A5083912400- Microscopic Colitis
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Digestive system and related health
- Probiotics and Fermented Foods
- Hepatitis Viruses Studies and Epidemiology
- Infant Health and Development
- Autoimmune Bullous Skin Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Antifungal resistance and susceptibility
- Intestinal and Peritoneal Adhesions
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Innovations in Medical Education
- Intestinal Malrotation and Obstruction Disorders
- Hospital Admissions and Outcomes
- Diabetes Management and Education
- Interprofessional Education and Collaboration
King Saud University
2015-2024
Queen's University Belfast
2024
King Khalid University Hospital
2012-2023
Prince Mohammed bin Abdulaziz Hospital
2023
King Saud Medical City
2016-2022
Dalhousie University
2017
King Khalid University
2014
Pediatric inflammatory bowel disease (IBD) is increasingly recognized in developing countries; however, the incidence and trend over time have not been reported. This retrospective study included children diagnosed with IBD gastroenterology centers Kingdom of Saudi Arabia between 2003 2012. The date birth, age at diagnosis, gender, final diagnosis were collected on special forms. Clinical, laboratory, imaging, endoscopy, histopathology results reviewed to confirm diagnosis. Descriptive...
Although increasing evidence suggests a role for fungi in inflammatory bowel disease [IBD], data are scarce and mostly from adults. Our aim was to define the characteristics of fungal microbiota newly diagnosed treatment-naïve children with Crohn's [CD].The referred colonoscopy were prospectively enrolled study at King Khalid University Hospital, Saud University, Al Mofarreh Polyclinics Riyadh. Tissue stool samples collected frozen till sequencing analysis. The confirmed CD diagnosis...
Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe pattern and risk factors delay IBD Saudi children.This a multicenter study retrospective/prospective design. Data on diagnostic children Crohn's (CD) ulcerative colitis (UC) were retrieved from physician's notes. Multivariate regression analysis used assess long diagnosis.There 240 183 CD UC, respectively. The median delays 8 5 months respectively, significantly longer than UC...
Viruses are common components of the intestinal microbiome, modulating host bacterial metabolism and interacting with immune system, a possible role in pathogenesis immune-mediated diseases such as celiac disease (CeD). The objective this study was to characterize virome profile children new-onset CeD. We used metagenomic analysis viral DNA mucosal fecal samples from CeD controls performed sequencing using Nextera XT library preparation kit. Abundance log2 fold changes were calculated...
Abstract Background: The role of microbiota in the pathogenesis ulcerative colitis (UC) has been increasingly recognized. However, most reports are from Western populations. In Middle Eastern countries, including Saudi Arabia, little is known about microbiota. Therefore, our aim was to describe bacterial profile and signature pediatric UC Arabia. Methods: Twenty children with 20 healthy controls enrolled study gave stool samples. rectal mucosal samples were taken non-UC controls. Inclusion...
Objectives: To characterize the clinical presentations and diagnosis including serological tests histopathological findings in children with celiac disease. Methods: All (less than 18 years) confirmed disease diagnosed over a 6 year period at private tertiary care health center Riyadh, Saudi Arabia were studied retrospectively. Information collected included demographics, presentation diagnostic modalities serology small intestinal histology reported by Marsh grading. Results: A total of 59...
Purpose: To describe the clinical characteristics of celiac disease (CD) among Saudi children and to determine adherence rate gluten free diet (GFD) its determinant factors them.Methods: A cross-sectional study was conducted, in which all families registered Celiac Patients Support Group were sent an online survey.Only with 18 years age younger biopsy-confirmed CD included. Results:The median 113 included 9.9 years, at symptom onset 5.5 diagnosis 7 time between presentation final 1...
Intestinal dysbiosis has been reported to be associated with celiac disease (CeD) in Western populations but little is known other who have different dietary lifestyle and genetic background. The purpose of this study was determine whether a microbiota profile CeD children Saudi Arabia.Forty CeD, 20 healthy controls, 19 non-CeD controls were enrolled. median age at diagnosis 10.3, 11.3 10.6 years fecal, mucosal control groups, respectively. Significant differences microbial composition...
Celiac disease (CeD) is a multisystem immune-mediated multifactorial condition strongly associated with the intestinal microbiota.To evaluate predictive power of gut microbiota in diagnosis CeD and to search for important taxa that may help distinguish patients from controls.Microbial DNA bacteria, viruses, fungi, was isolated mucosal fecal samples 40 children 39 controls. All were sequenced using HiSeq platform, data analyzed, abundance diversities assessed. For this analysis, evaluated by...
To investigate the accuracy of fungal dysbiosis
ABSTRACT Since the first description of celiac disease (CeD) by Samuel Gee in 1888 and later “miraculous discovery” that bread was responsible for this condition following World War II Europe, there has been an exponential growth knowledge regarding CeD. Just when we thought knew everything to know about it, is, however, offering new challenges, with its presentation having significantly morphed over years from cases overt gastrointestinal symptoms, malnutrition, atrophic villi on duodenal...
Rickets is commonly seen as a sign of malabsorption like celiac disease if it not treated appropriately with vitamin D and calcium supplements. The aim this study was to examine the frequency diagnosis among children unexplained rickets in Saudi at tertiary hospital setting.Retrospective review records patients referred over 10 years pediatric gastroenterology hepatology unit.The included all for evaluation osteomalacia screened disease. made on basis history, physical examination,...
Purpose: To determine the socio-economic impact of gluten free diet (GFD) on Saudi children and their families Methods: A cross-sectional study was conducted in which an online questionnaire sent to all registered celiac patients support group.We included only (age 18 years age younger) with biopsy-confirmed disease (CD).Results: total 113 were final analysis, median 9.9 years; 62.8% females.One hundred (88.5%) participating reported that GFD food not easily available areas, 17% them it at...
Objective To describe the characteristics of hepatitis E virus (HEV) infection in a cohort children from Upper Egypt using data large multicentre prospective study acute viral (AVH). Methods Data subjects aged 2–18 years with AVH or close contacts those found to have asymptomatic were included analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded analysed. Results A total 123 patients (73 boys, 50...
Five children with glucose-galactose malabsorption (GGM) are presented. Two infants from Saudi Arabia were first-degree relatives, the third infant was unrelated and other two of Yemeni Syrian origin, respectively. All had chronic diarrhoea four failed to thrive since early infancy. stools positive for reducing substances, sugar chromatography showed glucose galactose malabsorption. Small bowel biopsies normal in all. One developed gangrene both legs as a complication hypernatraemia...
The aim of the present study was to investigate relation between consanguinity and inflammatory bowel diseases (IBD).Review medical records children with a final diagnosis IBD determine age, sex, type IBD, supplemented by information on family history (FH) in relatives. There were 138 children, ages 1.4 19.3 years, 50% girls.The prevalence 50%, 53%, 39% 60% Crohn disease (CD), ulcerative colitis (UC), controls, respectively. significantly higher controls than patients UC (P = 0.02 0.026,...
Incidence and severity variations of inflammatory bowel disease (IBD) have been reported from Western populations between continents regions the same countries. However, no data were available other countries.To investigate regional differences in IBD profiles pediatric patients Kingdom Saudi Arabia.Data a national multicenter study used. The incidence, time trend, clinical presentation Crohn's (CD) ulcerative colitis (UC) Central region (CR), (WR), Eastern (ER) analyzed compared....
Celiac serology can be transiently elevated in patients with type 1 diabetes mellitus (T1DM) and normalized despite gluten consumption. This study aimed to identify the frequency predictive factors of spontaneous normalization anti-tissue transglutaminase (anti-TTG-IgA) antibodies these patients.The charts all (≤18 years) T1DM were retrospectively reviewed from 2012 2021 at a tertiary care center Riyadh, Saudi Arabia. The following data collected: clinical characteristics participants,...
Ulcerative colitis (UC) is an immune-mediated chronic inflammatory condition with a worldwide distribution. Although the etiology of this disease still unknown, understanding role microbiota becoming increasingly strong.