts (CAFs) other stromal cells. There an urgent need to identify develop treatment strategies that not only target cells but can also modulate A growing number of studies implicate role regulatory DNA elements called super-enhancers (SE) maintaining cell-type-specific gene expression...
To understand the environmental impacts of carbon nanotubes (CNTs), toxicity study was carried out with water-soluble multi-walled (MWCNTs) using zebrafish ( Danio rerio ) as a model system. Zebrafish embryos were treated different concentrations MWCNTs. Teratogenic effects evaluated through changes in embryonic development after 24 hours post-fertilization (hpf), 48 hpf and 72 hpf. No observable effect concentration (NOEC) at 40 μ g/mL. Lowest (LOEC) MWCNTs which caused significant...
Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key factors facilitating induction of pro-desmoplastic pro-tumorigenic transcriptional programs fibroblasts. Mechanistically, HDAC-mediated changes chromatin architecture enable activation directed by serum response factor (SRF) forkhead box...