A5081900423- Glioma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Venous Thromboembolism Diagnosis and Management
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Blood groups and transfusion
- Diagnosis and treatment of tuberculosis
- Bone and Joint Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Urology and Nephrology Studies
- Hemoglobinopathies and Related Disorders
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
Salk Institute for Biological Studies
2023
Howard University Hospital
2020-2021
University of Pennsylvania
2006
North Central Cancer Treatment Group
2002
RTOG Foundation
2002
Eastern Cooperative Oncology Group
2002
Mayo Clinic in Arizona
2001
University of Chicago
1994
UConn Health
1989
PURPOSE: To compare survival and toxicity in adult patients treated with low-dose (50.4 Gy/28 fractions) versus high-dose (64.8 Gy/36 localized radiation therapy (RT) for supratentorial low-grade astrocytoma, oligodendroglioma, mixed oligoastrocytoma. PATIENTS AND METHODS: From 1986 to 1994, 203 eligible/analyzable were randomized: 101 RT, 102 RT. Almost half younger than 40 years, 95% had grade 2 tumors. Histologic subtype was astrocytoma (or oligo-astrocytoma dominant) 32% of...
Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key factors facilitating induction of pro-desmoplastic pro-tumorigenic transcriptional programs fibroblasts. Mechanistically, HDAC-mediated changes chromatin architecture enable activation directed by serum response factor (SRF) forkhead box...
A case of symptomatic Rathke's cleft cyst is described. In spite the intrasellar component and radiological clinical evidence involvement pituitary gland, sella turcica was minimally involved. MRI afforded optimal visualization localization intra- suprasellar components vis-à-vis optic chiasm, infundibular stalk, carotid arteries.
Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key factors facilitating induction of pro-desmoplastic pro-tumorigenic transcriptional programs fibroblasts. Mechanistically, HDAC-mediated changes chromatin architecture enable activation directed by serum response factor (SRF) forkhead box...
A preliminary multi‐institutional study has recently demonstrated that ratios of the hosphomonoesters, phosphoethanolamine plus phosphocholine, to NTP human non‐Hodgkin's lymphoma (NHL) easured by 31P MRS before initiation therapy can identify about 2/3 patients who will not exhibit a complete local clinical response. These should be encouraged undergo more aggressive alternative therapy, which entails some risk mortality but also offers hope response, remission or cure. However, limited...